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Course Criteria
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3.00 Credits
This course is designed to allow students to become acquainted with the use of the single crystal X-ray diffraction to solve and refine small molecule crystal structures. Students will learn basic crystallographic theory and terminology, which will allow for an understanding of the diffractometer operation, the data collection process, as well as the structure solution and refinement procedures. Topics such as Bravais lattices, Bragg¿s law, crystallographic space groups and reciprocal space will be discussed.
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3.00 Credits
This course will cover selected instrumental analysis techniques in depth. Primary coverage will be on analytical techniques that are most relevant to modern chemical analysis, such as mass spectrometry. Modules and particular emphasis in mass spectroscopy will be on advanced topics such as stable isotope mass spectrometry and atmospheric pressure ionization techniques ESL and MALDI and ICP. Other hyphenated and independent modules on liquid chromatrography, speciation separation, advanced sample preparation for instrumental analysis and IDMS and capillary-based separation techniques and microfluidics, optical spectroscopy and chemical imaging, and other methods will also be included. The course will be team taught with modular instructive and problem based use of instrumental equipment being employed.
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3.00 Credits
This course provides students with an appreciation and understanding of the background, theoretical, fundamental, and advanced modern Mass Spectrometry. The class explores allied chemistries and applications in mass spectrometry. Students will learn current mass spectrometric application areas such as proteomics, speciation metabelomics, epigenomics, immunochemical, bioinformatics, atomic spectrometry and clinical applications. Current and emerging mass spectrometric and modern interfaces, ionization, and automation configurations will be explored. Students will learn applications and testing methods used in analytical chemistry, bioanalytical chemistry, biochemistry and clinical MS analysis.
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3.00 Credits
The course is a detailed look at transition metal organometallic chemistry. Areas that will be covered inlclude bonding theory, synthesis and reactivity of sigma-bonded alkyls and aryls, metal carbonyls and pi-bonded organic ligands such as alkenes, alkynes, allyls, and arnes. This course will also discuss applications of organometallic complexes in organic synthesis and industrial catalysis.
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3.00 Credits
Enzyme Mechanisms and Biotransformations. Course emphasized molecular mechanisms of enzyme catalyzed reactions and the application and role of these reactions in natural product biosynthetic pathways.
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3.00 Credits
Covalent Bond Reaction Chemistry. Continuation of CHEM 551. Course covers aspects of organic and inorganic reaction mechanisms, emphasizing reaction of central importance to the fields of biological, inorganic, and organic chemistry.
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2.00 Credits
Organometallic Chemistry. Continuation of CHEM 552. This course emphasized chemical bonding in organometallic compounds and the use of organometallic reagents as catalysts in chemical synthesis.
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3.00 Credits
Course covers classical thermodynamics and equilibrium, including interfacial equilibrium and transport mechanisms. The kinetics module includes classical solution and gas phase kinetics as well as enzyme kinetics.
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3.00 Credits
Continuation of CHEM 584. Topics include statistical thermodynamics and kinetics, interfacial kinetics, and the kinetics of electron transfer reactions.
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3.00 Credits
Quantum Chemistry and Group Theory. Course emphasized current concepts of atomic and molecular structure. Topics include modern methods in quantum theory and group theory as applied to molecular symmetry, orbital symmetry, and applied spectroscopy.
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