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Course Criteria
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4.00 Credits
This laboratory course provides a multifaceted view of the cell, with the opportunity for new discovery, through microscopic imaging of a cell's response to environmental changes. We will identify yeast gene products that undergo changes in expression or subcellular localization after simple environmental perturbations or drug treatments. Students will be trained in basic molecular biological methods, including recombinant DNA manipulation, and basics of functional genomic resources. Enrollment is limited to first year students in MCS. Special permission required.
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6.00 Credits
The goal of this course is to provide an understanding of the nuts and bolts of biological experimentation. We will discuss the molecular principles behind the wide variety of experiments that were used to discover how cells work. The first half of the class will be a lecture based discussion of key experimental methods used in biological research. The second half of the class will be dedicated to group projects that create "story boards" to explain in molecular terms how these experiments work. The story boards will be used by modelers at the Pittsburgh Supercomputing Center to generate high-end animations of these experimental processes. This will prepare students for working in research labs and biology courses beyond "Modern Biology". This course is limited to first year students in MCS.
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1.00 - 3.00 Credits
The purpose of this seminar series is to update biology undergraduates about university and departmental functions, seminars, etc. that are pertinent or useful. In addition, research talks by faculty and undergraduates will be used to introduce students to the research being conducted in faculty laboratories. Additional topics may include graduate and medical school applications, career options, topics in the press, and important scientific discoveries.
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1.00 - 3.00 Credits
No course description available.
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6.00 Credits
The goal of this mini-course is to provide students with a general background about the process of taking a regenerative therapeutic from the bench to the bedside. A target clinical indication will be identified, for example, enhanced fracture healing in the distal radius of a post-menopausal osteoporotic patient. We will produce a regenerative therapeutic for that clinical indication and progress through the bench to bedside design and development. Students will be exposed to the process where each component and the final product will be tested using standard in vitro and in vivo protocols. The goal will be accomplished through lectures and library assignments.
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9.00 Credits
This laboratory course is designed to provide students with the ability to make measurements on and interpret data from living systems. The experimental modules reinforce concepts from 42-101 Introduction to Biomedical Engineering and expose students to four areas of biomedical engineering: biomedical signal and image processing, biomaterials, biomechanics, and cellular and molecular biotechnology. Several cross-cutting modules are included as well. The course includes weekly lectures to complement the experimental component. Prerequisites: 42-101 Introduction to Biomedical Engineering and 03-121 Modern Biology. Priority for enrollment will be given to students who have declared the Additional Major in Biomedical Engineering. Notes: This course number is reserved for students registered with the HPP program that, are CIT majors. If you require a biology lab for pre-health admissions requirements, please contact Dr. Conrad Zapanta and Dr. Maggie Braun (in the same email) for permission to register for 03-206 instead of 42-203. Priority for enrollment will be given to students who have declared the Additional Major in Biomedical Engineering.
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1.00 - 12.00 Credits
Students will read papers from the original literature under the direction of a faculty member. Students will be required to demonstrate mastery of the readings by discussions with the sponsoring faculty member, oral presentations, or writing of one or more papers summarizing and extending the information in the readings. If appropriate, students may write a program(s) to satisfy this last requirement. A student may take this course only once. This is a mini format course. Special permission required.
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9.00 Credits
This course provides an introduction to molecules and processes found in living systems. Amino acids, sugars, lipids and nucleotides and their corresponding higher structures, the proteins, polysaccharides, membranes and nucleic acids are studied. Kinetics and mechanisms of enzymes as well as elementary metabolic cycles and the energetics of biological systems are discussed.
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9.00 Credits
This course provides an introduction to the application of biochemistry to biotechnology. The functional properties of amino acids, nucleotides, lipids, and sugars are presented. This is followed by a discussion of the structural and thermodynamic aspects of the organization of these molecules into higher-order structures, such as proteins, nucleic acids, and membranes. The kinetics and thermodynamics of protein-ligand interactions are discussed for non-cooperative, cooperative, and allosteric binding events. The use of mechanistic and kinetic information in enzyme characterization and drug discovery are discussed. Topics pertinent to biotechnology include: antibody production and use, energy production in biochemical systems, expression of recombinant proteins, and methods of protein purification and characterization. The course is an alternate to 03-231.
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9.00 Credits
This course provides descriptive information and mechanistic detail concerning key cellular processes in six areas: membrane function, protein targeting, signaling, cytoskeleton, cell division, and cell interaction. An attempt is made to introduce the methodology that was used to obtain this information and to discuss how our understanding of these processes relates to the treatment of human disease.
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