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Course Criteria
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2.00 Credits
Laboratory exploration including synthesis and characterization of several types of inorganic compounds, with emphasis on the use of physical methods in inorganic chemistry. Communication of results in written and oral form is an integral part of the course. This is a communication-intensive course. Prerequisites/Corequisites: Corequisites: CHEM 4010 and CHEM 4410. When Offered: Fall term annually. Credit Hours: 2
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2.00 Credits
This course will introduce advanced instrumental physicochemical methods of chemical analysis and will include such topics as separations (chromatography), atomic spectroscopy, molecular spectroscopy, and electroanalytical chemistry. Non-majors, particularly those in Biochemistry and Engineering (Biomedical, Environmental, etc. except Chemical Engineering) are encouraged to take this course. Chemistry majors should register for CHEM 4120 concurrently. Prerequisites/Corequisites: Prerequisites: CHEM 2110 and CHEM 2120 or permission of the instructor. When Offered: Fall term annually. Credit Hours: 2
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2.00 Credits
A laboratory course emphasizing the hands-on use of modern instrumental methods in analytical and physical chemistry applications, and the interpretation and discussion of the results obtained from them. This is a communication-intensive course. Prerequisites/Corequisites: Experiments depend on the theoretical material in CHEM 4110 and CHEM 4420, which are corequisites. When Offered: Spring semester. Credit Hours: 2
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3.00 Credits
A lecture-laboratory course that begins by establishing a knowledge base in the fundamental physical principles of NMR and then provides an understanding of basic and some advanced NMR experiments. This understanding extends to the actual performance of many of these experiements in the laboratory portion of the course. The use of NMR as a powerful tool to solvechemical problems will be explored. Topics included will be: Relaxation, Coupling and NOE, Multinuclear NMR, Spectral Editing, Multidimensional NMR, Solid State NMR, and the special challenges of Macromolecular NMR. Enrollment limited to advanced undergraduates. Prerequisites/Corequisites: Prerequisite: permission of instructor. When Offered: Spring even numbered years. Cross Listed: Students cannot get credit for both this course and CHEM 6160. Credit Hours: 3
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4.00 Credits
Modern methods used in analysis of environmental samples for monitoring and research purposes. Standard and advanced techniques of air, water, sediment, and soil analysis are covered including spectrometric and chromatographic methods. Prerequisites/Corequisites: Prerequisite: permission of the instructor required. When Offered: Fall term odd-numbered years. Cross Listed: (Cross-listed as ERTH 4190. Students cannot obtain credit for both this course and ERTH 4190.) Credit Hours: 4
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4.00 Credits
Organic and medicinal chemistry play a crucial role in the discovery of agents used to treat human disease. The basis of this course is the study of the drug discovery process from the perspective of these chemical disciplines. Concepts to be studied are molecular targeted drug discovery, lead compound identification and optimization, biophysical and molecular modeling tools, biological barriers to drug action and ways chemistry can overcome them, and the biotech industry. Topics pertinent to drug development such as drug metabolism and clinical research will also be discussed. Prerequisites/Corequisites: Prerequisite: CHEM 2220 or CHEM 2260 or permission of instructor. Credit Hours: 4
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4.00 Credits
The study of mechanisms of organic reactions in biochemical processes on a molecular level. Enzyme active sites, mechanisms of enzymatic transformations, catalysis, cofactors, enzyme kinetics, environmental toxicology. Strong emphasis on the design and mechanism of action of pharmaceutical agents. Meets with CHEM-6310; both courses cannot be taken for credit. Prerequisites/Corequisites: Prerequisite: CHEM 2220 or CHEM 2260 or permission of instructor. When Offered: Fall term. Credit Hours: 4
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3.00 Credits
This course will examine how bioinformatics, functional genomics and other modern biotechnologies are used to speed the discovery of new drugs, especially those small organic molecules to treat human diseases with large unmet therapeutic need. Special emphasis will be placed on molecular target identification and validation as well as high-throughput screening to identify a lead. Topics to be discussed will include transgenic mice, RNA interference, DNA and protein microarrays, homogenous time-resolved fluorescence bioassays, phage-display, combinatorial chemistry and parallel synthesis. Students cannot receive credit for both this course and CHEM 6330. Prerequisites/Corequisites: Prerequisite: CHEM 2220 or CHEM 2260 or permission of instructor. When Offered: Fall term annually. Credit Hours: 3
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1.00 Credits
In this laboratory associated with CHEM-4330, students will reduce to practice the chemical and biological aspects of high-throughput screening used to discover lead molecules. Colorimetric and fluorescence plate readers will be used in 96-well plate format to generate enzyme inhibition data for small libraries of organic molecules. Students will use these inhibition data and published X-ray structural data to develop a pharmacophore model and rationalize a structure-activity relationship. Prerequisites/Corequisites: Prerequisite: CHEM 4330 or concurrent with CHEM 4330. When Offered: Fall term annually. Credit Hours: 1
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4.00 Credits
A course dealing with physicochemical properties of substances on a macroscopic scale. Chemical thermodynamics, electrochemistry, electric and magnetic phenomena, transport properties and surface and colloid chemistry When Offered: Fall term annually. Credit Hours: 4
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