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  • BIOL W3040: Lab in Cell and Developmental Biology

    3.00 Credits
    Columbia University in the City of New York

    Prerequisites: 1 year of biology (C2005-C2006) This lab will explore various molecular biology techniques frequently utilized in modern molecular biology laboratories. The lab will consist of three modules: 1. PCR isolation, cloning and analysis of the GAPDH gene 2. Plasmid cloning 3. Yeast two hybrid. The maximum number of participants: 12. (Lab Fee: $150)
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  • BIOL W3041: Cell Biology

    3.00 Credits
    Columbia University in the City of New York

    Corequisites: Recommended preparation or corequisite: Biochemistry. Introduction to cell biology stressing the architecture of the cell as it relates to cellular function, physiology, biochemistry, and disease, as well as some detailed discussions of the experiments that have informed our current views of the cell.
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  • ShareBIOL W3058 - Project Laboratory in Microbiology
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  • BIOL W3073: Cellular and Molecular Immunology

    3.00 Credits
    Columbia University in the City of New York

    Prerequisites: Two semesters of a rigorous, molecularly-oriented introductory biology course (such as C2005 and C2006), or the instructor's permission. This course will cover the basic concepts underlying the mechanisms of innate and adaptive immunity, as well as key experimental methods currently used in the field. To keep it real, the course will include clinical correlates in such areas as infectious diseases, autoimmune diseases, cancer and transplantation. Taking this course won't turn you into an immunologist, but it may make you want to become one, as was the case for several students last year. After taking the course, you should be able to read the literature intelligently in this rapidly advancing field.
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  • BIOL W3190: Stem Cells: Biology, Ethics and Applications

    3.00 Credits
    Columbia University in the City of New York

    Prerequisites: Introductory Biology (BIOL W2005, W2006) plus one semester of Biology at the 3000 level or above; otherwise permission should be sought from the instructor (contact ddk1@columbia.edu). Dramatic advances in Stem Cell biology have created new possibilities for medical research and treatment. Realization of potential benefits requires continued scientific advances but also negotiation of the regulatory terrain and ethical considerations that determine what types of research and applications can and should be advanced. This course addresses the major breakthroughs and possibilities for both pluripotent stem cells (Embryonic Stem Cells and induced Pluripotent Stem Cells) and adult tissue-specific stem cells, including ethical and regulatory perspectives. Several classes will be predominantly lecture style while others will be largely discussion of ethics, medical applications or research papers. In addition the course features two public lectures concerning cutting edge stem cell research, an invited expert on regulatory affairs and a visit to the New York Stem Cell Foundation Laboratory. The course can be used as an elective for majors in Biology, Biochemistry, Biophysics or Neuroscience and Behavior.
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  • BIOL W3208: Introduction To Evolutionary Biology

    3.00 Credits
    Columbia University in the City of New York

    Recommended preparation: an introductory course in college biology. Introduction to principles of general evolutionary theory, both nomological and historical; causes and processes of evolution; phylogenetic evolution; species concept and speciation; adaptation and macroevolution; concepts of phylogeny and classification.
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  • BIOL W3310: Virology

    3.00 Credits
    Columbia University in the City of New York

    Prerequisites: Two semesters of a rigorous, molecularly-oriented introductory biology course (such as C2005), or the instructor's permission. The course will emphasize the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed.
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  • BIOL W3990: Readings in Cell Biology

    4.00 Credits
    Columbia University in the City of New York

    Prerequisites: Cell Biology (3041/4041) and the permission of the instructor. The class size is strictly limited to 24 students. This is an advanced cell biology course that uses detailed discussion of the primary literature to understand fundamental cellular processes. The focus is on dissecting research papers to gain insight into the rationale behind specific experimental approaches, understand how experiments are performed and critically analyze the data and interpretations. We will start with an introduction to critical thinking and experimental design and then probe four sequential papers from a prominent research lab that all investigate the same biological process. In this way, students gain an understanding of the creative nature of laboratory research and see how a research project develop and diversifies. Course requirements: Students must read assigned sections of each paper prior to class and be prepared to discuss the experimental approaches, outcomes and interpretations. Students will participate in group discussions, small group activities and must present findings to the class. Assessment will be based on periodic assignments, a midterm take-home exam, a final exam and a folio that students will maintain to track their own progress and document their findings. Participation in class discussions will also contribute to the final grade.
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  • BIOL W3995: Topics in Biology: Crossroads in Bioethics

    2.00 Credits
    Columbia University in the City of New York

    This course examines both the underlying scientific principles of biotechnologies and the ethical controversies brought about by recent advances in biology and medicine. This course is designed to engage students in difficult dialogues around the scientific, social, legal, and bioethical issues related to emerging areas of biotechnology and medicine. Topics include human stem cell research, human cloning, genetically modified organisms, reproductive medicine (IVF and pre-implantation genetic diagnosis), neuroethics, and the impact of genetics on medicine. This discussion-based course is designed is to provide students with a comprehensive understanding of the interrelationship between biomedical technologies and bioethics.
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  • BIOL W4070: The Biology and Physics of Single Molecules

    3.00 Credits
    Columbia University in the City of New York

    Prerequisites: calculus, chemistry, physics, 1 year biology, or instructors' permission This course will examine the fundamental mechanisms underlying the behavior of biological molecules, at the single molecule level. The course will cover the methods used to track single molecules: optical tweezers, single molecule AFM, Magnetic tweezers, Optical techniques and Fluorescence energy transfer (FRET) probes. The course will cover the mechanism of action of mechanical motors such as myosin dyneyin, kinesin. It will cover the action of DNA binding enzymes such as topoisomerases, helicases, etc. We will also discuss the function of large motors such as the ATP Synthase and the bacterial AAA ATPases. We will discuss the mechanical properties of DNA, RNA, and proteins. The course will consist mainly of reviewing classical experiments in each category, and developing the background physical theories to promote a deep understanding of biological mechanisms at the mesoscopic level.
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