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Course Criteria
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3.00 Credits
Introduction to principles and major applications of modern instrumental techniques, including electrochemical, spectrometric and chromatographic methods, as applied to materials assay, quantitative spectrometric analysis of organic compounds, and investigation of properties of materials and reactions. Laboratory component stresses operation of key instruments to obtain data typical of each. Prerequisites: Chemistry 331 and 333. Fall. Two 70-minute periods, two 3-hour laboratories. Langhus
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3.00 Credits
Physical methods for studying organic structures and reactions. Topics include Hückel molecular orbital theory; applications of the concept of conservation of orbital symmetry to cycloaddition, electrocyclic reactions, and sigmatropic rearrangements; kinetic isotope effects; linear free-energy relationships; trapping of reaction intermediates. Readings taken directly from chemical literature. Prerequisites: Chemistry 212 and 332. Fall. Three 50-minute periods, one 50-minute problem session. D. Libby
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3.00 Credits
Biochemistry of enzymes, coenzymes, and metabolic pathways from an organic chemist's point of view. Focus on molecular mechanisms of enzyme action and various ways enzymes are studied. Topics include relationships between protein structure and function, types of catalysis utilized by enzymes, detailed mechanisms of reaction steps of selected metabolic pathways including reactions involving coenzymes such as thiamine pyrophosphate (vitamin B1) and pyridoxal phosphate (vitamin B6) and methods used in study of enzyme reactions including kinetics, identifi cation of reaction intermediates, and chemical models for enzymatic reactions. Some examples will be taken from ongoing departmental research. Readings: text and standard biochemical reference books, as well as original biochemical literature. Prerequisite: Chemistry 212 or permission of instructor. Spring. Three 50-minute periods, one 50-minute problem session. D. Libby
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3.00 Credits
Introduction to retrosynthetic approach for designing syntheses of organic molecules and systematic investigation of synthetic use of organic reactions encountered in Chemistry 211-212. Course focus is on synthetic utility of various organic reactions and logic of synthetic design. Prerequisite: Chemistry 212 or permission of instructor. Fall. Three 50-minute periods, one 50-minute problem session. D. Libby
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3.00 Credits
Focus on the structural features of the four major classes of biomolecules and the basic functions of these molecules in cells. Coverage of the fundamentals of information fl ow in biological systems, enzyme kinetics and catalytic mechanisms will set the stage for Biology/Chemistry 328 (Biochemistry II). Students will also be introduced to many of the techniques used in biochemistry laboratories and begin to learn how to investigate biochemical problems. Prerequisites: Biology 265 and Chemistry 212 or permission of instructor. Fall. Three 50-minute lectures and one 3-hour laboratory. Sh. Dunham
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3.00 Credits
Builds upon the biochemical foundations covered in Biology/Chemistry 327. Areas include metabolic pathways, strategies and regulation, membrane transport, enzyme catalysis and regulation, bioenergetics, signal transduction pathways, and the biochemistry of disease. Students will be exposed to additional laboratory techniques, experimental design, bioinformatics, and grant proposal writing. Analysis of primary literature is an integral component of the course. Prerequisite: Biology/Chemistry 327 or permission of instructor. Spring. Three 50-minute lectures and one 3-hour laboratory. Husic
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3.00 Credits
States of matter, chemical thermodynamics, theory of solutions, chemical equilibria, electrochemistry, chemical kinetics, elementary quantum theory. Problems and laboratory reinforce theoretical discussion. Prerequisites: Chemistry 220.2 or 222, Mathematics 171, and Physics 112. Three 50-minute periods, one 50-minute problem session, one 3-hour laboratory. Writing-intensive. Salter
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3.00 Credits
Application of quantum mechanics to atomic and molecular structure, group theory, and atomic, molecular, and laser spectroscopy. Prerequisite: Chemistry 332. Fall. Three 50-minute periods and one 50-minute problem session. Salter
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3.00 Credits
Periodic-table relationships, bonding theories, coordination compounds, acid/base theories, organometallic compounds. Laboratory stresses synthesis and characterization of inorganic compounds. Prerequisite: Chemistry 331. Spring. Three 50-minute periods, one 3-hour laboratory. Martin
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3.00 Credits
Advanced topics in chemistry. Designed to provide senior-level students with the opportunity to deal with projects that bring together concepts from different areas of chemistry. Emphasis on development of ability for independent analysis of chemical problems. Includes lectures by visiting speakers on current chemical research, as well as literature research, written reports, and oral presentations on a chemical topic chosen by student in consultation with a faculty advisor. In addition, students will critique presentations by visiting scientists and other students. Prerequisite: Senior status or permission of department chair. Spring. One 100-minute period. Salter
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