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  • 3.00 Credits

    (Cross-listed as Biology 162 and Biomedical Engineering 162.) Overview of key aspects of molecular biology and engineering aspects of biotechnology. Lecture topics include molecular biology, recombinant DNA techniques, immunology, cell biology, protein purification, fermentation, cell culture, combinatorial methods, and bioinformatics. Includes a semester-long technical project and oral presentation. (Also offered as lower-level.) Prerequisites Permission of instructor. This course is offered during the following semesters: Fall Semester
  • 3.00 Credits

    (Cross-listed as Biology 163 and Biomedical Engineering 163.) This lecture and laboratory course is designed to familiarize students with methods used to produce recombinant products. The lectures cover fundamental aspects of recombinant DNA methodologies used in the laboratory as well as some of the commercial applications of these techniques. The laboratory provides hands-on experience with the key skills used in genetic engineering, including DNA isolation, restriction enzyme mapping, cloning and selection, protein expression, gel electrophoresis, polymerase chain reaction, DNA sequencing, and related techniques. Cannot be taken for credit if Biology 50 is taken for credit. Prerequisites Permission of instructor. This course is offered during the following semesters: First Summer Semester
  • 3.00 Credits

    (Cross-listed as Biomedical Engineering 164 and Biology 174.) Synthesis, characterization, and functional properties of organic and inorganic biomaterials, and the process of tissue engineering are covered. Fundamental issues related to the utility of biomaterials are explored based on their biocompatibility, stability, interfaces, and fate in the body. Clinical applications for biomaterials are investigated, as are new directions in design and synthesis to achieve better biocompatibility. Testing methods, regulatory issues, legal constraints, and emerging research directions are also discussed. Prerequisites Permission of instructor. This course is offered during the following semesters: Spring Semester
  • 3.00 Credits

    (Cross-listed as Mechanical Engineering 111). Advanced topics in fluid mechanics. Viscous and inviscid flows. Strain rate, vorticity and streamline coordinates. Differential conservation laws for mass, momentum and energy. Dimensional analysis. Lubrication flows. Momentum and thermal laminar boundary layers. Laminar-turbulent transition. Reynolds stress and turbulence modeling. Turbulent boundary layers. Flow modeling. Prerequisites ES 8 - Fluid Mechanics or permission of instructor.
  • 3.00 Credits

    In-depth examination of microbial and mammalian cell cultivation and concomitant production of commercially important products. Mechanism and methods of measurement and quantitative analysis of growth, product formation, and nutrient utilization kinetics in characterizing and optimizing for cell mass or product formation. Discussion of fundamental parameters controlling bioreactor design and scale-up. Systems studied include production of proteins in recombinant organisms, antibiotics, amino acids, and the cultivation of mammalian cells. Prerequisites Permission of Instructor. This course is offered during the following semesters: Fall Semester
  • 3.00 Credits

    The goal is to present a framework for quantitative analysis of cellular functions, and introduce students to metabolic engineering. Metabolic engineering is a systems-oriented approach to the problem of remodeling and reconfiguring the many molecular components of the cell in order to achieve a desirable phenotype. Unlike molecule-centric approaches, which focus on only the final product-forming reaction, metabolic engineering emphasizes the metabolic pathway in its entirety. Course material analyzes cell-level processes as molecular systems. The processes to be discussed include: metabolism, protein synthesis, and regulation of gene expression. Analyses of these processes will emphasize an engineering, problem solving-oriented perspective, and will be integrated with discussions on core metabolic engineering methods: metabolic modeling, genetic engineering, and analytical biochemistry. Complementary disciplines very recently added to the metabolic engineering toolbox will also be discussed: 'omics' technologies, computational systems biology, and synthetic biology. Selected metabolic engineering applications, including conversion of biomass into fuels, will be further explored through case studies and reviews of the current literature.Prerequisites Open to graduate students and seniors. Backgrounds in biochemistry, numerical methods, and chemical kinetics is highly recommended.
  • 3.00 Credits

    (Cross-listed as Biology 168 and Biomedical Engineering 168.) Laboratory experience with techniques in biotechnology processing: fermentation of recombinant E. coli cells, hybridoma cell culture, purification of proteins and antibodies and related analytical procedures. Laboratories accompanied by lectures and relevant readings to cover the underlying principles. Counts as laboratory course for biology major. Prerequisites Permission of instructor. This course is offered during the following semesters: Spring Semester
  • 3.00 Credits

    (Cross-listed as Biology 169 and Biomedical Engineering 169.) Seminar course. Journal articles on current biotechnology-related research are reviewed. Leading researchers in the field present seminars, and students assess future research directions based on in-depth review of articles and presentations.
  • 3.00 Credits

    Survey of environmental problems arising from commonplace technologies, e.g., transportation, power generation, microelectronics processing, chemicals manufacturing. The course considers the introduction of chemicals into the environment and illustrates how to predict the fates of those chemicals in air-water-land-biota systems. Environmental and health consequences of products and the processes used for their manufacture are examined. Life Cycle Analysis methodologies are implemented in case studies. Development of technologies and policies for pollution prevention and a sustainable environment are discussed. Prerequisites Junior standing or permission of instructor.
  • 3.00 Credits

    (Cross-listed with Fletcher School.) This course considers current issues in power generation, identifying the technologies used to meet Clean Air Act regulations by the electric utilities and automobile manufacturers. Topics include the electric utility deregulation, distributed power sources, new energy markets, fuel efficiency, and global effects of fossil fuel use. Alternative fuels and engines will be examined from the point of view of technology readiness and global market penetration to curb air pollution and decrease carbon emissions. The costs of energy technologies and the global impacts of present policies in the U. S. and abroad will be evaluated. This course is offered during the following semesters: Spring Semester
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