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Course Criteria
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3.00 Credits
Biology of cancer will be discussed at the molecular, cellular and organismic level. Emphasis will be placed on cellular signaling, apostosis and cell cycle unique to cancer cells, which affects tumor cell behavior and its interactions with the host immune system. The biology of hematopoitic cells will also be included. Clinicians active in treatment and research of various types of cancer will be invited to participate in the lectures. Prereq: BCH 501, 502, BIO 685. (Same as MED/MI 616.)
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2.00 Credits
The study of function by global analysis of gene expression. Teaches the concepts, techniques, and functional significance of analyzing gene expression patterns. The technical emphasis is on the design and analysis of DNA microarray experiments. Examples of normal function or disease states in which gene expression profiling has had a significant impact are also taught. Prereq: IBS 604 and IBS 602 or equivalents. (Same as PGY 617.)
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3.00 Credits
The objective of this course is to familiarize graduate students with the principles and mechanisms of drug action in biochemical and physiological systems. Students will discuss the quantitative approaches to assessing drug responses, metabolism and toxicity. Prereq: Consent of instructor.
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1.00 - 4.00 Credits
PHA 622 is an advanced course designed to provide graduate students with state of the art information regarding drugs, drug action and targets for drug action. Emphasis will be placed on drugs that interact with the cardiovascular system (section 001), the central nervous system (section 002), chemotherapeutic agents (section 003), and other important drug classes such as nonsteroidal anti-inflammatory agents, steroid hormones, antidiabetic agents and toxicology (section 004). Each section is designed to be a separate one hour course. Students may take any combination of sections from one to all four sections. For each agent, emphasis will be placed on the cellular mechanisms of action, the receptors or cellular targets at which they act, therapeutic issues and potential toxicities. This information is intended to be integrated with other disciplines, including anatomy, biochemistry, physiology, psychology and molecular biology. Prereq: IBS 601-609 and PHA 621.
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1.00 - 3.00 Credits
Detailed examination of current, significant topics in pharmacology such as: contemporary neuroscience methodology, molecular and cellular pharmacodynamics, transmembrane signaling. Course is designed to offer flexibility to students in different tracks, different emphasis in a given year and to utilize the special research interests in resident and visiting investigators. May be repeated to a maximum of six credits. Prereq: Consent of course director.
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2.00 Credits
A discussion of the mechanism of action, dosing theory, toxicity and metabolism of drugs used as therapeutic agents in the treatment of cardiovascular disease. Prereq: Consent of instructor.
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2.00 Credits
This course will provide in-depth coverage of the molecular pharmacology of growth factors, transcription factors, receptors, and ion channels. Emphasis will be placed on both the normal functions of these cell-signaling molecules and perturbations that result in several prevalent human diseases, including cancer, Alzheimer's, diabetes, osteoporosis, and inherited human illnesses. Students will be introduced to experimental approaches to diagnosing and treating these illnesses in the light of our evolving knowledge of molecular pharmacology. Prereq: IBS 601-606 or consent of instructor. (Same as PHR/TOX 649.)
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2.00 Credits
A study of the general theories of the mode of action of drugs upon nervous tissue and a review of the effects of analgesics, sedatives, hypnotics, anesthetics, tranquilizers, psychotomimetics, analeptics, antidepressants, anti-convulsants and drugs affecting motor dyskinesias upon neurones, synapses and functional components of the central nervous system. Prereq: PHA 522, IBS 601-606, or consent of instructor.
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3.00 Credits
Lectures and discussion of the chemical and biochemical reactions of chemical carcinogens and their metabolites. Prereq: CHE 232; PHR 400; or BCH 501, 502. (Same as TOX 670.)
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3.00 Credits
This course will examine the alterations in the brain that occur with aging and in neurodegenerative disorders such as Alzheimer's disease. The emphasis will be on human aging although the relevance of animal models to studies of human aging will be a recurrent theme. The course will examine aging at several levels, including molecular, cellular, organismic, and behavioral. Prereq: GRN 620. A strong background in the basic sciences. (Same as ANA/GRN/PGY 710.)
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