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  • BME 231: Intermediate Biomechanics (GE, BB)

    3.00 Credits
    Duke University

    Introduction to solid and orthopaedic biomechanical analyses of complex tissues and structures. Topics to be covered include: spine biomechanics, elastic modeling of bone, linear and quasi-linear viscoelastic properties of soft tissue (for example, tendon and ligament), and active tissue responses (for example, muscle). Emphasis will be placed on experimental techniques used to evaluate these tissues. Student seminars on topics in applied biomechanics will be included. Prerequisites: Biomedical Engineering 110L or Engineering 75L; Mathematics 108. Instructor: Myers or Setton
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  • BME 233: Modern Diagnostic Imaging Systems (AC or GE)

    3.00 Credits
    Duke University

    The underlying concepts and instrumentation of several modern medical imaging modalities. Review of applicable linear systems theory and relevant principles of physics. Modalities studied include X-ray radiography (conventional film-screen imaging and modern electronic imaging), computerized tomography (including the theory of reconstruction), and nuclear magnetic resonance imaging. Prerequisite: Biomedical Engineering 171, junior or senior standing. Consent of instructor required. Instructor: Smith or Trahey
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  • BME 233A: Modern Medical Diagnostic Imaging Systems

    3.00 Credits
    Duke University

    This course covers the mathematics, physics, and instrumentation of several modern medical imaging modalities starting with a review of applicable linear systems theory and relevant principles of physics. Modalities studied include X-ray photography (film-screen and electronic), computerized tomography, ultrasound and nuclear magnetic resonance imaging. Consent of instructor required. Instructor: MacFall
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  • BME 234: Modern Microscopy (GE, IM)

    3.00 Credits
    Duke University

    Overview of novel microscopy techniques that are under development in research laboratories. New techniques are placed in context with basic understanding of image formation in conventional microscopy and laboratory work which applies this knowledge. A group project offers opportunity to examine special topics of interest. Prerequisite: Biomedical Engineering 154 or graduate standing. Instructor: Wax
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  • BME 235: Acoustics and Hearing (GE, IM)

    3.00 Credits
    Duke University

    The generation and propagation of acoustic (vibrational) waves and their reception and interpretation by the auditory system. Topics under the heading of generation and propagation include free and forced vibrations of discrete and continuous systems, resonance and damping, and the wave equation and solutions. So that students may understand the reception and interpretation of sound, the anatomy and physiology of the mammalian auditory system are presented; and the mechanics of the middle and inner ears are studied. Prerequisites: Biomedical Engineering 171 or equivalent and Mathematics 107. Instructor: Collins or Trahey
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  • BME 236L: Biophotonic Instrumentation (DR or GE, IM)

    3.00 Credits
    Duke University

    Theory and laboratory practice in optics, and in the design of optical instruments for biomedical applications. Section I focuses on basic optics theory and laboratory practice. Section II focuses on deeper understanding of selected biophotonic instruments, including laboratory work. Section III comprises the design component of the course. In this part, student teams are presented with a design challenge, and work through the steps of engineering design culminating in building a prototype solution to the design challenge. Lecture topics include engineering design, intellectual property protection, engineering ethics, and safety. Prerequisites: Biomedical Engineering 154L and Statistics 113. Instructor: Izatt or Wax
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  • BME 237: Biosensors (GE, IM, MC)

    3.00 Credits
    Duke University

    Biosensors are defined as the use of biospecific recognition mechanisms in the detection of analyte concentration. The basic principles of protein binding with specific reference to enzyme-substrate, lectin-sugar, antibody-antigen, and receptor-transmitting binding. Simple surface diffusion and absorption physics at surfaces with particular attention paid to surface binding phenomena. Optical, electrochemical, gravimetric, and thermal transduction mechanisms which form the basis of the sensor design. Prerequisites: Biomedical Engineering 83L and 100L or their equivalent and consent of instructor. Instructor: Reichert or Vo-Dinh
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  • BME 238: Advanced Optics

    3.00 Credits
    Duke University

    This course presents a rigorous treatment of topics in Photonics and Optics targeted at students with an existing photonics or optics background. Topics will include, Optical Sources, Statistical Optics and Coherence Theory, Detection of Radiation; Nonlinear Optics; Waveguides and Optical Fibers; Modern Optical Modulators; Ultrafast lasers and Applications. These topics will be considered individually and then from a system level perspective. Prerequisite: ECE 122 or equivalent. Instructor: Gauthier
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  • BME 239: Cell Transport Mechanisms (GE, MC)

    3.00 Credits
    Duke University

    Analysis of the migration of cells through aqueous media. Focus on hydrodynamic analysis of the directed self-propulsion of individual cells, use of random walk concepts to model the nondirected propulsion of individual cells, and development of kinetic theories of the migrations of populations of cells. Physical and chemical characteristics of the cells' environments that influence their motion, including rheologic properties and the presence of chemotactic, stimulatory, or inhibitory factors. Cell systems include mammalian sperm migration through the female reproductive tract, protozoa, and bacteria. Emphasis on mathematical theory. Experimental designs and results. Prerequisites: Biomedical Engineering 207 and consent of instructor. Instructor: Katz
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  • BME 240L: Environmental Molecular Biotechnology (GE, MC)

    3.00 Credits
    Duke University

    Principles of genetics and recombinant DNA for environmental systems. Applications to include genetic engineering for bioremediation, DGGE, FISH, micro-arrays and biosensors. Laboratory exercises to include DNA isolation, amplification, manipulation and analysis. Prerequisites: CE 124L/BIO 25 or consent of the instructor. Instructor: Gunsch
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