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Course Criteria
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3.00 Credits
This course will cover principles of toxicology and in depth special issues relating to drug overdose, heavy metal poisoning, prescription drug side effects, natural and OTC poisoning, as well as their treatment procedures. The role of poison control center triage of cases, ER treatment, suicide management and unique considerations therein, and characteristic toxic profiles of drug classes will be described. Medico-legal issues associated with toxicology will also be discussed. [3]
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2.00 Credits
This course will describe in detail the derivation and theory of pharmacokinetics. This course picks up where the general survey course given in PHR 501 leaves off and describes the mathematical constructs behind PK measures as well as in depth discussion of two and multicompartment models. Upon completion of this course the trainee will be able to design and analyze results from a Phase I and II trials involving a drug acting in two compartments. (2 Credits)
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1.00 Credits
The literature on drug abuse will be surveyed. Areas of emphasis will include the role of DA in addiction, the concept of the addictive personality and the genetics of addiction, the neurobiology of incentive salience, dissociation of tolerance from euphorogenic effects, history of addiction theory, and the unique aspects of various drugs of abuse. The ethics of chronic pain management in the clinical setting will also be discussed. (1 Credit)
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3.00 Credits
This survey course describes in detail all aspects of performing clinical drug trials. It includes extensive discussion on IND applications, how drug studies differ from other types of studies, GLP certification procedures, informed consent procedures involving drugs, the characteristics of Phase I-IV studies and the special considerations involved with each, packaging and delivery considerations, role of the pharmacokineticist in the design and implementation of these studies, sample and data collection procedures, FDA oversight considerations, data analysis and interpretation, and laboratory responsibilities after the study is completed. [3]
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3.00 Credits
The course is designed to allow the student flexibility in independently pursuing a particular area of interest. May be taken for one or more terms. [variable hours]
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3.00 Credits
This course is designed to provide the practical aspects of proposal submission. In addition to covering basic writing skills, it addresses specific elements that should be included in each of the various sections of federal grants, foundation applications, and biotech contracts. In addition, it talks about ways of identifying sources for funding, a survey of the NIH landscape and how to prepare budgets. The online submission process is also reviewed. [2]
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2.00 Credits
This practicum involves actual patient contact time in the clinical pharmacology units within Rush as well as the Chicagoland area. The practice is designed to expose the clinical scientist to the practical aspects of conducting clinical pharmacology research in both an academic and commercial setting. Seminars on recruitment procedures, study coordinators, specialty needs, and dealing with special populations will be provided. (2 Credits)
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3.00 Credits
A minimum of 8 research hours must be completed. This will involve actual time collecting data in a clinical pharmacology study either as part of an individual's own project or in collaboration with a mentor. As part of the requirements of this research, the investigator will have to either write an IND or a drug company research proposal as well as complete a written thesis and defend it publicly. [variable hours/quarter]
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3.00 Credits
Laboratory research in an area of interest that will form the basis of a dissertation proposal or a master's thesis. These research hrs are taken prior to passage of comprehensive exams. By special arrangement. [variable hours/quarter]
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3.00 Credits
Advanced laboratory courses focuses on techniques used in preparing experimental methods/models for research. By arrangement only. [1-3]
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