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  • CBB 252: Structure of Biological Macromolecules

    3.00 Credits
    Duke University

    Computer graphics intensive study of some of the biological macromolecules whose three-dimensional structures have been determined at high resolution. Emphasis on the patterns and determinants of protein structure. Two-hour discussion session each week along with computer-based lessons and projects. Instructors: D. Richardson and J. Richardson
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  • CBB 258: Structural Biochemistry I

    2.00 Credits
    Duke University

    Principles of modern structural biology. Protein-nucleic acid recognition, enzymatic reactions, viruses, immunoglobulins, signal transduction, and structure-based drug design described in terms of the atomic properties of biological macromolecules. Discussion of methods of structure determination with particular emphasis on macromolecular X-ray crystallography NMR methods, homology modeling, and bioinformatics. Students use molecular graphics tutorials and Internet databases to view and analyze structures. Prerequisites: organic chemistry and introductory biochemistry. Instructors: Beese and staff
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  • CBB 259: Structural Biochemistry II

    2.00 Credits
    Duke University

    Continuation of Biochemistry 258. Structure/function analysis of proteins as enzymes, multiple ligand binding, protein folding and stability, allostery, protein-protein interactions. Prerequisites: Biochemistry 258, organic chemistry, physical chemistry, and introductory biochemistry. Instructors: Hellinga and staff
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  • CBB 261: Computational Sequence Biology

    3.00 Credits
    Duke University

    Introduction to algorithmic and computational issues in analysis of biological sequences: DNA, RNA, and protein. Emphasizes probabilistic approaches and machine learning methods, e.g. Hidden Markov models. Explores applications in genome sequence assembly, protein and DNA homology detection, gene and promoter finding, motif identification, models of regulatory regions, comparative genomics and phylogenetics, RNA structure prediction, post-transcriptional regulation. Prerequisites: basic knowledge algorithmic design (Computer Science 230 or equivalent), probability and statistics (Statistics 213 or equivalent), molecular biology (Biology 118 or equivalent). Alternatively, consent instructor. Instructor: Hartemink or Ohler
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  • CBB 262: Computational Systems Biology

    3.00 Credits
    Duke University

    Provides a systematic introduction to algorithmic and computational issues present in the analysis of biological systems. Emphasizes probabilistic approaches and machine learning methods. Explores modeling basic biological processes (e.g., transcription, splicing, localization and transport, translation, replication, cell cycle, protein complexes, evolution) from a systems biology perspective. Lectures and discussions of primary literature. Prerequisites: basic knowledge of algorithm design (Computer Science 230 or equivalent), probability and statistics (Statistics 213 or equivalent), molecular biology (Biology 118 or equivalent), and computer programming. Alternatively, consent of instructor. Instructor: Hartemink or Ohler
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  • CBB 263: Algorithms in Structural Biology and Biophysics

    3.00 Credits
    Duke University

    Introduction to algorithmic and computational issues in structural molecular biology and molecular biophysics. Emphasizes geometric algorithms, provable approximation algorithms, computational biophysics, molecular interactions, computational structural biology, proteomics, rational drug design, and protein design. Explores computational methods for discovering new pharmaceuticals, NMR and X-ray data, and protein-ligand docking. Prerequisites: basic knowledge of algorithm design (Computer Science 230 or equivalent), probability and statistics (Statistics 213 or equivalent), molecular biology (Biology 118 or equivalent), and computer programming. Alternatively, consent of instructor. Instructor: Donald
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  • CBB 264: Computational Geometry

    3.00 Credits
    Duke University

    Models of computation and lower-bound techniques; storing and manipulating orthogonal objects; orthogonal and simplex range searching, convex hulls, planar point location, proximity problems, arrangements, linear programming and parametric search technique, probabilistic and incremental algorithms. Prerequisite: Computer Science 230 or equivalent. Instructor: Agarwal or Edelsbrunner
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  • CBB 265: Data-Intensive Computing Systems

    3.00 Credits
    Duke University

    Data-Intensive Computing Systems. Principles and techniques for making intelligent use of the massive amounts of data being generated in commerce, industry, science, and society. Topics include indexing, query processing, and optimization in large databases, data mining and warehousing, new abstractions and algorithms for parallel and distributed data processing, fault-tolerant and self-tuning data management for cloud computing, and information retrieval and extraction for the Web. Prerequisites: Computer Science 116 or an introductory database course or consent of instructor. Instructor: Babu or J. Yang
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  • CBB 300: Internship

    1.00 Credits
    Duke University

    Student gains practical experience by taking an intership in industry, and writes a report about this experience. Requires prior consent from the studetnt's advisor and from the Director of Graduate Studies. May be repeated with consent of the advisor and the Director of Graduate Studies. Credit/no credit grading only. Instructor: Staff
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  • CCS 150: Children in Contemporary Society

    1.00 Credits
    Duke University

    Major developmental stages of childhood and influences in a child's life: parents/family life, schools, communities, the economy Emphasis on 1) applying of theory for analyzing complex societal problems (often involving issues of race, class, and gender; 2) using material and methodologies from psychology, sociology, economics, and public policy. Required course for certificate program Children in Contemporary Society, but open to all undergraduate students
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