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Course Criteria
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3.00 Credits
1120 NEUROPHARMACOLOGY
COURSE LEADERS:
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5.00 Credits
1128 DEVELOPMENTAL NEUROSCIENCE
COURSE LEADERS: Drs. Mark Mehler and Zaven Kaprielian
CREDITS/CLASS MEETINGS: 5 semester hours/three 1.5 hour meetings per week for a total of approximately 37 classes.
PREREQUISITE BACKGROUND: Undergraduate courses in Developmental Biology, Molecular Genetics and Neuroscience are recommended but not required.
SUGGESTED BACKGOUND READING: Fundamental Neuroscience, Zigmond et al.,; Principles of Neuroscience, Kandel and Schwartz.
SUITABILITY FOR 1ST YEAR STUDENTS: Recommended for 1st year students.
COURSE DESCRIPTION: This course will cover the cellular and molecular principles underlying the construction of a functioning nervous system. The course will begin with overviews of neurogenesis, neural patterning and axon guidance, and an introduction to neuroembryology. Subsequent classes will focus on neural induction, patterning of the neuraxis, stem cell biology, growth factors/cytokines and relevant signaling mechanisms, neurogenesis and gliogenesis, forebrain development, neuronal cell death, axon guidance mechanisms, synapse assembly and neural circuit formation. Throughout the course, insights gained from both vertebrate and invertebrate model systems will be discussed.
Grading will be based on participation in course director-facilitated Student Synopsis and Discussion classes and Student Study Sections, as well as on a written Grant Proposal. There are eight Student Synopsis and Discussion classes interspersed with faculty lectures. During these classes, students are expected to summarize the main points of the preceding two or three lectures, as well as present and discuss key papers in these areas. Each student in the class will be required to write an original grant proposal on a topic in Developmental Neuroscience. There will be two Student Study Sections during the semester. At these study sections, students will critique their classmates' grant proposals. After each study section, students will have the opportunity to revise their grant proposal based on the recommendations of their peers. The final revision of the grant proposal will be turned in on the last day of class in lieu of a final exam and will be graded by the course directors.
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5.00 Credits
1129 MOLECULAR AND CELLULAR NEUROSCIENCE
COURSE LEADER: Dr. Kamran Khodakhah
CREDITS/CLASS MEETINGS: 5 semester hours in the form of three 2 hour meetings per week for a total of approximately 45 presentations. A number of lectures will be devoted to invited speakers from outside the Medical School, and presentations by the students.
SUGGESTED BACKGOUND READING: "Principles of Neuroscience" by Kandel and Schwartz and Jessell, and "From Neuron to Brain: A Cellular and Molecular Approach to the Function of the Nervous System"(4th Edition) by A. Robert Martin, Bruce G. Wallace, Paul A. Fuchs, John G. Nicholls
SUITABILITY FOR 1ST YEAR STUDENTS: This course is a pre-requisite for the Systems Neuroscience course. Therefore, students interested in Neuroscience are highly encouraged to take this (and ideally the Developmental Neuroscience course) in their first year.
COURSE DESCRIPTION: The course offers a multidisciplinary approach to the study of the nervous system from first principles. The class format consists of a combination of formal and informal lectures and student presentations with a major emphasis on interactive class discussion. This is a very demanding course. The course requires active student participation during the class and offers extensive review sessions if needed.
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0.00 - 4.00 Credits
1140 BIOINFORMATICS AND COMPUTATIONAL BIOLOGY OF PROTEINS
COURSE LEADER:
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2.00 Credits
1205 BIOCHEMISTRY OF NUCLEIC ACID-LIGAND INTERACTIONS
Course Leaders:
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5.00 Credits
1210 SYSTEMS NEUROSCIENCE
COURSE LEADERS:
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2.00 Credits
1214 TOPICS IN ADVANCED MAMMALIAN GENETICS
COURSE LEADERS: Drs. Bernice Morrow and Yousin Suh
CREDITS/CLASS MEETINGS: 3 semester hours; 2 sessions per week.
PREREQUISITE BACKGROUND: Students enrolled in this are required to have completed the AECOM Molecular Genetics course. Students wishing to enroll that have had the equivalent course elsewhere should see one of the instructors concerning the suitability of their backgrounds. It is not recommended for first year students with no prior genetics graduate training.
SUITABILITY FOR 1ST YEAR STUDENTS: Not recommended unless the first year student has had an equivalent prerequisite course in genetics (see above).
COURSE DESCRIPTION: In recent years, it has been clearly established that most of the diseases and disorders that affect the human population have a genetic basis. Defects in meiosis have a large impact on the development of the embryo or during infancy. Single gene mutations have their greatest impact during childhood, while complex disorders involving mutation or alterations in genes and environmental effects have their greatest impact as we age. Complex disorders include diabetes, obesity, heart disease and mental illness. Dissection of these disorders has been a major goal of the human genome effort because they affect most of us. We will discuss the basic principles of mammalian genetics and the modern tools for genetic analysis of simple and complex traits. The availability of the complete sequence of human and other genomes has revolutionized the process cloning of genes involved in these disorders. Much of the genome does not encode genes. The availability of the sequence will also enable us to understand the function of the genome at different levels, including important epigenetic mechanisms such as imprinting. We will discuss how model organisms can be used to understand the function and pathophysiology of disease genes. The course will be technology oriented but examples from specific disease entities will be used to illustrate the power of the technologies.
Course Format: The course will involve sessions that will be divided into a lecture and paper discussion. The most exciting papers that highlight the points of the lecture will be discussed. One student will be responsible for presenting the details of one paper. Another student will be responsible for eliciting a discussion from the group. The presentations will constitute 30% of the final grade. Every student is expected to participate actively (70% of final grade) in each session. There will be no final exam.
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2.00 Credits
1215 NEUROANATOMY: BASIC AND APPLIED
COURSE LEADER:
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2.00 Credits
1216 PROTEIN FOLDING: DISEASE TO DESIGN
Course Leaders:
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3.00 Credits
1218 DEVELOPMENTAL BIOLOGY
COURSE LEADER: Dr. Nick Baker
CREDITS/CLASS MEETINGS: 3 semester hours, approximately 25 class meetings, 1-1/2 hours each. This year's course will be organized around discussion of current and emerging topics in developmental biology. In addition to formal presentations, faculty will also facilitate presentations by small groups of students for some of the sessions. Evaluation will be based on presentations and class participation. There will be no examinations.
PREREQUISITE BACKGROUND: Most students will have taken Molecular Genetics and Gene Expression or equivalent courses. However, students (including first years) without this background can be considered on an individual basis, and should see the course leader for advice.
SUGGESTED BACKGROUND READING: Select from Alberts et al., Molecular Biology of the Cell, 4th edition 2002, Chapter 21; Hartwell et al., Genetics - from Genes to Genomes, 3rd edition 2008, Chapters 18 & 20; relevant chapters of "Developmental Biology", by Scott F. Gilbert, (Sinauer Associates, 5th edition 1997); relevant chapters of Squire et al "Fundamental Neuroscience", 2nd edition Academic Press 2002; The Art of Genes - how Organisms Make Themselves, by Enrico Coen, OUP 2000.
SUITABILITY FOR 1ST YEAR STUDENTS: Yes, with suitable undergraduate preparation, or if they have taken the courses equivalent to those described above.
COURSE DESCRIPTION: Developmental biology impacts nearly all areas of biology and medicine, representing the integration of classical embryology, modern molecular genetics, and systems biology. Discoveries in developmental biology contribute to mechanisms as diverse as signal transduction, cell proliferation, differentiation, and morphogenesis, and affect our perspective of fields ranging from evolution to cancer. In the future, developmental biology will continue to play an important role in understanding birth defects and pathogenic processes throughout life, and in understanding stem cells and regenerative medicine.
Topics in the Developmental Biology course are chosen by the participating faculty and are relevant to developmental problems that are being investigated at AECOM. They will include birth defects, cardiac defects and development, eye induction and development; stem cells, asymmetric cell divisions, and cellular polarity; neuronal development, axon pathfinding, and the maintenance of neuronal connections throughout life; morphogen signaling, developing signaling pathways and signal transduction, and developmental systems biology. The course material does not concentrate on any particular organism. Aspects of mouse and human development, Xenopus and zebrafish, C. elegans and Drosophila will be included, and conserved molecular and evolutionary aspects of development are expected to be common themes.
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