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Course Criteria
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6.00 Credits
The course will explore two facets of protein molecules: their structure and their expression. The structure component will build upon information from the Bioinformatics course and will add further sophistication with analysis of intermolecular interactions and ligand/receptor pairing. Software that permits molecular docking experiments will be employed. Tissue-specifi c protein expression will be addressed in lectures with description of micro-array technology and, in the laboratory, with two-dimensional protein gel electrophoresis. (1001-492, 493) Lab 6, Credit 4 (S)
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0.00 Credits
Cooperative education experience for undergraduate biological sciences students. Credit 0 (offered every quarter)
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3.00 Credits
The lecture material covers in depth the molecular and cellular events of antigen processing, recognition of antigen by T lymphocytes and their subsequent activation. The two distinct processing pathways for exogenous and endogenous antigens will be contrasted, in regards to intracellular compartments, proteolytic mechanisms and site of assembly with the major histocompatibility complex (MHC) molecules. Distinctions in maturation and transport to the cell surface of the two classes of peptide-loaded MHC molecules will be discussed. The structure, genetics, polymorphism and cell surface expression of MHC molecules will be covered. The intracellular events that occur following antigen recognition, and the two-signal model for T cell activation will be presented. The phenomenon of positive/negative selection within the thymus during T cell differentiation will be covered. (1001-350, 402) Class 3, Lab 3, Credit 4 (S)
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4.00 Credits
This course serves as an overview of gene expression in eukaryotic systems, with an emphasis on how disease can result when gene regulation is disrupted. Points of control that will be examined include: chromatin structure, transcription initiation, transcript processing, stability and modifi cation, RNA transport, translation initiation, post-translational events, and protein stability. The mechanisms involved in regulation at these control points will be discussed by exploring specifi c well studied cases. The signifi cance of these processes will be highlighted by a discussion of several diseases that have been shown to be due to defects in gene regulation. (1001-350, 1001-421) Class 4, Credit 4 (F)
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3.00 Credits
An introduction to bioremediation focusing on the interactions between engineers, chemists, biochemists, hydrologists, agronomists, and microbiologists to develop, design, and implement strategies to remediate soils or waters contaminated with various pollutants. The course will include topics in site assessments, risk assessments, characterization of contaminated sites, economics of remedial design, in situ processes, and ex situ processes. (1001-404 or permission of instructor) Class 3, Lab 3, Credit 4 (S)
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2.00 Credits
The seminar consists of written and oral reports and their discussion by class members covering topics of current interest in the biological sciences. (40 quarter credits in biology and successful completion of the departmental writing requirement) Class 2, Credit 2 (W, S)
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3.00 Credits
This course focuses on the mathematical modeling of population genetics and the implication for studies of human genetic diversity. Emphasis is placed on the use of these models in medical research, forensics, and pharmacogenomics. Labs apply the lecture material in computer simulation models using Excel. (1001-421 or equivalent; or permission of instructor) Class 3, Lab 3, Credit 4 (F)
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3.00 Credits
Special topics are advanced courses of current interest and/or logical continuations of the courses already being offered. These courses are structured as ordinary courses and have specifi ed prerequisites, contact hours and examination procedures. Class variable, Credit variable ( offered upon suffi cient request) (F, W, S)
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3.00 Credits
This is an advanced course in the principles of soil microbiology, groundwater microbiology, wastewater microbiology and composting microbiology. The class will also focus on practical applications of microorganisms isolated from various types of environments. Examples of commercial use of microorganisms will also be presented. The lab consists of a series of experiments looking at the microbial fl ora of soils and water. Students will also determine the biological oxygen demand of various water sources and sediment samples found in Western New York. (1001-404) Class 3, Lab 3, Credit 4 (F)
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3.00 Credits
This course is taken in the fi rst quarter of the Research Scholars Program. Students undertake long-term research projects under the mentorship of a faculty sponsor. Students must apply to the Research Scholars Program and be accepted prior to registration. Class variable, Credit variable 1-4 ( F, W, S, SU)
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