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Course Criteria
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3.00 Credits
1032 QUANTITATIVE IMAGING OF CELLS
COURSE LEADERS: Drs. Ben Ovryn and Erik Snapp
CREDITS/CLASS MEETINGS: 3 semester hours; Lectures: 1.5 hrs, twice a week plus laboratories: 1.5 hrs, once per week.
RECOMMENDED BACKGROUND: Undergraduate courses in Biochemistry, Cell Biology, Physics, Algebra, Statistics, and Trigonometry.
COURSE TEXT: Fundamentals of Light Microscopy and Electronic Imaging by Douglas B. Murphy Methods in Cell Biology. Volume 81. Digital Microscopy: 3rd Edition Ed. by Greenfield Sluder and David E. Wolf. Course notes and additional materials to be assigned.
SUITABILITY FOR 1ST YEAR STUDENTS: All graduate and MSTP students may enroll.
ENROLLMENT: Enrollment for the course is limited to approximately 15 students due to restricted lab space. Preference will be given to 2nd year and above graduate and MSTP students with a quantitative imaging component to their projects.
NOTE: This is a closed registration and you must get approval from the course leaders in order to register for the course.
COURSE DESCRIPTION: This course presents an in-depth analysis of the principles and applications of light microscopy as applied to imaging cellular structures and molecules. Topics will include: the essentials of light microscopy; fluorophores; live cell imaging; deconvolution; confocal microscopy; photomanipulation; fluorescence correlation spectroscopy, multi-photon intravital imaging; evanescent wave imaging; fluorescence energy transfer and fluorescence lifetime imaging; FACS and evolving microscopies. Formal lectures will be supplemented with laboratory demonstrations that use state-of-the-art microscopes. Grading will be based upon a combination of laboratory exercises, problem sets, midterm, and a final exam.
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3.00 Credits
1105 CRITICAL READING FOR MOLECULAR BIOLOGISTS
COURSE LEADERS: Drs. Victoria Freedman and Moshe Sadofsky
CREDITS/CLASS MEETINGS: 3 semester hours. There will be two 1.5 hour sessions per week. Sessions will follow a Socratic Format in which students discuss a scientific paper under the guidance of faculty facilitators and course leaders. In the first session, one student will present an oral introduction to the pre-assigned paper and provide background and rationale to the investigation, including why the study was needed, and also explain potentially unfamiliar techniques. The second session also will have a student presenter and will be facilitated by expert faculty member(s). This session is meant for in-depth discussion with broad student participation and critical analysis. Part of the course will also be devoted to helping students develop Critical Listening skills by attending seminars together and then discussing these in class. Class attendance is mandatory. Failure to attend more than two sessions will result in a grade of Fail, or no credit. There will be an in-class final exam requiring the student to compose a title and abstract for a chosen paper, as well as criticizing the paper. The final grade will be based on class participation, oral and PowerPoint presentations, and the final written exam.
PREREQUISITE BACKGROUND: No prerequisites are required. To ensure verbal participation on the part of all students, enrollment will be limited to 15 students, on a first come/first served basis.
SUITABILITY FOR 1ST YEAR STUDENTS: This course is open to all students.
COURSE DESCRIPTION: One original paper will be dissected in great detail in each session, and students are required to participate in all the discussions and to give presentations on assigned dates. Papers will be chosen to illustrate important approaches to a broad range of problems in molecular biology, cell biology, biochemistry, genetics, immunology, etc. The course is designed to teach graduate students to read the original scientific literature at a depth that will permit them to form independent evaluations of the importance, degree of certitude, and accuracy of the studies. The course will also teach critical listening skills and critical analysis of seminars. In order to allow stimulating and thorough analysis of the papers and seminars, the course is limited to a group of 15 students.
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3.00 Credits
1106 HORMONE ACTION AND SIGNAL TRANSDUCTION
COURSE LEADERS:
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3.00 Credits
1107 MECHANISMS OF DISEASE
COURSE LEADER: Dr. Bridget Shafit-Zagardo
CREDITS/CLASS MEETINGS: 3 semester hours; Approximately 22 lectures will be given by prominent guest lecturers and AECOM faculty.
PREREQUISITE BACKGROUND: Knowledge of Immunology and Biochemistry is helpful.
SUITABILITY FOR 1ST YEAR STUDENTS: Yes.
COURSE DESCRIPTION: This multidisciplinary course will investigate the pathobiology of human diseases and relevant animal models. Topics will include cellular pathology and the mechanisms of cell injury and repair. The course will emphasize the immunologic, molecular, genetic, and biochemical mechanisms that result in the gross and microscopic changes taking place within affected tissues. Types of injury to be explored in depth will include: biochemical/genetic (Vera-delete diabetes and sickle cell anemia from within the paranthesis) (expansion of trinucleotide repeats, chromosomal abnormalities, cancer), inflammatory (Multiple Sclerosis, atherosclerosis), infectious (Acquired Immunodeficiency Syndrome and Tuberculosis), environmental (DNA damage). The pathobiology of aging, senescence and cell death will be examined in detail. Lectures will include Einstein faculty and prominent guest lecturers within the field. The course requirements will be assigned readings, an oral presentation and a final exam.
NOTE: Class size limited to 29
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3.00 Credits
1109 MOLECULAR APPROACHES TO DRUG ACTION AND DESIGN
COURSE LEADER: Dr. Nancy Carrasco
CREDITS/CLASS MEETINGS: 3 semester hours; approximately 28 lectures.
PREREQUISITE BACKGROUND: Should have the equivalent of graduate school biochemistry.
SUITABILITY FOR 1ST YEAR STUDENTS: This course is not intended for first year students. Consult with the course leaders if there are any questions.
COURSE DESCRIPTION: This course will involve a discussion of drugs employed in the treatment of bacterial, viral, fungal, and parasitic disease, cardiovascular and CNS pathology, diabetes, and cancer. The principles of pharmacokinetics, pharmacodynamics, and drug metabolism, and the design of enzyme inhibitors as drugs will be studied. The molecular mechanisms of drug resistance will be analyzed. Emphasis will be placed on the biology and chemistry of interactions between chemotherapeutic agents and their cellular targets, including the bacterial cell wall, cell membrane components, transport processes, DNA, the ribosome, the cytoskeleton, and specific enzymes and receptors.
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3.00 Credits
1111 VIROLOGY
COURSE LEADERS: Drs. Vinayaka Prasad, Ganjam Kalpana and Jurgen Brojatsch
CREDITS/CLASS MEETINGS: 3 semester hours; approximately 30 lectures.
PREREQUISITE BACKGROUND: Biochemistry, Gene Expression and Molecular Genetics courses are recommended, but not mandatory.
SUGGESTED BACKGROUND READING:
1. Principles of Virology Second edition by S.J. Flint, L.W. Enquist, R.M. Krug, V.R. Racaniello and A.M. Skalka (2004) ASM Press.
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3.00 Credits
1112 THEORY AND PRACTICE IN INHIBITOR DESIGN
Course Leaders:
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3.00 Credits
1113 GLYCOBIOLOGY
COURSE LEADER: Dr. Pamela Stanley
CREDITS/CLASS MEETINGS: 3 semester hours; one semester course; Approx.15 meetings of 1.52 hrs. Outside seminar speakers (occasional). Invited class leaders.
PREREQUISITE BACKGROUND: Undergraduate course(s) in Biochemistry; graduate course(s) in Biochemistry or Molecular Cell Biology, including pathways of complex carbohydrate biosynthesis recommended.
SUGGESTED BACKGOUND READING: Essential s of Glycobiology 2nd edition A. Varki et al. Pubmed NCBI Books. Published by Cold Spring Harbor Press.
SUITABILITY FOR 1ST YEAR STUDENTS: Only in exceptional cases. This course should be taken after taking the Biochemistry and Molecular Cell Biology graduate courses.
COURSE DESCRIPTION: The aim of this course is to provide students with a perspective on Glycobiology - the identification of functional roles for sugars covalently associated with protein and lipid in eukaryotes. Glycan binding proteins or lectins abound in mammalian cells and tissues. Glycosyltransferases that synthesize the glycan ligands of these lectins have been knocked out in mice and other organisms, and a molecular genetic approach to studies of function is well established. The increase in our knowledge of functional roles for cell surface and extracellular glycans in Drosophila, C. elegans, yeast, mice and humans, and the ability to investigate structure/function relationships with powerful biochemical techniques, has firmly established the field of Glycobiology.
The course will consist of about 15 sessions. Each session of 1.5 hours will involve a discussion by the lecturer to provide appropriate background information necessary to critically review a key paper from the literature. Students will be required to read the paper before the class and to be prepared to present and discuss the details in class. The topics chosen for presentation will focus on biological systems in which glycans play a functional role, and on the interests of students that make up the class. Topics discussed in previous years include: the molecular basis of a congential anemia; requirement for glycans in recombinant drugs such as erythropoietin; glycans that mediate cell-cell adhesion; glycosyltransferases that synthesize selectin ligands involved in inflammatory responses; functional roles for specific cell surface glycans in tumorgenicity and metastasis; lectins in mammalian tissues and apoptosis; a regulatory role for cytoplasmic glycosylation; roles of glycans during mammalian embryogenesis; biological roles for proteoglycans; biological roles for sugars in the action of glycoprotein hormones; role of glycans in HIV infection. The genome projects have revealed several hundred glycosyltransferase and glycan binding protein genes in mammals and genetic strategies are identifying their functions. Most recently sugars have been shown to play a direct role in signaling through Notch receptors, identifying a new paradigm for the regulation of signal transduction by glycosylation.
NOTE: IN ORDER FOR THIS COURSE TO BE GIVEN, A MINIMUM OF 6 STUDENTS MUST BE REGISTERED.
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3.00 Credits
1114 CANCER: A BASIC SCIENCE APPROACH
COURSE LEADERS:
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2.00 Credits
No course description available.
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