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Course Criteria
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3.00 Credits
A survey of the structural components of biomembranes and the forces that dictate membrane structure. General membrane functions, such as compartmentalization and membrane transport, are analyzed in view of the principles of membrane structure. The structure, function, and biogenesis of the membrane organelles in cells are covered in detail. Diseases whose pathology originates with biomembranes, such as cystic fibrosis and heart disease, are discussed as examples illustrating membrane structure and function. Prerequisites: BIOL 3301, BIOL 3302, and BIOL/CHEM 3361 and BIOL/CHEM 3362 or their equivalents, or the written consent of the instructor. (3-0) T
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3.00 Credits
Theoretical and experimental papers in selected areas of biology will be discussed in a senior seminar format. The historical and biographical context of the papers and their authors will also be explored. The areas to be covered in any semester will vary with the instructor. Each student is expected to make an oral presentation and to prepare a written paper. Satisfies the Advanced Writing Requirement for Biology majors. Prerequisites: BIOL 3301, BIOL 3302, BIOL/CHEM 3361, and BIOL/CHEM 3362. (3-0) S
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3.00 Credits
How cells sense, interpret, and respond to various intra- and extracellular signals. Focus will be placed on signal transduction pathways controlling growth, development, and diseases. The course will consist of lectures and in-class discussion of research articles. Prerequisites: BIOL 3301, BIOL 3302, and BIOL/CHEM 3361 or their equivalents, or the written consent of the instructor. (3-0) T
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3.00 Credits
Covers the modern techniques for analyzing the protein complement of cells, to understand cell development and physiology in healthy and diseased states. Topics include protein isolation techniques; IEF-SDS PAGE; protein structure determination by X-ray crystallography and NMR; techniques for identification of protein interactions; the use of mass spectrometry to quantitate, sequence, and identify post-translational modifications of proteins; the development of protein chips and how they can be used for protein identification and quantitation. Prerequisite: BIOL/CHEM 3361. (3-0) T
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3.00 Credits
Fundamentals of how the human genome sequence was acquired and the impact of the human genome era on biomedical research, medical care and genetic testing. Also covered is the impact new tools such as DNA microarray, realtime PCR, mass spectrometry and bioinformatics will have on approaches to how scientific questions are investigated. The class will be a mixture of didactic lectures and paper presentations on examples of applied genomics. There will be two computer-based labs where students will perform online bioinformatics and data mining using the NCBI public database. Prerequisite: BIOL 3301 with a grade of C or better. (3-0) T
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3.00 Credits
How genetic information is regulated in prokaryotic and eukaryotic systems. Topics include mechanisms of transcription, promoter architecture, function and regulation of transcription factors, organization of chromosomes, pathways that control gene expression during growth and development, genome organization and whole-genome expression analysis, and related areas. The course emphasizes presentation and critical discussion of techniques and results from the recent scientific literature. Prerequisites: BIOL 3301, BIOL 3302, and BIOL/CHEM 3361 or their equivalents, or the written consent of the instructor. (3-0) T
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3.00 Credits
Interactions of antigens and antibodies. Fine structure of antibodies. Tissues and cells of the immune system. Response of B and T lymphocytes to antigens. Cellular interactions in humoral and cell-mediated immunity. Genetic basis of antibody diversity. Immunity and infectious diseases. Prerequisites: CHEM 2323 and CHEM 2325 (Organic Chemistry I and II). Suggested additional preparation: BIOL 3302. (3-0) T
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3.00 Credits
This course will cover the methods used for identification of pathogenic organisms and the study of these organisms in relation to their disease process in humans. We will also cover at the molecular level important concepts such as microbial virulence, the control of bacterial growth, and host responses to infection. Prerequisite: BIOL 3301 or BIOL 3420. (3-0) T
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3.00 Credits
Topics related to health and disease will be examined from a molecular and cellular perspective. Topics will vary but will be selected from new and developing applications of cell biology to cancer, heart disease, fat metabolism, mitochondrial disorders, aging, Alzheimer's, etc. Students are expected to participate actively in discussions and make an oral presentation. Prerequisite: BIOL 3302. (3-0) T
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3.00 Credits
Topics include a discussion of the history and epidemiology of AIDS, the likely origins of human immunodeficiency virus (HIV), and the molecular and cell biology of HIV replication. The cell biological basis of the immunodeficiency induced by HIV infection is examined, as well as that of common accompanying pathologies such as Kaposi's sarcoma. The molecular basis of a variety of existing and potential anti-viral therapies is considered. Suggested prerequisite: BIOL 3302. (3-0) T
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