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Course Criteria
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3.00 Credits
Advanced topics in physiology and medicine of ambient pressure, immersion, gravity, temperature and gas composition. Environments considered include: diving, hyperbaric medicine; hot/cold terrestrial, water operations; microgravity, high-g acceleration; high altitude,space. Basic mechanisms and medical management of: decompression sickness; altitude sickness; hypothermia and hyperthermia; hypoxia; carbon monoxide poisoning; oxygen toxicity. Practical applications: pressure vessel design, operation; life support equipment; cardiorespiratory physiology measurements at low and high pressure; simulated dive and flight (optional). Prerequisites: consent of the course instructor. Instructor: Vann
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3.00 - 9.00 Credits
Individual Research in a field of special interest under the supervision of a faculty member, the central goal of which is a substantive paper or written report containing significant analysis and interpretation of a previously approved topic. Consent of instructor required. Instructor: Staff
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2.00 Credits
This course is a graduate level introduction to the molecular mechanisms that underlie cellular processes and the experimental techniques used in cell biological research. The lectures will address the processes that cells use to organize themselves into tissues and organs, communicate through second messengers, generate specialized compartments for protein segregation, process information, move and differentiate will be addressed. Preparatory for CBI 251 and CBI 280. Minicourse, 1st half-semester. Instructor: Schachat
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3.00 Credits
Molecular diversity in structure, function and evolution of respiratory proteins. Field trips to biodiverse areas of Costa Rica and coastal NC complement text and lectures. Covers molecular adaptations that underlie macroscopic biodiversity, blood functions and blood pathogens, oxidative and nitrosative stress. Lectures and readings on the balance between pathways for metabolic oxygen utilization and alternative disease-causing pathways. (Given at Beaufort.) Field trip to Costa Rica required. Prerequisite: one semester of organic chemistry or consent of instructor. Instructor: C. Bonaventura
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4.00 Credits
This class covers a wealth of cell and molecular biology in a modular format, with modules focusing on either critical discussion of primary literature, developing quantitative/mathematical approaches to the biology, or both. Each module consists of five or six classes. Students select six (non-concurrent) modules; each module contributes to 10% of the final grade. At the end of the class, students develop a research proposal with an assigned faculty coach. All proposals are presented to the class in a 2-day symposium, contributing 40% of the final grade. Undergraduates require permission of coordinator to enroll. Instructors: Lew and Nicchitta
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2.00 Credits
Principles of modern structural biology. Protein-nucleic acid recognition, enzymatic reactions, viruses, immunoglobulins, signal transduction, and structure-based drug design described in terms of the atomic properties of biological macromolecules. Discussion of methods of structure determination with particular emphasis on macromolecular X-ray crystallography NMR methods, homology modeling, and bioinformatics. Students use molecular graphics tutorials and Internet databases to view and analyze structures. Prerequisites: organic chemistry and introductory biochemistry. Instructors: Beese and staff
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2.00 Credits
Continuation of Biochemistry 258. Structure/function analysis of proteins as enzymes, multiple ligand binding, protein folding and stability, allostery, protein-protein interactions. Prerequisites: Biochemistry 258, organic chemistry, physical chemistry, and introductory biochemistry. Instructors: Hellinga and staff
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2.00 Credits
Mechanisms of transcription, splicing, catalytic RNA, RNA editing, mRNA stability and translation. Mini-course, 2nd half semester. Instructors: Steege and Staff
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2.00 Credits
Half-semester minicourse targeted to first-year graduate students in the Biological Sciences. Taught sequentially in the Fall semester with Biology 283. Introduces basic concepts of cell specification, morphogenesis, induction, and other mechanisms that enable cells, tissues and organs to assemble the animal. Emphasis is on model organisms, mainly Drosophila, C. elegans, mouse, and zebrafish, where genomics, mutations, gene modifiers, epistasis analyses, gene knockouts, and transgenesis, plus many other genetic approaches have yielded important insights into the differentiation of cells and the development of complex organisms. Cross-listed with Biology 282. Instructors: Kirby, Klingensmith, and McClay
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2.00 Credits
Half-semester mini-course targeted to first year graduate students in the Biological Sciences. Taught sequentially in the Fall semester with Biology 282. Focuses on genetic approaches to solve mechanistic problems of development. Emphasis is on model organisms, mainly Drosophilia, C. elegans, mouse and zebrafish, where genomics, mutations, gene modifiers, epistasis analysis, gene knockouts, and transgenesis, plus many other genetic approaches have yielded important insights into the differentiation of cell and the development of complex organisms. Cross-listed with Biology 283. Instructors: Kirby, Klingensmith, and McClay
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