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Course Criteria
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2.00 Credits
No course description available.
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3.00 Credits
The purpose of this course is to foster basic understanding of the solid state and relevant analytical techniques for its characterization. Theory will begin by addressing atomic solids, with an eventual emphasis on small molecular organic materials. Topics within this course include solidification, nucleation and growth, surface properties, diffusion processes and solid state reactions/reactivity, crystalline polymorphism, the amorphous solid state, deformation processes, and mechanical properties of consolidated bodies.
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3.00 Credits
A course concerned with basic theoretical principles and the application to chemical and pharmaceutical systems of chromatographic methods of analysis. Practice is given in the use of the various instruments according to the student's past experience in the major field.
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3.00 Credits
A course concerned with interpretation of ultraviolet, infrared, nuclear magnetic resonance, and mass spectra. Discussions and correlation of spectra with structure of organic molecules are included. Demonstration and laboratory practice of ultraviolet, infrafed and nuclear magentic resonance spectrometry application. Class, three hours; labatory, one hour.
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3.00 Credits
No course description available.
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3.00 Credits
No course description available.
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3.00 Credits
A course, which introduces common chemometric routines, used for evaluation of multivariate data and the application of these methods in the solution of practical chemical and spectroscopic problems arising from actual laboratory results. Lecture-computer lab, three hours.
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4.00 Credits
This course applies the concepts covered in Principles of Drug Action, Design, and Delivery to issues concerning drug solubility, drug-receptor interactions, stereochemical aspects of drug action, and basic concepts in molecular modification (homolagation, fragmentation, molecular hybridization, isosteric substitutions). Advanced concepts discussed include: receptor interactioins, QSAR, approaches to the rational design of enzyme inhibitors, the relationship of drug metabolism to drug design, the design of prodrugs, the design, execution and analysis of combinational libraries. Recent advances in specific areas relating to molecular modeling as applied to the design of drugs, direct and indirect computer-aided ligand design, the pharmacophore concept and its use, the receptor-excluded and receptoressential volumes, solvation effects, and examples of 3D-pharmacophores and their use, will be presented.
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3.00 Credits
This course presents the physical, chemical, and medicinal chemical aspects of aromatic heterocyclic compounds, based on a prior understanding of modern structure identification techniques and of mechanistic organic chemistry. An emphasis will be placed on nomenclature, organic chemistry, and relevance to drug action.
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3.00 Credits
A lecture and laboratory demonstration course dealing with the multidisciplinary aspects of toxicology with emphasis on the biological test methods for toxic substances and the general clinical and analytical procedures used by the toxicologist. Food and Drug Administration regulations and suggested tests are also considered. Lecture, three hours. Alternate years.
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