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BIOL 4355: Molecular Biology of Neurological and Hematological Diseases
3.00 Credits
The University of Texas at Dallas
Neurological and hematological diseases affect millions of Americans each year, often fatally. The course will bring students up to date on current knowledge of the molecular biology of neurological diseases such as Alzheimer's, Parkinson's, Amyotropic lateral sclerosis andHuntington's disease. Hematological diseases such as hemolytic anemias including sickle cell disease and thalassemia, platelet disorders and clinical case studies will be covered, along with efforts towards gene therapy. The course comprises lectures, student presentations, and presentations by world experts in the field. Prerequisites: BIOL 3301, BIOL 3302, and BIOL/CHEM 3361 or their equivalents, or the written consent of the instructor. (3-0) T
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BIOL 4365: Advanced Human Physiology
3.00 Credits
The University of Texas at Dallas
Function and integration of human organ systems. The role of these systems in the adaptation of humans to, and their interaction with, the environment. Maintenance and perturbation of homeostasis. Pathophysiological basis of certain diseases. Prerequisite: BIOL 3302 or consent of instructor. (3-0) T
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BIOL 4366: Molecular Biology of Cancer
3.00 Credits
The University of Texas at Dallas
Subject matter includes a discussion of representative examples of the principal categories of dominantly acting oncogenes. The role in oncogenesis of tumor suppressor genes ("recessive oncogenes") is also considered, as are anti-apoptotic oncogenes such as Bcl. The roles that the proteins encoded by these genes play in growth hormone signal transduction, gene regulation, cell cycle regulation, and programmed cell death will be examined. Students will also read and discuss the primary literature in this field. Prerequisite: BIOL 3302. (3-0) T
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BIOL 4370: Developmental Neurobiology
3.00 Credits
The University of Texas at Dallas
Examines some of the remarkable progress made in recent years towards understanding how the nervous system develops. Among topics covered are signals regulating formation of neural tissue, patterning of the brain, differentiation and migration of neurons, formation of neural connections, neuronal survival, and elimination of superfluous cells. Course is designed to be interactive and will include lectures, student presentations, and discussion of important discoveries in the area. Prerequisites: BIOL 2311 and BIOL 3301. (3-0) T
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BIOL 4375: Bioinformatics
3.00 Credits
The University of Texas at Dallas
A practical approach to quantitative and statistical analysis of biological sequence and structural information. Classroom lectures are accompanied by practical demonstrations and computer lab exercises. Topics include genomic information content, data searches and sequence alignment, mutations and distance-based phylogenetic analysis, genomics and gene recognition, polymorphisms and forensic applications, nucleic-acid and protein array analysis, and structure prediction of biological macromolecules. Pre-requisites: BIOL 3301, BIOL 3361 and two semesters of calculus. Suggested additional preparation: one semester introductory statistics. (3-0) T
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BIOL 4380: Cell and Molecular Biology Laboratory
3.00 Credits
The University of Texas at Dallas
Current techniques that are utilized in a modern Molecular Biology research laboratory. Practical skills taught include monitoring bacterial growth, phenotype testing, plasmid isolation, restriction digest analysis, DNA cloning, and DNA fingerprinting using the polymerase chain reaction (PCR). Advanced techniques include fundamental microscopy, DNA transfection and general characterization of animal cell cultures, sub-cellular fractionation using differential centrifugation, basic immunological techniques, and chemical mutagen testing. Prerequisite: BIOL 3380. Pre- or co-requisite: BIOL 3302. (1-2) S
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BIOL 4382: Advanced Molecular Biology Laboratory
3.00 Credits
The University of Texas at Dallas
Advanced techniques for the study of biological systems: spectroscopy, ultracentrifugation, radioactive labeling, and construction and screening of cDNA expression libraries. Prerequisites: BIOL 3301, BIOL 3302, and BIOL/CHEM 3361 or their equivalents, or the written consent of the instructor. (1-2) Y
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BIOL 4390: Senior Readings in Molecular and Cell Biology
3.00 Credits
The University of Texas at Dallas
For students conducting independent literature research and scientific writing in Biology or Molecular and Cell Biology. Subject and scope to be determined on an individual basis. Satisfies the Advanced Writing Requirement for Biology and Molecular Biology majors. Topics may vary. Prerequisite: Consent of instructor. (3-0) S
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BIOL 4391: Senior Research in Molecular and Cell Biology
3.00 Credits
The University of Texas at Dallas
For students conducting laboratory research and scientific writing in Biology or Molecular and Cell Biology. Subject and scope to be determined on an individual basis. Satisfies the Advanced Writing Requirement for Biology and Molecular Biology majors. Topics may vary. Prerequisite: Consent of instructor. (3-0) S
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BIOL 4398: Senior Honors Readings in Molecular and Cell Biology
3.00 Credits
The University of Texas at Dallas
For students conducting independent literature research for honors in Biology or Molecular and Cell Biology. Besides the university specifications the student should contact the undergraduate advisor in biology for program requirements. Satisfies the Advanced Writing Requirement for Biology and Molecular Biology majors. Topics may vary. Prerequisite: Consent of instructor. (3-0) S
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