BIOS 1214 - Advanced Mammalian Genetic

Institution:

Yeshiva University

Subject:

Biomedical Sciences (Graduate)

Description:

1214 TOPICS IN ADVANCED MAMMALIAN GENETICS COURSE LEADERS: Drs. Bernice Morrow and Yousin Suh CREDITS/CLASS MEETINGS: 3 semester hours; 2 sessions per week. PREREQUISITE BACKGROUND: Students enrolled in this are required to have completed the AECOM Molecular Genetics course. Students wishing to enroll that have had the equivalent course elsewhere should see one of the instructors concerning the suitability of their backgrounds. It is not recommended for first year students with no prior genetics graduate training. SUITABILITY FOR 1ST YEAR STUDENTS: Not recommended unless the first year student has had an equivalent prerequisite course in genetics (see above). COURSE DESCRIPTION: In recent years, it has been clearly established that most of the diseases and disorders that affect the human population have a genetic basis. Defects in meiosis have a large impact on the development of the embryo or during infancy. Single gene mutations have their greatest impact during childhood, while complex disorders involving mutation or alterations in genes and environmental effects have their greatest impact as we age. Complex disorders include diabetes, obesity, heart disease and mental illness. Dissection of these disorders has been a major goal of the human genome effort because they affect most of us. We will discuss the basic principles of mammalian genetics and the modern tools for genetic analysis of simple and complex traits. The availability of the complete sequence of human and other genomes has revolutionized the process cloning of genes involved in these disorders. Much of the genome does not encode genes. The availability of the sequence will also enable us to understand the function of the genome at different levels, including important epigenetic mechanisms such as imprinting. We will discuss how model organisms can be used to understand the function and pathophysiology of disease genes. The course will be technology oriented but examples from specific disease entities will be used to illustrate the power of the technologies. Course Format: The course will involve sessions that will be divided into a lecture and paper discussion. The most exciting papers that highlight the points of the lecture will be discussed. One student will be responsible for presenting the details of one paper. Another student will be responsible for eliciting a discussion from the group. The presentations will constitute 30% of the final grade. Every student is expected to participate actively (70% of final grade) in each session. There will be no final exam.

Credits:

2.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.yu.edu

Phone Number:

(212) 960-5400

Regional Accreditation:

Middle States Association of Colleges and Schools

Calendar System:

Semester

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