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Course Criteria
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1.00 Credits
Laboratory rotation for first year Immunology graduate students, first semester. Department consent required. Instructor: Staff
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1.00 Credits
Laboratory rotation for first year Immunology graduate students, second semester. Department consent required. Instructor: Staff
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3.00 Credits
Course will integrate empirical and computational perspectives on immunology and host defense. Students are expected to have significant preparation in either biomedicine or a quantitative science. Topics covered are intended to provide an entree into the use of computational methods for research and practice in immunology and infectious disease, from basic science to medical applications. Consent of instructor required. Instructors: Kepler and Cowell
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3.00 Credits
An introduction to the molecular and cellular basis of the immune response. Topics include anatomy of the lymphoid system, lymphocyte biology, antigen-antibody interactions, humoral and cellular effector mechanisms, and control of immune responses. Prerequisites: Biology 119 and Chemistry 151L or equivalents. Instructors: He and Zhang
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2.00 Credits
Principles of modern structural biology. Protein-nucleic acid recognition, enzymatic reactions, viruses, immunoglobulins, signal transduction, and structure-based drug design described in terms of the atomic properties of biological macromolecules. Discussion of methods of structure determination with particular emphasis on macromolecular X-ray crystallography NMR methods, homology modeling, and bioinformatics. Students use molecular graphics tutorials and Internet databases to view and analyze structures. Prerequisites: organic chemistry and introductory biochemistry. Instructors: Beese and staff
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2.00 Credits
Continuation of Biochemistry 258. Structure/function analysis of proteins as enzymes, multiple ligand binding, protein folding and stability, allostery, protein-protein interactions. Prerequisites: Biochemistry 258, organic chemistry, physical chemistry, and introductory biochemistry. Instructors: Hellinga and staff
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2.00 Credits
Mechanisms of transcription, splicing, catalytic RNA, RNA editing, mRNA stability and translation. Mini-course, 2nd half semester. Instructors: Steege and Staff
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2.00 Credits
An advanced seminar course covering selected aspects of current research on biogenesis and dynamics of various cellular membranes. Emphasis will be on the cell biology of the immune system. Discussion topics will represent the following areas: biosynthesis of membrane proteins; intracellular transport vesicles; endocytosis; signal transduction across the plasma membrane; intracellular organelles and protein sorting; cell interactions in differentiation. Prerequisite: Microbiology 269 or consent of instructor. Instructor: Staff
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3.00 Credits
Intended for basic scientists and physicians. Advanced study of immune-mechanisms central to human disease including localized and systemic autoimmunity, transplantation tolerance, allergy and asthma, and immunodeficiency syndromes. Lectures detail cellular- and molecular immune mechanisms that effect specific pathologies. Offered biennially (in rotation with IMM 300). Prerequisites: IMM 244, IMM 291, or equivalents. Consent of instructor required. Instructor: St. Clair and Kelsoe
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2.00 Credits
This course will cover the immune aspect of host-pathogen interaction at both the molecular and cellular levels. Topics include innate immune responses to pathogens such as pattern recognition receptors and effector mechanisms of innate immunity, adaptive immune responses to bacterial, viral and fungal infections, pathogenic strategies for subversion of immune responses and immunopathology, vaccine development to emerging and re-emerging infectious disease. The current understanding of host immune responses to specific pathogens including HIV, HBV, HVC, Malaria, and Mycobacterium tuberculosis will be discussed. Prerequisites: IMM244. Instructor: He and staff. 2 units
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