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Course Criteria
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3.00 Credits
Advanced physics and applications of magnetic resonance imaging and spectroscopy will be covered. Upon completion of this course, the student will understand the factors that affect the MRI signal, and will know how these factors can be exploited to image or measure various aspects of physiology with MR. Prerequisites: BME 8782 Magnetic Resonance Imaing and MATLAB experience.
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3.00 Credits
Biomechanics and structural biology of cell structure and function, focusing on quantitative description and measurements of cell deformability, adhesion, and locomotion. Cell deformability: erythrocyte properties, membrane mechanics, shear, bending, and area elasticity. Leukocyte structure and deformability. Structural basis of plasma membrane, lipid bilayer, surface structures, nucleus, organelles, cell junctions, cytoskeleton, membrane transport, active cytoskeletal functions, specific and non-specific forces between molecules, protein structure, molecular graphics. Cell adhesion molecules: families of adhesion molecules, cell-cell and cell-matrix binding, biochemical characteristics, regulation of expression, regulation of binding avidity, functional role. Cell adhesion assays: detachment assays, aggregation of leukocytes and platelets, controlled shear systems, flow chambers. Mechanics of cell adhesion: equilibrium analysis of cell adhesion, models of cell rolling, adhesion bond mechanics. Liposomes, microbubbles, and applications to targeted adhesion. Cell motility: measurement of active forces and motility in cells, molecular motors. Effects of mechanical stress and strain on cell function.
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3.00 Credits
In this class, students design treatment strategies for cancer and cardiovascular disease based on molecular bioengineering principles. Special topics will include design of nanoparticle drug and gene delivery platforms, materials biocompatibility, cancer immunotherapy, and molecular imaging. Prerequisites: Undergraduate coursework in cell and molecular biology and biomechanics. Recommended undergraduate course in transport processes.
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1.00 - 12.00 Credits
For master’s students.
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1.00 - 6.00 Credits
A research project in biomedical engineering conducted in consultation with a faculty advisor. Includes the design, execution, and analysis of experimental laboratory work and computational or theoretical computer analysis of a problem. Fulfills the project requirement for the Biomedical Engineering Masters of Engineering degree.
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1.00 - 12.00 Credits
Master’s Research
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1.00 - 12.00 Credits
For doctoral students.
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1.00 - 12.00 Credits
Formal record of student commitment to doctoral research under the guidance of a faculty advisor. May be repeated as necessary.
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3.00 Credits
Introduces students to the essentials of Bulgarian grammar with emphasis on speaking and reading.
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3.00 Credits
Introduces students to the essentials of Bulgarian grammar with emphasis on speaking and reading.
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