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Course Criteria
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0.00 - 4.00 Credits
Central concepts and experiments in cellular, molecular, and developmental biology with an emphasis on underlying physical and engineering principles. Topics include important insights into the genetic code; energetics and cellular organization; communication, feeding, and signaling between cells; ideas about feedback loops and cellular organization; problems and solutions in development; and the organization of large cellular systems, such as the nervous and immune systems. Satisfies the requirement for entrance into the Department and the requirement for entrance into medical school.
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0.00 - 4.00 Credits
Medical research aims to improve and maintain human health. Accordingly, researchers employ such strategies as understanding biology, defining disease mechanisms, and developing ways to prevent, treat, or cure. Today, the U.S. is the preeminent global power in medical research through interactions among government, academia, and industry. This course will trace the evolution of this country's research enterprise, describe its diverse cultures, focus on its greatest achievements (and achievers), and identify a number of challenges confronting it currently. How the U.S. copes with these challenges will influence the future of world health.
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0.00 - 4.00 Credits
A broad survey of the field of immunology and the mammalian immune system. The cellular and molecular basis of innate and acquired immunity will be discussed in detail. The course will provide frequent exemplars drawn from human biology in health and disease.
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0.00 - 4.00 Credits
Basic principles of genetics illustrated with examples from prokaryote and eukaryote organisms with emphasis on classic genetic techniques. The evolving conception of the gene and genome will be the primary focus of the course. Selected advanced topics will include Drosophila developmental genetics, yeast cell biology and human disease.
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0.00 - 4.00 Credits
Fundamental concepts of biomolecular structure and function will be discussed, with an emphasis on principles of thermodynamics, binding and catalysis. A major portion of the course will focus on metabolism and its logic and regulation.
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0.00 - 4.00 Credits
The mechanisms that underlie development of multicellular organisms, from C. elegans to humans, will be examined using biochemical, genetic and cell biological approaches. The course will investigate the roles that gene regulation, cell-cell communication, cell adhesion, cell motility, cell death, signal transduction and intracellular trafficking play in the commitment, differentiation and assembly of cells into specialized tissues.
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0.00 - 4.00 Credits
The major objective of the course is to introduce students to a variety of tools required to conduct independent research in the field of molecular biology. While completing original research, students will employ a number of techniques that are used by molecular biologists, molecular geneticists, and biochemists. Upon completion of the course, students should have gained an understanding of how, when and why certain techniques and skills are used in a research setting. In addition, students will learn to write a research report modeled on the scientific literature.
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0.00 - 4.00 Credits
This course will examine fundamental determinants of human microbe interaction at the biological and ecological aspects. The focus will be on major global infectious diseases, their burden of illness, and policy challenges for adequate prevention and control. Each infectious agent will be discussed in terms of its mechanism of pathogenesis, disease progression, epidemiology, as well as strategies for its control. Specific emphasis will be placed on the public health aspects of each disease.
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0.00 - 4.00 Credits
Accurate control of cell cycle is essential for the formation and maintenance of a normal living organism. This course will study the molecular machinery that controls the cell cycle and the devastating consequence of its de-regulation that leads to cancer. We begin with a mechanistic examination of the cell cycle in bacteria, yeast, flies and mammals. We then consider cell cycle and cell size, and the cell cycle of stem cells. We will also discuss the oncogenic events that disrupt the normal cell cycle, the signaling pathways that activate uncontrolled cell proliferation, and the molecular therapeutics that target oncogenic pathways.
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0.00 - 4.00 Credits
The course will cover contemporary approaches to the study of neural development, emphasizing genetic and molecular techniques. Topics include generation, patterning, differentiation, and survival of neurons and their progenitors, axon growth and guidance, target selection, synapse formation/elimination, activity-dependent remodeling of connectivity, and the relationship between neural development and behavior. Reading will be mainly from the primary literature with textbook reading provided for background. Student participation during discussions in class is required.
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