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  • BME 216: Transport Phenomena in Cells and Organs (GE, MC)

    3.00 Credits
    Duke University

    Applications of the principles of mass and momentum transport to the analysis of selected processes of biomedical and biotechnological interest. Emphasis on the development and critical analysis of models of the particular transport process. Topics include: reaction-diffusion processes, transport in natural and artificial membranes, dynamics of blood flow, pharmacokinetics, receptor-mediated processes and macromolecular transport, normal and neoplastic tissue. Prerequisite: Biomedical Engineering 207 or equivalent. Instructor: Truskey or Yuan
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  • BME 217: Cell Mechanics and Mechanotransduction

    3.00 Credits
    Duke University

    This course examines the mechanical properties of cells and forces exerted by cells in biological processes of clinical and technological importance and the processes by which mechanical forces are converted into biochemical signals and activate gene expression. Topics covered include measurement of mechanical properties of cells, cytoskeleton mechanics, models of cell mechanical properties, cell adhesion, effects of physical forces on cell function, and mechanotransduction. Students will critically evaluate current literature and analyze models of cell mechanics and mechanotransduction. Prerequisites: Engineering 75 and Biomedical Engineering 207 or equivalent, knowledge of cell biology and instructoor consent. Instructror: Truskey
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  • BME 218: Biotechnology and Bioprocess Engineering (GE, BB, MC)

    3.00 Credits
    Duke University

    Introduction to the engineering principles of bioprocess engineering. Topics include: introduction to cellular and protein structure and function; modeling of enzyme kinetics, DNA transcription, metabolic pathways, cell and microbial growth and product formation; bioprocess operation, scale-up, and design. Class includes a design project. A modern biotechnology process or product is identified, the specific application and market are described (for example, medical, environmental, agricultural) along with the engineering elements of the technology. Prerequisite: Biomedical Engineering 83L or Mechanical Engineering 83L. Instructor: Chilkoti or Reichert
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  • BME 220L: Introduction to Biomolecular Engineering (GE, BB, MC)

    3.00 Credits
    Duke University

    Structure of biological macromolecules, recombinant DNA techniques, principles of and techniques to study protein structure-function. Discussion of biomolecular design and engineering from the research literature. Linked laboratory assignments to alter protein structure at the genetic level. Expression, purification, and ligand-binding studies of protein function. Consent of instructor required. Instructor: Chilkoti
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  • BME 221: Modeling and Engineering Gene Circuits

    3.00 Credits
    Duke University

    This course discusses modeling and engineering gene circuits, such as prokaryotic gene expression, cell signaling dynamics, cell-cell communication, pattern formation, stochastic dynamics in cellular networks and its control by feedback or feedforward regulation, and cellular information processing. The theme is the application of modeling to explore "design principles" of cellular networks, and strategies to engineer such networks. Students need to define an appropriate modeling project. At the end of the course, they're required to write up their results and interpretation in a research-paper style report and give an oral presentation. Prerequisites: Biomedical Engineering 100L or consent of instructor. Instructor: You
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  • BME 222: Principles of Ultrasound Imaging (GE, IM)

    3.00 Credits
    Duke University

    Propagation, reflection, refraction, and diffraction of acoustic waves in biologic media. Topics include geometric optics, physical optics, attenuation, and image quality parameters such as signal-to-noise ratio, dynamic range, and resolution. Emphasis is placed on the design and analysis of medical ultrasound imaging systems. Prerequisites: Mathematics 107 and Physics 62L. Instructor: von Ramm
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  • BME 222L: Ultrasound Imaging

    3.00 Credits
    Duke University

    No course description available.
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  • BME 227L: Design in Biotechnology (DR or GE, MC, BB)

    3.00 Credits
    Duke University

    Design of custom strategies to address real-life issues in the development of biocompatible and biomimetic devices for biotechnology or biomedical applications. Student teams will work with a client in the development of projects that incorporate materials science, biological transport and biomechanics. Formal engineering design principles will be emphasized; overview of intellectual properties, engineering ethics, risk analysis, safety in design and FDA regulations will be reviewed. Oral and written reports, and prototype development will be required. This course is intended as a capstone design course for the upper-level undergraduate biomedical engineering students with a focused interest in bimolecular science, biotechnology, transport, drug delivery, biomechanics and related disciplines. Prerequisites: BME 207, Statistics 113, or equivalent. Instructors: Gimm
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  • BME 228: Laboratory in Cellular and Biosurface Engineering (GE, MC)

    3.00 Credits
    Duke University

    Introduction to common experimental and theoretical methodologies in cellular and biosurface engineering. Experiments may include determination of protein and peptide diffusion coefficients in alginate beads, hybridoma cell culture and antibody production, determination of the strength of cell adhesion, characterization of cell adhesion or protein adsorption by total internal reflection fluorescence, and Newtonian and non-Newtonian rheology. Laboratory exercises are supplemented by lectures on experiment design, data analysis, and interpretation. Prerequisites: Biomedical Engineering 207 or equivalent. Instructor: Truskey
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  • BME 230: Tissue Biomechanics (GE, BB)

    3.00 Credits
    Duke University

    Introduction to the mechanical behaviors of biological solids and fluids with application to tissues, cells and molecules of the musculoskeletal and cardiovascular systems. Topics to be covered include static force analysis and optimization theory, biomechanics of linearly elastic solids and fluids, anisotropic behaviors of bone and fibrous tissues, blood vessel mechanics, cell mechanics and behaviors of single molecules. Emphasis will be placed on modeling stress-strain relations in these tissues, and experimental devices used to measure stress and strain. Student seminars on topics in applied biomechanics will be included. Prerequisites: Biomedical Engineering 110L or Engineering 75L; Mathematics 108. Instructor: Myers or Setton
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