CHBE 0167 - Metabolic&cellular Engin

Institution:

Tufts University

Subject:

Description:

The goal is to present a framework for quantitative analysis of cellular functions, and introduce students to metabolic engineering. Metabolic engineering is a systems-oriented approach to the problem of remodeling and reconfiguring the many molecular components of the cell in order to achieve a desirable phenotype. Unlike molecule-centric approaches, which focus on only the final product-forming reaction, metabolic engineering emphasizes the metabolic pathway in its entirety. Course material analyzes cell-level processes as molecular systems. The processes to be discussed include: metabolism, protein synthesis, and regulation of gene expression. Analyses of these processes will emphasize an engineering, problem solving-oriented perspective, and will be integrated with discussions on core metabolic engineering methods: metabolic modeling, genetic engineering, and analytical biochemistry. Complementary disciplines very recently added to the metabolic engineering toolbox will also be discussed: 'omics' technologies, computational systems biology, and synthetic biology. Selected metabolic engineering applications, including conversion of biomass into fuels, will be further explored through case studies and reviews of the current literature.Prerequisites Open to graduate students and seniors. Backgrounds in biochemistry, numerical methods, and chemical kinetics is highly recommended.

Credits:

3.00

Credit Hours:

Prerequisites:

Corequisites:

Exclusions:

Level:

Instructional Type:

Lecture

Notes:

Additional Information:

Historical Version(s):

Institution Website:

www.tufts.edu

Phone Number:

(617) 628-5000

Regional Accreditation:

New England Association of Schools and Colleges

Calendar System:

Semester

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