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Course Criteria
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1.00 Credits
Immunology associated with fertilization, implantation, and early development in humans. Various procedures for detecting antibodies associated with reproduction will be discussed and the laboratories will assess both direction and indirect antibodies on spermatozoa. Prereq: BIO 494G, CSC 620, CSC 621.
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1.00 Credits
Principles of cryopreservation will be covered; includes sessions on cryopreservation of human sperm and mouse embryos. Legal, ethical and policy issues associated with cryopreservation will be introduced. Prereq: CSC 620 and CSC 621.
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2.00 Credits
Current and anticipated regulations of assisted reproductive technology will be discussed. Legal and ethical concerns associated with ART will be introduced and case studies will focus on specific issues. Prereq: CSC 620, 621, 624.
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2.00 Credits
Students must complete the checklist procedures while working under supervision. Andrology procedures will include semen analysis, sperm function tests, microbiology, preparation for artificial insemination, and cryopreservation of male gametes. Prereq: CSC 620, 621, 623, 624, 625.
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3.00 Credits
Students must complete the checklist procedures while working under supervision. All ART procedures including in vitro fertilization, ICSI, zona hatching and cryopreservation of gametes and embryos will be practiced under supervision using appropriate models for practice. Prereq: CSC 620, 621, 623, 624, 625.
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1.00 - 5.00 Credits
Research projects for students in Reproductive Laboratory Science. Students will complete web-based modules, "The Scientific Method and the Art of Research" prior to project initiation. Projects should be related to the student's individual interest and should address an area in reproductive laboratory science. Projects should be under the supervision of a faculty member with expertise in the project area. Prereq: CSC 528, CSC 615, CSC 616, and CSC 617 or consent of instructor. Additional CSC courses in the RLS track may be required as prerequisites depending on the nature of the research project.
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3.00 Credits
In-depth study of the human histocompatibility polymorphisms will include genetic inheritance, alleles, typing methodologies, and matching requirements for solid organ and tissue transplantation. The human leukocyte antigen (HLA or MHC) system and its role in transplant rejection will be the major focus, however minor histocompatibility systems will also be examined. Specific and detailed correlation of didactic information will be integrated with case studies to explore current concepts of immunologically-based molecular methods of antigen detection and their impact on clinical practice. Prereq: Immunology course.
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3.00 Credits
Human immunology with an emphasis on experimental methods, signal transduction, cell-cell interactions, cytokine production and activity, cell marker expression during normal cell development, pathogenic expression of cell markers and their detection, immunotherapy, vaccine production and acquired immunity. Analysis of immunologic systems mediating the response to allogenic foreign molecules such as transplanted tissues and organs will be emphasized. Contemporary issues and trends in immunology, with an emphasis on malignancy and immunodeficiencies, will be examined. Prereq: Immunology course.
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3.00 Credits
Course content includes immunological, biochemical and genetic concepts and molecular biology related to the clinical process of transplantation. Cellular and molecular mechanisms will be an intense focus of this course. Solid organ and tissues transplantation, the need for donor organs and tissues, compatibility requirements for successful transplantation of each type of organ and tissue, immunosuppressive therapy, and research opportunities that may impact successful transplantation and tissue availability will be examined. Literature review and presentation of papers on assigned topics will be required. Prereq: CSC 670 or consent of instructor.
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3.00 Credits
This course focuses on principles, applications and quality assurance of flow cytometry in research and clinical use in hematology and transplantation. Emphasis is placed on the biological and physical principles underlying flow cytometry, specimen processing, operation and specific application in the identification of various hematopoietic and other cells. The use of flow cytometry to screen transplant recipients, cross-match donor and potential recipient, post-transplant monitoring, identifying HLA antigens, diagnosing hemoproliferative disorders, monitoring immunosuppressive therapy and stem cell isolation is presented. Evolving applications in other disciplines such as microbiology and clinical chemistry, will also be explored. Prereq: CSC 670, or CSC 674 and CSC 675, or consent of instructor.
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