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Course Criteria
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4.00 Credits
Case studies on the effect of genetic engineering on medicine, agriculture, biology, forensics, and various other areas of technology. Each week a set of assigned readings will be discussed. Some of the topics to be covered are vaccines, biomolecular computing and electronics, paleontology, ecology, bioremediation, and polymers. (Students cannot obtain credit for both this course and BCBP 6310.) Prerequisites/Corequisites: Prerequisites or corequisites: BCBP 4760 and BIOL 4620, or permission of instructor. When Offered: Fall term, odd-numbered years. Credit Hours: 4
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4.00 Credits
Characterization of patterns and changes in patterns of protein expression with development, aging, and disease. Protein separation and quantification strategies; mass spectrometry and analysis of spectra; protein profiling, biomarkers, post-translational modifications; current applications; emerging technologies and applications. Individual presentations on relevant topics will be expected. (Students cannot obtain credit for this course and BIOL 4640, BCBP 6640 or BIOL 6640.) Prerequisites/Corequisites: Prerequisite: BCBP 4760 or equivalent. When Offered: Spring term annually. Credit Hours: 4
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4.00 Credits
Major principles of biochemistry are illustrated as students purify and analyze specific proteins. Experience is obtained with various techniques including tissue extraction, chromatography, ultracentrifugation, spectrophotometric analysis, and electrophoresis. The course includes extensive hands-on laboratory work, as well as the writing of in-depth reports, and is a writing-intensive course. (Students cannot obtain credit for both this course and BIOL 4710.) This is a communication- intensive course. Prerequisites/Corequisites: Prerequisite: BIOL 1010. When Offered: Spring term annually. Credit Hours: 4
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3.00 Credits
Part I of a two-semester sequence focusing on the chemistry, structure, and function of biological molecules, macromolecules, and systems. Topics covered include protein and nucleic acid structure, enzymology, mechanisms of catalysis, regulation, lipids and membranes, carbohydrates, bioenergetics, and carbohydrate metabolism. This course is taught in studio mode. (Students cannot obtain credit for both this course and either BIOL 4760 or CHEM 4760.) Prerequisites/Corequisites: Prerequisites: CHEM 2250 or CHEM 2210 and BIOL 1010 or equivalent. When Offered: Fall term annually. Cross Listed: Cross listed as BIOL 4760 and CHEM 4760 Credit Hours: 4
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4.00 Credits
The second semester of the molecular biochemistry sequence. Topics include lipids and lipid metabolism, amino acid metabolism and the coenzymes involved in this metabolism, nucleic acid synthesis and chemistry, protein synthesis and degradation, integration of metabolism, photobiology, and photosynthesis. This course is taught in studio mode. (Students cannot obtain credit for both this course and either BIOL 4770 or CHEM 4770.) Prerequisites/Corequisites: Prerequisite: BCBP 4760 or equivalent. When Offered: Spring term annually. Cross Listed: Cross listed as BIOL 4770 and CHEM 4770. Credit Hours: 4
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4.00 Credits
The biophysical mechanism of protein folding and the role of misfolding in human diseases is explored. The course will introduce principles of protein structure, protein folding in the cell, and thermodynamic and kinetic methods for studying protein folding in vitro. The course will also involve a literature-based discussion of human diseases related to protein folding defects, including Alzheimer's and other amyloid diseases, cystic fibrosis, and Prion-related syndromes. Spring term even-numbered years. Prerequisites/Corequisites: Prerequisite: BCBP 4760 or equivalent. (Students may not receive credit for both this course and BCBP 6780, CHEM 4780, or CHEM 6780.) Credit Hours: 4
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4.00 Credits
Explores the use of spectroscopic methods to study biological systems. Theory and application of techniques including UV-visible absorbance spectroscopy, IR spectroscopy, fluorescence, electron paramagnetic resonance and nuclear magnetic resonance, and their application to the study of the structure of macromolecules, enzyme mechanism, and other important biological problems covered. (Students cannot obtain credit for both this course and BCBP 6810.) Prerequisites/Corequisites: Prerequisite: BCBP 4760 or equivalent. When Offered: Fall term even-numbered years. Credit Hours: 4
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4.00 Credits
X-ray crystallography and nuclear magnetic resonance (NMR) are used to determine 3-D structures of biological macromolecules at atomic resolution. The course will cover crystallographic and NMR methods, their theory and practice, along with thermodynamics of structure formation and molecular dynamics. Students will prepare a poster presentation on a protein of their choice. (Students cannot obtain credit for both this course and BCBP 6870.) Prerequisites/Corequisites: Prerequisites: BCBP 4760, MATH 1020, and PHYS 1200 or equivalents. When Offered: Fall term even numbered years. Credit Hours: 4
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4.00 Credits
Independent laboratory research, on or off campus, supervised by a faculty member, culminating in a written thesis; or literature research culminating in the writing of a review article. The thesis research must also be presented in the form of a poster presentation or a talk. This is a communication-intensive course. Prerequisites/Corequisites: Prerequisite: permission of instructor. When Offered: Offered each term. Credit Hours: 4
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4.00 Credits
Advanced graduate course covering fundamental aspects of NMR common for application in a broad range of fields. Classical and quantum-mechanical descriptions are utilized to explore information content of NMR pulse sequences. The latter approach includes density matrix theory and proceeds with the product-operator formalism. Practical aspects and data analysis are also described. Subsequent focus is on liquid-state NMR of biological macromolecules, including resonance assignment and determination of molecular structure and dynamics. (Students cannot obtain credit for both this course and CHEM 6170.) Prerequisites/Corequisites: Prerequisite: CHEM 4410 or equivalent. When Offered: Spring term annually. Credit Hours: 4
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