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  • EN 580.223: Models & Simulations

    4.00 Credits
    Johns Hopkins University

    Prereq: 110.201(Linear Algebra), 110.302 (Differential equations) or 550.291 (Linear Algebra and Differential Equations) This course introduces students to modeling and analysis of biological systems. The first portion of the course focuses on linear systems. Topics include harmonic oscillators, pharmacokinetics, reaction-diffusion equation, heat transfer, and fluid flow. The second half of the course focuses on non-linear systems. Topics include iterated maps, bifurcations, chaos, stability of autonomous systems, the Hodgkin-Huxley model, bistability, limit cycles, and the Poincare-Bendixson theorem. The course also introduces students to the Matlab programming language, which allows them to implement the models discussed in class.
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  • ShareEN 580.302 - Careers in Biomed Eng.
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  • EN 580.312: BME Design Group

    3.00 Credits
    Johns Hopkins University

    A two semester course sequence where juniors and seniors work with a team leader and a group of BME freshmen and sophomores, to solve open-ended problems in biomedical engineering. Upperclassmen are expected to apply their general knowledge and experience, and their knowledge in their concentration area, to teach lower classmen and to generate the solution to practical problems encountered in biomedical engineering.
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  • ShareEN 580.412 - BME Design Group
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  • ShareEN 580.414 - Design Team/Team Leader
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  • EN 580.420: Build-a-Genome

    4.00 Credits
    Johns Hopkins University

    Prereq: Must understand fundamentals of DNA structure, DNA electrophoresis and analysis, Polymerase Chain Reaction (PCR) and must be either a) Experienced with molecular biology lab work or b) Adept at programming with a biological twist. In this combination lecture/laboratory "Synthetic Biology" course students will learn how to make DNA building blocks used in an international project to build the world's first synthetic eukaryotic genome, Saccharomyces cerevisiae v. 2.0. Please study the wiki www.syntheticyeast.org for more details about the project. Following a biotechnology boot-camp, students will have 24/7 access to computational and wet-lab resources and will be expected to spend 15-20 hours per week on this course. Advanced students will be expected to contribute to the computational and biotech infrastructure.
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  • EN 580.422: Systems Bioengineering II

    4.00 Credits
    Johns Hopkins University

    Prereq: 580.221 (Molecules and Cells), 580.222 (Systems and Controls), 580.223 (Models and Simulations), 110.302 (Differential Equations), 580.421 (Physiological Foundations I). Coreq: 580.424 (Physiological Foundations Laboratory II). A quantitative, model-oriented approach to the study of the nervous system. Topics include functional anatomy of the central and autonomic nervous systems, neurons and networks, learning and memory, structure and function of the auditory and visual systems, motor systems, and neuro-engineering.
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  • EN 580.424: Systems Bioengineering Lab

    2.00 Credits
    Johns Hopkins University

    Coreq: 580.422 A laboratory course in which various physiological preparations are used as examples of problems of applying technology in biological systems. The emphasis in this course is on the design of experimental measurements and on physical models of biological systems.
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  • EN 580.425: Ion Channels in Excitable Membranes

    3.00 Credits
    Johns Hopkins University

    Prereqs: 580.421 and 580.422 or equivalent. Recommended: 110.201, 110.302, signals and elementary probability. Ion channels are key signaling molecules that support electrical communication throughout the body. As such, these channels are a central focus of biomedical engineering as it relates to neuroscience, computational biology, biophysics, and drug discovery. The course introduces the engineering and molecular strategies used to understand the function of ionic channels. The course also surveys key papers that paint the current picture of how ion channels open and conduct ions. Biological implications of these properties are emphasized throughout. Finally, the course introduces how optical and electrophysiological methods now promise to revolutionize understanding of ionic channels. This course can be seen as a valuable partner of Models of the Neuron (580.439).
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  • EN 580.442: Tissue Engineering

    3.00 Credits
    Johns Hopkins University

    Prereqs: 580.221 or 020.305 and 020.306, 030.205. Recommended 580.441/580.641. This course focuses on the application of engineering fundamentals to designing biological tissue substitutes. Concepts of tissue development, structure and function will be introduced. Students will learn to recognize the majority of histological tissue structures in the body and understand the basic building blocks of the tissue and clinical need for replacement. The engineering components required to develop tissue-engineered grafts will be explored including biomechanics and transport phenomena along with the use of biomaterials and bioreactors to regulate the cellular microenvironment. Emphasis will be placed on different sources of stem cells and their applications to tissue engineering. Clinical and regulatory perspectives will be discussed. Co-listed with 580.642
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