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Course Criteria
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3.00 Credits
Prerequisites: One year of introductory biology and at least one semester of additional biology courses, recommended: BIOL W3041 Cell Biology, BIOL C3512 Molecular Biology This is an advanced molecular and cellular biology course geared to upper level undergraduates and graduate students. The topic of this year will be cellular stress responses. We will read and analyze a series of reviews on this topic ranging from the stress of DNA damage on cells to metabolic stress to the stress of aging. We will also read key research articles on these topics. The signaling pathways, mechanisms, targets and biological relevance will be reviewed. An emphasis will be made on understanding how important discoveries were made. Students will develop their own review articles on related subjects and present multiple research proposals.
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3.00 Credits
Prerequisites: Four semesters of biology with a firm foundation in molecular and cellular biology. Introduces students to the current understanding of human diseases, novel therapeutic approaches and drug development process. Selected topics will be covered in order to give students a feeling of the field of biotechnology in health science. This course also aims to strengthen students' skills in literature comprehension and critical thinking. Website: http://www.columbia.edu/cu/biology/courses/w4300/
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4.00 Credits
The course will start with an introduction to types of biological networks and many of the new high throughput and quantitative technologies now available. We will start with the mathematical and computational analysis of small networks in order to understand some of the basic principles in biological networks including network motifs, modularity, robustness and stochasticity. The course will then scale up to much larger networks teaching the computation techniques needed to address these including Hidden Markov Models, Bayesian networks, FDR, Bootstrapping, Expectation Maximization, Inference, Gibbs Sampling, Monte Carlo and Belief Propagation. We cover many of the pitfalls of high throughput data and how to over come these, proper modeling choices when building large scale models of molecular networks and how to apply the techniques learned to real data. We will learn how to reconstruct regulatory networks from such data and understand how these networks compute, dynamically change and the connections between genetic sequence and these molecular regulatory networks. Finally will demonstrate how the Bayesian techniques learned in the course can be applied to other biological networks such as a network of interacting neurons.
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3.00 Credits
Biopharmaceutical Development & Regulation The program aims to provide current life sciences students with an understanding of what drives the regulatory strategies that surround the development decision making process, and how the regulatory professional may best contribute to the goals of product development and approval. To effect this we will examine operational, strategic and commercial aspects of the regulatory approval process for new drug, biologic and biotechnology products both in the United States and worldwide. The topics are designed to provide a chronological review of the requirements needed to obtain marketing approval. Regulatory strategic, operational, and marketing considerations will be addressed throughout the course. We will examine and analyze the regulatory process as a product candidates are advanced from Research and Development, through pre-clinical and clinical testing, to marketing approval, product launch and the post-marketing phase. The goal of this course is to introduce and familiarize students with the terminology, timelines and actual steps followed by Regulatory Affairs professionals employed in the pharmaceutical or biotechnology industry. Worked examples will be explored to illustrate complex topics and illustrate interpretation of regulations.
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3.00 Credits
Prerequisites: BIOT W4200 This course will provide a practical definition of the current role of the Regulatory Professional in pharmaceutical development, approval and post-approval actions. This will be illustrated by exploration, and interactive discussion of regulatory history, its evolution, current standards and associated processes. The course will seek to clarify the role of Regulatory in development and lifecycle opportunities, demonstrating the value Regulatory adds by participation on research, development and commercial teams. The course will utilize weekly case studies and guest lecturers to provide color to current topical events related to the areas.
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4.00 Credits
These courses introduce students to both the spoken and written Cantonese language, with achieving conversational proficiency being a primary goal. The courses emphasize oral expressions, listening comprehension and grammar. They are designed to give beginning students a practical command of the language. Upon completion of the course, students can expect to converse in simple sentences, and recognize and write about 350 Chinese characters. Students with passable conversation ability or native speakers from Cantonese-speaking communities should not enroll in these courses. These courses are part of the language exchange program with New York University (NYU). Classes will be held at NYU.
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4.00 Credits
These courses introduce students to both the spoken and written Cantonese language, with achieving conversational proficiency being a primary goal. The courses emphasize oral expressions, listening comprehension and grammar. They are designed to give beginning students a practical command of the language. Upon completion of the course, students can expect to converse in simple sentences, and recognize and write about 350 Chinese characters. Students with passable conversation ability or native speakers from Cantonese-speaking communities should not enroll in these courses. These courses are part of the language exchange program with New York University (NYU). Classes will be held at NYU.
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4.00 Credits
These courses further continue the study of the Cantonese language. Emphasis is on linguistic rules to enable students to communicate with more competence. The lessons will not only focus on language, but also incorporate discussions on history, current events, literature, popular culture, and native values. Includes field trips to Chinatown and other Cantonese-speaking neighborhoods. These courses are part of the language exchange program with New York University (NYU). Classes will be held at NYU.
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4.00 Credits
These courses further continue the study of the Cantonese language. Emphasis is on linguistic rules to enable students to communicate with more competence. The lessons will not only focus on language, but also incorporate discussions on history, current events, literature, popular culture, and native values. Includes field trips to Chinatown and other Cantonese-speaking neighborhoods. These courses are part of the language exchange program with New York University (NYU). Classes will be held at NYU.
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4.00 Credits
An extensive introduction to the Catalan language with an emphasis on oral communication as well as the reading and writing practice that will allow the student to function comfortably in a Catalan environment.
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