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  • CHEM 6170: Advanced Topics in Nuclear Magnetic Resonance

    4.00 Credits
    Rensselaer Polytechnic Institute

    Advanced graduate course covering fundamental aspects of NMR common for application in a broad range of fields. Classical and quantum-mechanical descriptions are utilized to explore information content of NMR pulse sequences. The latter approach includes density matrix theory and proceeds with the product-operator formalism. Practical aspects and data analysis are also described. Subsequent focus is on liquid-state NMR of biological macromolecules, including resonance assignment and determination of molecular structure and dynamics. (Students cannot obtain credit for both this course and BCBP 6170.) Prerequisites/Corequisites: Prerequisite: CHEM 4410 or equivalent. When Offered: Spring term annually. Credit Hours: 4
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  • CHEM 6190: Molecular Spectroscopy

    3.00 Credits
    Rensselaer Polytechnic Institute

    Introduction of interaction of light with molecules; theory of molecular energies and applications to rotational, vibrational, and electronic spectroscopy. Prerequisites/Corequisites: Prerequisites: CHEM 4410 and CHEM 4420 or permission of instructor. When Offered: Fall term odd-numbered years. Credit Hours: 3
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  • CHEM 6210: Advanced Organic Chemistry I

    3.00 Credits
    Rensselaer Polytechnic Institute

    An introduction to the organic chemical literature. A consideration of reactions of synthetic importance to the organic chemist with emphasis on the influence of structure on the behavior of organic molecules. When Offered: A fall-spring sequence annually. Credit Hours: 3
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  • CHEM 6220: Advanced Organic Chemistry II

    3.00 Credits
    Rensselaer Polytechnic Institute

    An introduction to the organic chemical literature. A consideration of reactions of synthetic importance to the organic chemist with emphasis on the influence of structure on the behavior of organic molecules. When Offered: A fall-spring sequence annually. Credit Hours: 3
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  • CHEM 6280: Natural Products Chemistry

    3.00 Credits
    Rensselaer Polytechnic Institute

    A survey of modern synthetic methods used in construction of the major groups of secondary metabolites and related natural products. The essentials of retrosynthetic analysis are presented and instruction in the development of strategies for organic synthesis are offered. Prerequisites/Corequisites: Prerequisites: CHEM 6210 and CHEM 6220. When Offered: Fall term odd-numbered years. Credit Hours: 3
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  • CHEM 6300: Medicinal Chemistry

    3.00 Credits
    Rensselaer Polytechnic Institute

    The organic chemistry of drug discovery and synthesis will be the focus of this course. Starting with the basic concepts of molecular-targeted drug discovery, the process of lead identification will be explored with special emphasis on drug screening and combinatorial chemistry. The roles of computational chemistry, molecular modeling, and biophysical methods in the understanding of the relationship between structure and biological activity will be studied. The chirality of drugs from both the biological and synthetic perspectives will also be explored. Prerequisites/Corequisites: Prerequisite: CHEM 6210 or permission of instructor. Credit Hours: 3
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  • CHEM 6310: Bioorganic Mechanisms

    3.00 Credits
    Rensselaer Polytechnic Institute

    The study of mechanisms of organic reactions in biochemical processes on a molecular level. Enzyme active sites, mechanisms of enzymatic transformations, catalysis, cofactors, enzyme kinetics, environmental toxicology. Strong emphasis on the design and mechanism of action of pharmaceutical agents. Meets with CHEM 4310; both courses cannot be taken for credit. Prerequisites/Corequisites: Prerequisite: permission of instructor. When Offered: Spring term odd-numbered years. Credit Hours: 3
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  • CHEM 6330: Drug Discovery

    3.00 Credits
    Rensselaer Polytechnic Institute

    This course will examine how bioinformatics, functional genomics and other modern biotechnologies are used to speed the discovery of new drugs, especially those small organic molecules to treat human diseases with large unmet therapeutic need. Special emphasis will be placed on molecular target identification and validation as well as high-throughput screening to identify a lead. Topics to be discussed will include transgenic mice, RNA interference, DNA and protein microarrays, homogenous time-resolved fluorescence bioassays, phage-display, combinatorial chemistry and parallel synthesis. Students cannot receive credit for both this course and CHEM 4330. Prerequisites/Corequisites: Prerequisite: A knowledge of organic chemistry is required. Credit Hours: 3
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  • CHEM 6450: Nonlinear Laser Spectroscopy

    3.00 Credits
    Rensselaer Polytechnic Institute

    An introduction to the theory and practice of multiphoton or nonlinear laser spectroscopic and nonlinear optical phenomena. Emphasis is placed on the spectroscopic applications of nonlinear optical phenomena such as harmonic generation, sum and difference frequency generation, stimulated Raman scattering, multiphoton absorption and ionization, and four-wave mixing methods such as coherent anti-Stokes Raman scattering. There are no prerequisites, but a background in molecular spectroscopy is recommended. When Offered: Spring term odd-numbered years. Credit Hours: 3
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  • CHEM 6480: Chemical Kinetics

    3.00 Credits
    Rensselaer Polytechnic Institute

    Kinetics of thermochemical and photochemical reactions. Mathematical and mechanistic descriptions of the phenomenological approach to rate process; theoretical treatments of kinetically simple reactions; principles of light absorption and photochemistry; organic photochemistry. Prerequisites/Corequisites: Prerequisite: permission When Offered: of instructor. Spring term odd-numbered years. Credit Hours: 3
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