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  • BME 242L: Introduction to Bionanotechnology Engineering

    3.00 Credits
    Duke University

    A general overview of nanoscale science/physical concepts will be presented as those concepts tie in with current nanoscience and nanomedicine research. Students will be introduced to the principle that physical scale impacts innate material properties and modulates how a material interacts with its environment. Important concepts such as surface-to-volume ratio, friction, electronic/optical properties, self-assembly (biological and chemical) will be contextually revisited. A number of laboratory modules ("NanoLabs") will guide students through specific aspects of nanomedicine, nanomaterials, and engineering design. Prerequisites: BME 83L and BME 100L or consent of instructor
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  • BME 246: Computational Methods in Biomedical Engineering (GE)

    3.00 Credits
    Duke University

    Introduction to practical computational methods for data analysis and simulation with a major emphasis on implementation. Methods include numerical integration and differentiation, extrapolation, interpolation, splining FFTs, convolution, ODEs, and simple one- and two-dimensional PDEs using finite differencing. Introduction to concepts for optimizing codes on a CRAY-YMP. Examples from biomechanics, electrophysiology, and imaging. Project work included and students must have good working knowledge of Unix, Fortran, or C. Intended for graduate students and seniors who plan on attending graduate school. Prerequisite: Engineering 53L or equivalent, Mathematics 107 or equivalent, or consent of instructor. Instructor: Henriquez
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  • BME 247: Drug Delivery (GE, BB, MC)

    3.00 Credits
    Duke University

    Introduction to drug delivery in solid tumors and normal organs (for example, reproductive organs, kidney, skin, eyes). Emphasis on quantitative analysis of drug transport. Specific topics include: physiologically-based pharmacokinetic analysis, microcirculation, network analysis of oxygen transport, transvascular transport, interstitial transport, transport across cell membrane, specific issues in the delivery of cells and genes, drug delivery systems, and targeted drug delivery. Prerequisite: Biomedical Engineering 207 and Engineering 53. Instructor: Yuan
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  • BME 248: Tissue Engineering (GE, MC)

    3.00 Credits
    Duke University

    This course will serve as an overview of selected topics and problems in the emerging field of tissue engineering. General topics include cell sourcing and maintenance of differentiated state, culture scaffolds, cell-biomaterials interactions, bioreactor design, and surgical implantation considerations. Specific tissue types to be reviewed include cartilage, skin equivalents, blood vessels, myocardium and heart valves, and bioartificial livers. Prerequisites: Mathmetics 108 or consent of instructor. Instructor: Bursac
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  • BME 252: Neural Signal Acquisition (GE, IM, EL)

    3.00 Credits
    Duke University

    This course will be an exploration of analog and digital signal processing techniques for measuring and characterizing neural signals. the analog portion will cover electrodes, amplifiers, filters and A/D converters for recording neural electrograms and EEGs. The digital portion will cover methods of EEG processing including spike detection and spike sorting. A course pack of relevant literature will be used in lieu of a textbook. Students will be required to write signal-processing algorithms. Prerequisite: Biomedical Engineering 154L. Instructor: Wolf
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  • BME 253: Computational Neuroengineering (GE, EL)

    3.00 Credits
    Duke University

    This course introduces students to the fundamentals of computational modeling of neurons and neuronal circuits and the decoding of information from populations of spike trains. Topics include: integrate and fire neurons, Spike Response Models, Homogeneous and Inhomogeneous Poisson processes, neural circuits, Weiner (optimal), Adaptive Filters, neural networks for classification, population vector coding and decoding. Programming assignments and projects will be carried out using MATLAB. Prerequisites: BME 101/201 or equivalent. Instructor: Henriquez
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  • BME 254: Fundamentals of Electrical Stimulation of the Nervous System (GE, EL)

    3.00 Credits
    Duke University

    This course presents a quantitative approach to the fundamental principles, mechanisms, and techniques of electrical stimulation required for non-damaging and effective application of electrical stimulation. Consent of instructor required. Instructor: Grill
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  • BME 256: Neural Prosthetic Systems

    3.00 Credits
    Duke University

    This course will cover several systems that use electrical stimulation or recording of the nervous system to restore function following disease or injury. For each system the course will cover the underlying biophysical basis for the treatment,the technology underlying the treatment,and the associated clinical applications and challenges. Systems to be covered include cochlear implants, spinal cord stimulation of pain, vagus nerve stim. for epilepsy, deep brain stim. for movement disorders, sacral root stim. for bladder dysfunction, and neuromuscular electrical stim.for restoration of movement. Prerequisites: Biomedical Engineering 101L, Biomedical Engineering 153L, and consent of instructor. Instructor: Grill
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  • BME 258L: Genome Science & Technology Lab (GE, MC)

    1.00 - 3.00 Credits
    Duke University

    Hands-on experience on using and developing advanced technology platforms for genomics and proteomics research. Experiments may include nucleic acid amplification and quantification, lab-on-chip, bimolecular separation and detection, DNA sequencing, SNP genotyping, microarrays, and synthetic biology techniques. Laboratory exercises and designing projects are combined with lectures and literature reviews. Prior knowledge in molecular biology and biochemistry is required. Instructor consent required. Instructor: Tian
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  • BME 260L: Devices for People with Disabilities (DR or GE, IM, BB)

    3.00 Credits
    Duke University

    Design of custom devices to aid disabled individuals. Students will be paired with health care professionals at local hospitals who will supervise the development of projects for specific clients. Formal engineering design principles will be emphasized; overview of assistive technologies, patent issues, engineering ethics. Oral and written reports will be required. Selected projects may be continued as independent study. Prerequisite: Biomedical Engineering 154L and Statistics 113. Instructor: Bohs or Goldberg
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