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Course Criteria
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0.00 Credits
Non-credit laboratory to accompany BIOE 8280. Coreq: BIOE 8280.
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3.00 Credits
Interventional electrophysiology procedures, including baseline interval measurements, pulse stimulator control for diagnostic information, conduction system and refractory periods assessment. Supraventricular and ventricular tachyarrhythmias assessment, post-pacing and pacing protocols; radiofrequency ablation and complications; radiofrequency generator and irrigated tip ablation systems and transseptal punctures. Preq: BIOE 8260 and BIOE 8270, or consent of instructor. Coreq: BIOE 8291.
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0.00 Credits
Non-credit laboratory to accompany BIOE 8290. Coreq: BIOE 8290.
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2.00 Credits
Methods of imaging utilized during electrophysiologic procedures. Three-dimensional CT images of the heart editing; echocardiographic planer images for three-dimensional cardiac chambers; standard radiographic imaging techniques, including rotational angiography; 3-D electroanatomic maps for arrhythmia assessment and ablative treatment. Preq or concurrent enrollment: BIOE 8290; or consent of instructor.
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2.00 Credits
Electrophysiologic procedures and methods to treat atrial fibrillation and ventricular tachycardia; recording, imaging, mapping and ablative methods; and setup and maintenance of robotic mapping and ablation. Preq: BIOE 8280 and BIOE 8290; or consent of instructor.
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2.00 Credits
Trouble shooting of electrical noise, grounding problems, fractured cables, insulation breaks, computer and imaging errors. Covers treatment of complications from procedures such as respiratory failure, cardiac tamponade, cardiac arrest, stroke, loss of pacing capture, use of transcutaneous pacing, external defibrillation, inappropriate shocks, placement of pericardial drains, chest tubes, and hematoma expansion. Preq or concurrent enrollment: BIOE 8310; or consent of instructor.
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3.00 Credits
Comprehensive principles of drug design, development and delivery in the context of creating biomaterial-based prodrugs and applying pharmaceutical therapies in tissue engineering/regenerative medicine. The relationship between drug physico-chemical properties and pharmacokinetics/pharmacodynamics and drug delivery systems to improve therapeutic efficiency and reduce toxicity through targeting and controlled release is covered. Students are expected to have completed undergraduate courses in organic chemistry and cell biology before enrolling in this course.
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3.00 Credits
Form and function of human organs, major systems and examples of engineering repair and replacement methods are presented in light of pathological or traumatic organ malfunction.
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4.00 Credits
Mathematical modeling of blood flow through capillaries and solute transfer from capillaries to tissues by diffusion and convection, pharmacokinetic analysis of drug adsorption, transport and elimination routes in body, and analysis of the design and performance of extracorporeal devices for organ replacement, including hemodialysis, blood oxygenation and immobilized enzyme reactors. Students are expected to have completed coursework in undergraduate-level engineering math, including calculus through differential equations, before enrolling in this course.
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4.00 Credits
Cell biological concepts and issues relevant to cell-biomaterial interactions; methods for studying cell structure and function including basic cell culture techniques and in vitro biocompatibility analyses; biomaterial physio-chemical properties which influence cellular interactions; interactions between implant materials and host tissues at the cellular and molecular level; overview of tissue engineering. Coreq: BIOE 8481.
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