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Course Criteria
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0.00 - 4.00 Credits
Broad introduction to major contemporary techniques used to study structures, functions, and interactions of biological macromolecules, including quantitative theory of molecular interactions. Aims to convey to students with diverse backgrounds and interests the utility of various experimental methods for solving molecular problems. Emphasis is on applications, practical aspects, and experimental design, and on strengths and limitations of individual methods and complementarities among them.
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0.00 - 4.00 Credits
To familiarize the student with basic principles of structure and reactivity of transition metal organometallic chemistry.
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0.00 - 4.00 Credits
This course explores the theory and practice of modern techniques in electrochemistry. Physical chemistry of charge transfer is considered, as well as applications in the areas of electroanalytical chemistry and photoelectrochemistry. Key laboratory techniques, such as cyclic voltammetry, chronoamperometry and rotating disk voltammetry are a focus of the course.
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0.00 - 4.00 Credits
A mechanism-based course on organic synthesis for advanced undergraduates and beginning graduate students who wish to learn chemical synthesis of organic compounds. Course deals with various classical and modern synthetic methodologies. Particular emphasis is placed on understanding scope, limitations, and selectivity based on the mechanism, with the goal to understand fundamental principles underlying each synthetic method. The knowledge and perspective acquired in this course is expected to provide sufficient foundation to understand and use the research literature in organic synthesis.
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0.00 - 4.00 Credits
An in-depth discussion of transition metal-catalyzed reactions commonly used in modern organic synthesis (e.g. cross coupling, olefin metathesis, asymmetric hydrogenation, etc.). Emphasis will be placed on the topic of selectivity (chemo-, regio-, and stereo-) and its mechanistic basis. The historical development, scope, and limitations of the methods are discussed. A prior course in organometallic chemistry (CHM 521) is recommended.
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0.00 - 4.00 Credits
This class emphasizes the use of chemical approaches to investigate and manipulate biological processes at the biochemical, the cellular, and the organismal level. The purpose is to provide biologists with modern chemical methods, and chemists with important questions in biology. Grades are based on problem sets, a literature presentation, a research proposal, and reviews of other research proposals during the in-class "study sections."
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0.00 - 4.00 Credits
The application of instrumentation (chiefly spectrometers) to modern chemical and biochemical research, including medicinal chemistry will be covered. Primary emphasis will be on NMR methods, including data processing and spectrum analysis, but additional sections of the course will be devoted to mass spectrometry , X-ray diffraction, IR, UV, and EPR spectroscopy, as well as chiroptical techniques. The integrated nature of using various instrumental methods for identification and characterization of molecular structure and dynamics will be emphasized.
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0.00 - 4.00 Credits
This course will be taught from the scientific literature. We will begin the semester with several classic papers on protein folding. As the semester progresses, we will read about protein structure, stability, and folding pathways. The latter part of the semester will focus on recent papers describing new research aimed toward the construction of novel proteins from "scratch." These papers will cover topics ranging from evolution in vitro to computational and rational design. The course will end by discussing the possibility of creating artificial proteomes in the laboratory, and further steps toward synthetic biology.
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0.00 - 4.00 Credits
A critical discussion of biological structures pertinent to understanding neurodevelopmental diseases. Crystal structures of ion channels, synaptic scaffolds, receptors, chromatin remodeling complexes, and kinases will be analyzed in the context of recent genetic findings on the causes of autism, fragile-X syndrome, and Rett's syndrome. A systems biology approach will be taken to bridge the gap between behavioral phenotypes, as studied with mouse models, and gene expression profiles. The principles of x-ray crystallography will be taught as needed to follow journal articles under discussion.
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0.00 - 4.00 Credits
Life processes depend on over 25 elements whose bioinorganic chemistry is relevant to the environment (biogeochemical cycles), agriculture, and health. CHM 544 surveys the bioinorganic chemistry of the elements. In-depth coverage of key transition metal ions including manganese, iron, copper, and molybdenum focuses on redox roles in anaerobic and aerobic systems and metalloenzymes that activate small molecules and ions, including hydrogen, nitrogen, nitrate, nitric oxide, oxygen, superoxide, and hydrogen peroxide. Appreciation of the structure and reactivity of metalloenzyme systems is critical to understanding life at the molecular level.
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