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Course Criteria
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0.00 - 4.00 Credits
This seminar style course will focus on the basic science that provides the background for understanding diseases caused by defects in chromosome maintenance. Readings will be in the primary literature, and classroom participation will be a key part of the course. Topics will include telomeres, trinucleotide repeats, DNA damage check points, tumor susceptibility genes, and chromatin modification.
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0.00 - 4.00 Credits
In this course, we will explore the diverse and complex interactions between the brain and the immune system from the perspective of current, cutting-edge research papers. In particular, we will focus on the molecular mechanisms of these interactions and their role in brain development and function as well as their potential contributions to specific neurological disorders, including autism. In the process, students will learn to read, critically evaluate, and explain in presentations the content of articles from the primary literature.
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0.00 - 4.00 Credits
The chemistry and structure of mononucleotides, oligonucleotides, and polynucleotides and their helical complexes are presented as a basis for understanding and predicting the structures and structure-function relations of naturally occurring DNAs and RNAs. Functions to be considered include fidelity of DNA replication and transcription, mutagenic mechanisms, molecular evolution, roles and mechanisims of action of recently discovered small RNAs, and nature and organization of the genetic code.
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0.00 - 4.00 Credits
A discussion of the field of Bioinformatics, the application of computing to research in Molecular Biology. Topics include: nucleic acid and protein sequence analysis, secondary structure prediction, microarray analysis, sequence homology, the protein folding problem, molecular computers, Perl programming, and the use of the genetic databases.
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0.00 - 4.00 Credits
The application of current tools of human genetics and genomic analysis including SNPs, copy number variants, HapMaps, high throughput DNA sequencing and DNA microarrays to perform genome-wide association studies of complex traits with an emphasis on neurological diseases including autism and schizophrenia. Recent evolution within the human species and genetic divergence of human populations in response to selective forces. Extensive use will be made of online genome databases as interactive tools for genome analysis.
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0.00 - 4.00 Credits
This course will highlight the various contributions of mass spectrometry-based proteomics to various life science fields. Areas covered will include fundamentals of mass spectrometry, protein identification and quantification, characterization of post-translational modifications and protein interactions. This course will include discussions on the present state of proteomic research, with special emphasis on characterizing protein assemblies and applications to virology, signal transduction pathways and epigenetic networks.
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0.00 - 4.00 Credits
This course focuses on the molecules and molecular assemblies that underlie cellular structure and function. Topics will include protein structure and folding; ligand binding and enzyme catalysis; membranes, ion channels, and translocation; intracellular trafficking; signal transduction and cell-cell communication; and cytoskeleton assembly, regulation, and function. A major goal of the course is to increase proficiency in parsing and critically discussing papers from the primary literature.
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0.00 - 4.00 Credits
Advanced-level discussions of the genetics and molecular biology of prokaryotic organisms and their associated bacteriophages. Emphasis is placed on original research papers, and extensive reading is required. Topics include the genetic code, mutagenesis, mechanisms of DNA replication, recombination, repair and transposition, gene structure and function and mechanisms of gene regulation, protein synthesis and export.
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0.00 - 4.00 Credits
Discussion of gene structure and organization, chromatin and chromosome structures, mechanisms of replication, gene expression and regulation in eukaryotic cells. Emphasis will be placed on unique features of eukaryotic systems with examples from higher and lower eukaryotes.
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0.00 - 4.00 Credits
Selected topics in the cell biology and development of multicellular organisms, with an emphasis on basic principles and underlying molecular mechanisms. Topics include gradients and pattern formation during embryogenesis, receptors and intracellular signaling, cell motility and cell movements, neuronal pathfinding and patterning in the vertebrate neural tube, redundancy and genomic redundancy. Classes center on critical reading of the primary literature.
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