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  • Biology 353: Apoptosis:A Matter of Life and Death

    3.00 Credits
    Haverford College

    NA J.Punt Cell death is as important to an organism as cell differentiation and proliferation. In order to shape organs, limbs, and digits, form neural pathways, build a useful repertoire of specificities in the immune system, and start and stop inflammatory reactions, an organism needs to be able to regulate cell death via a highly regulated process we call apoptosis. A lack of regulation between cell death and proliferation underlies many disease states, including cancer and AIDS. In this course we will explore current advances in our understanding of the molecular basis for cell death (apoptosis), its regulation, its relationship to cell differentiation and proliferation, and its role in disease processes. The material will be presented in seminar format where primary literature will be read extensively and students will take the lead in the discussion and debate of current controversies. Enrollment limited to 15 students. Prerequisite: Biology 200 and 300b or consent of instructor.
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  • Biology 354: Computational Genomics

    3.00 Credits
    Haverford College

    NA P.Meneely Complete or nearly complete DNA sequences are available for the genomes of hundreds of species, inclining humans. Computer-based comparisons between DNA sequences of two different genes or two different species are now routinely used in biological research. This course will examine the biological and evolutionary basis of sequence comparisons, as well as introduce the students to the statistical foundations for such comparisons. The format will involve both lectures and in-class work done at the computer. Potential topics include: evolution of DNA sequences; sequence comparisons; alignment of sequences; identification of domains or motifs within proteins; gene structure identification in a DNA sequence; and large scale genome comparisons. Enrollment limited to 15 students. Prerequisite: Biology 301 or consent of instructor; Biology 303 recommended; student should be comfortable with statistical reasoning and high school algebra.
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  • Biology 355: Signal Transduction and Cell Biology

    3.00 Credits
    Haverford College

    NA J. Punt This seminar course covers major areas of current interest in the field of cell signaling biochemistry and biology. Topics include: cell surface receptor structure and function; heterotrimeric G proteins and oncogenesis. Provides present-day thinking on dysregulation of signaling pathways and how this leads to the development of various types of cancers. Enrollment limited to 15 students. Prerequisite: Biology 200 and 300b or consent of instructor.
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  • Biology 357: Protein Design

    3.00 Credits
    Haverford College

    NA R.Fairman This course will take a quantitative approach to the study of protein folding and protein structure using the primary research literature. We will particularly focus on these issues as they relate to function. Topics will include protein: DNA interactions, protein: protein interactions, and chaperones and their role in protein folding. Enrollment limited to 15 students. Prerequisite: Biology 200 and 300b or consent of instructor.
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  • Biology 358: Developmental Genetics

    3.00 Credits
    Haverford College

    NA R.Hoang This course will examine the structure of sex chromosomes, and how differences in sex chromosome constitution give rise to the morphological differences between males and females. The emphasis will be on the genetic and molecular basis of sex determination, using the primary research literature. Model organisms will include invertebrates such as Caenorhabditis elegans and Drosophila melanogaster and vertebrates such as placental and non-placental mammals and reptiles. Prerequisite: Biology 301 or consent of instructor.
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  • Biology 359: Molecular Oncology

    3.00 Credits
    Haverford College

    NA K.Grugan This seminar will be a discussion of current concepts and literature on the molecular and cellular basis of cancer. To the physician, cancer is a broad spectrum of dozens of different diseases. On the molecular level, by contrast, the outlines of a unifying genetic explanation for neoplasia are becoming clear. The seminar will explore the basis for this genetic paradigm of cancer and what it portends for future management of the disease. Topics will include: the mechanism of neoplastic transformation; the role of proto-oncogenes in normal and cancer cells; the tumor suppressor genes; the molecular and genetic pathogenesis of cancer; molecular genetics in diagnosis and treatment of cancer. Enrollment limited to 15 students. Prerequisite: Biology 300 or consent of the instructor.
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  • Biology 360: Bacterial Pathogenesis

    3.00 Credits
    Haverford College

    NA I.Okeke The course will begin with lectures to overview current concepts in bacterial pathogenesis. Initial readings will be taken from texts or reviews on the subject, and the rest of the course will consist of focused discussions on current research in the field and student presentations on the primary literature. Enrollment limited to 15 students. Prerequisite: Biology 200 and 300b or consent of instructor.
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  • Biology 363: Stem Cell Biology

    3.00 Credits
    Haverford College

    NA S.Emerson This course will develop an understanding of the molecular mechanisms that regulate stem cell self-renewal and differentiation. These issues will be examined by exploring the primary literature on topics such as hematopoietic (bone marrow) stem cells and their use as therapeutic agents. Enrollment limited to 15 students. Prerequisite: Bio300b or consent of the instructor
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  • Biology 402: Senior Research Tutorial in Genetics and Meiosis

    3.00 Credits
    Haverford College

    NA P.Meneely The principles and mechanisms by which the chromosome number is reduced and segregated during the production of gametes are studied in the nematode Caenorhabditis elegans. Genetic, molecular, and microscopic methods are used to isolate and examine mutant strains which fail to execute meiosis properly. Laboratory work is supplemented by readings from the current literature on meiosis and C. elegans. Prerequisite: Consent of instructor.
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  • Biology 403: Senior Research Tutorial in Protein Folding and Design

    3.00 Credits
    Haverford College

    NA R.Fairman The laboratory focuses on protein folding and design, with a particular emphasis on the use of proteins in nanoscience. Students will have the opportunity to apply chemical and genetic approaches to the synthesis of proteins for folding and design studies. Such proteins are characterized in the laboratory using biophysical methods (such as circular dichroism spectroscopy, analytical ultracentrifugation, and atomic force microscopy). Functional and structural approaches can also be applied as necessary to answer specific questions relating to protein science. Laboratory work is supplemented with readings in the original literature. Prerequisite: Consent of the instructor.
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