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Course Criteria
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6.00 Credits
This lab is a capstone course requiring students to develop experimental protocols to accomplish assigned experiments involving advanced techniques in instrumental analysis. Library, literature and textbook research will be required. Upon agreement with instructor, two to four major experimental techniques will be required. (1014-441, 445; corequisite 1008-511 or 711) Lab 6, Credit 2 ( F, W-X*)
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1.00 Credits
This course will explore biochemistry and related biochemical sciences. It will include discussion of biochemistry-related opportunities including research, co-op, and careers. The biochemistry curriculum and biochemical resources will also be discussed. Class 1, Credit 1 (F)
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1.00 Credits
This course describes the fi eld of biochemistry in relation to the traditional fi elds of biology and chemistry. Biochemical approaches to problems in medicine, industry and forensics are presented. Students identify a topic of current interest that is related to biochemistry and present it to the class as a skit or dialogue. Issues of ethical concern also are discussed. (1013-231 or 1013-431) Class 1, Credit 1 (F)
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3.00 Credits
This course provides a foundation for the biochemistry course sequence and for participation in undergraduate research in biochemistry. The relationship between the three-dimensional structure of proteins and their function in oxygen transport and enzymatic catalysis is examined. In preparation for the next course in the sequence (1009-503 Biochemistry: Metabolism), membrane structure and the physical laws that apply to metabolic processes are also discussed. (1013-233 or 1013-433, or permission of instructor) Class 3, Credit 3 (F, W, S)
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3.00 Credits
Introduction to the metabolic pathways used for energy production and for the synthesis and degradation of the building blocks of living organisms. The pathways are presented individually, then integrated to show the balance between pathways; for example, the products generated by one pathway that are necessary for a second pathway. The effi ciency of chemical synthesis in biological organisms is discussed. Finally, the metabolic basis of selected diseases is examined. (1009-502 or permission of the instructor) Class 3, Credit 3 (F, W, S)
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3.00 Credits
Nucleic acid structures, including the classical Watson-Crick DNA secondary structure, as well as more recently discovered forms, are described. Nucleic acid metabolism and the fl ow of genetic information including replication of DNA, its transcription into RNA and the translation of messenger RNA into protein, as well as regulation of gene expression in prokaryotes are presented. DNA sequencing and recombinant DNA techniques having practical applications in medicine, agriculture and forensics are described. The nucleic acid biochemistry of viruses and oncogenes is surveyed. (1009-502) Class 3, Credit 3 (F, W, S) *X, extended day (after 5 p.m.)
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3.00 Credits
An introduction to the theory and practice of modern experimental biochemical laboratory techniques and concepts. The weekly one-hour lecture provides a theoretical framework for the course and includes a discussion of the properties of biomolecules and how those properties are exploited in the separation and characterization of the molecules. Practical laboratory techniques include the preparation of buffers, centrifugation, gel exclusion chromatography, electrophoretic methods, and UV-visible and fl uorescence spectrophotometry as applied to the isolation and characterization of proteins and nucleic acids. The manipulation of genetic material in E. coli will also be examined. Class 1, Lab 3, Credit 2 (F, W)
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3.00 Credits
In this course, we will analyze protein structure-function relationships. We will investigate how proteins function and how the structure relates to that function. The principles that explain enzyme rate enhancements, mechanistic enzymology will be examined. We will also explore protein superfamilies for phylogenetic relationships to enhance our understanding of protein structure function relationships. We will do this by reading and discussing current scientifi c literature and classic papers. (1009-502) Class 3, Credit 3 (S)
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3.00 Credits
Faculty-directed student projects or research in biochemistry, usually involving laboratory work and/or calculations that would be considered original. (Permission of research adviser) Class variable, Credit variable (F, W, S, SU)
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3.00 Credits
Faculty-directed student projects or research in biochemistry, usually involving laboratory work and/or calculations that would be considered original. (Permission of research advisor) Class variable, Credit variable (F, W, S, SU)
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