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Course Criteria
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1.00 Credits
Introduction to various conceptions of liberty in Greek and Roman political and philosophical writing. Considerations of such questions as: what is distinctive about the modern conceptions of political and civil liberty; whether there is any necessary ethical connection between liberty and virtue, or whether there is liberty and active citizenship, or liberty and privacy; whether ancient conceptions of liberty can still serve as a model in contemporary politics and should be considered exemplary or inferior to modern conceptions of freedom. Open only to students in the Focus Program. Instructor: Grant
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1.00 Credits
The tragedies and comedies of the fifth-century theater as a window on Athens: the conventions and public context of performance; the plays as indicators of social values, debates, and limits; the literary consciousness of authors and audience. Open only to students in the Focus Program. Instructor: Burian
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2.00 Credits
The use and importance of statistical methods in laboratory science, with an emphasis on the nuts and bolts of experimental design, hypothesis testing, and statistical inference. Central tendency and dispersion, Gaussian and non-Gaussian distributions, parametric and nonparametric tests, uni- and multivariate designs, ANOVA and regression procedures. Ethical issues in data handling and presentation. Student presentations in addition to formal lectures. Intended for third-year graduate students. Instructor: Slotkin
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2.00 Credits
Fundamentals of DNA replication, transcription, and translation. Transcriptional and translational regulation mechanisms. Consent of instructor required for undergraduates. Second half of fall semester. Instructor: MacAlpine and Yao
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4.00 Credits
This class covers a wealth of cell and molecular biology in a modular format, with modules focusing on either critical discussion of primary literature, developing quantitative/mathematical approaches to the biology, or both. Each module consists of five or six classes. Students select six (non-concurrent) modules; each module contributes to 10% of the final grade. At the end of the class, students develop a research proposal with an assigned faculty coach. All proposals are presented to the class in a 2-day symposium, contributing 40% of the final grade. Undergraduates require permission of coordinator to enroll. Instructors: Lew and Nicchitta
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2.00 Credits
Principles of modern structural biology. Protein-nucleic acid recognition, enzymatic reactions, viruses, immunoglobulins, signal transduction, and structure-based drug design described in terms of the atomic properties of biological macromolecules. Discussion of methods of structure determination with particular emphasis on macromolecular X-ray crystallography NMR methods, homology modeling, and bioinformatics. Students use molecular graphics tutorials and Internet databases to view and analyze structures. Prerequisites: organic chemistry and introductory biochemistry. Instructors: Beese and staff
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2.00 Credits
Fundamental laboratory techniques in basic research in two sections: 1. protein purification, analysis, and the study of protein interactions; 2. nucleic acid techniques, a review of basic nucleic acid chemistry, enzymatic modification, qualitative and quantitative PCR, DNA sequencing, cloning, vectors, and expression analysis including microarray techniques. A team-based learning model: course reading material and recorded lectures are reviewed before class, while in class the material is reinforced through problem sets and group discussion. Consent of instructor required for undergraduates. First half of fall semester. Instructor: Datto
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2.00 Credits
The use and importance of statistical methods in laboratory science, with an emphasis on the nuts and bolts of experimental design, hypothesis testing, and statistical inference. Central tendency and dispersion, Gaussian and non-Gaussian distributions, parametric and nonparametric tests, uni- and multivariate designs, ANOVA and regression procedures. Ethical issues in data handling and presentation. Student presentations in addition to formal lectures. Intended for third-year graduate students. Instructor: Slotkin
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4.00 Credits
Use of genetic approaches to address research problems in cell and developmental biology. Genetic fundamentals build up to modern molecular genetic strategies including genetic screens, reverse genetics, genetic interactions, dominant negative mutants, and more. Several major genetic model organisms used to illustrate general principles. Consent of instructor required for undergraduates. Instructor: Lew
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4.00 Credits
This basic course in family medicine consists of an four-week clinical clerkship in the second year. The course goal is to provide students with an understanding of the principles of family medicine and how these apply in community practice. The course emphasizes continuous and comprehensive health care for people of both sexes and all ages within the context of their social groups and communities. Particular attention is paid to the diagnosis and treatment of common medical problems and to health maintenance, ambulatory care, continuity of care, and the role of consultants in primary care. Other topics covered include social factors such as the doctor-patient relationship, the role of the physician in the community, and the economics of health care delivery. Students are placed with community-based faculty who are practicing family physicians in communities outside of Durham, principally within North Carolina. Most of these preceptorship sites are in rural communities, providing students with exposure to many issues of rural health care such as farming and other occupational injuries, transportation difficulties, and local customs. The eight-week sites are scheduled based on the availability of the preceptors. These sites may not be available every rotation. Students gain extensive experience in diagnosing and managing patient problems in an ambulatory care setting under the guidance of the department's faculty. In addition, the clerkship provides students with opportunities to see patients in a variety of other settings, including home, nursing home, and community hospital. There is also the opportunity for medical students to be paired with physician assistant students at a community practice site for the purpose of working with mid-level practitioners in a team practice setting. Note: COMMFAM-205C is strongly recommended for all students in the primary care program. Changes in the rotation are not made less than 12 weeks prior to the start of the rotation. Credit: 4. Joyce Copeland, MD
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