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Course Criteria
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3.00 Credits
Interactions of endogenous and environmental mutagens with cellular DNA. Cellular responses to damaged DNA including molecular mechanisms for DNA repair, translesion DNA synthesis, and genetic recombination. Inducible repair responses and errorprone mechanisms. Human hereditary diseases that predispose to cancer. Relationships of DNA repair to mutagenesis, carcinogenesis, aging, and human genetic disease. Current research literature. Prerequisites: 41 and 118, or consent of instructor. 3 units, Spr (Hanawalt, P)
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3.00 Credits
(Same as EARTHSYS 189.) For advanced upper-division undergraduates and graduate students. Field-based, focusing on the components and processes by which terrestrial ecosystems function. Topics from biology, chemistry, ecology, geology, and soil science. Lecture, field, and lab studies emphasize standard field techniques, experimental design, analysis of data, and written and oral presentation. Small team projects test the original questions in the functioning of natural ecosystems. Admission by application; see Axess. Prerequisites: BIO 141 or EESS 160 (formerly GES 160), or equivalent. 5 units, Spr (Chiariello, N; Dirzo, R; Field, C; Fendorf, S; Freyberg, D; Matson, P), alternate years, not given next year
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20.30 Credits
How proteins are made and degraded in the cell. Discussion of primary literature. Case studies follow the evolution of scientific ideas, and evaluate how different experimental approaches contribute to our understanding of a biological problem. Topics: protein folding and assembly, mechanisms of chaperone action, sorting into organelles and the ubiquitin-proteasome pathway. Enrollment limited to 20. 3 units, Spr (Frydman, J)
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3.00 Credits
(Same as BIO 109A, HUMBIO 158.) The variability of the human genome and the role of genomic information in research, drug discovery, and human health. Concepts and interpretations of genomic markers in medical research and real life applications. Human genomes in diverse populations. Original contributions from thought leaders in academia and industry and interaction between students and guest lecturers. 3 units, Win (Heller, R)
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3.00 Credits
(Same as BIO 109B.) Continuation of 109A/209A. Genetic drift: the path of human predecessors out of Africa to Europe and then either through Asia to Australia or through northern Russia to Alaska down to the W. Coast of the Americas. Support for this idea through the histocompatibility genes and genetic sequences that predispose people to diseases. Guest lectures from academia and pharmaceutical companies. Prerequisite: Biology or Human Biology core. 3 units, Spr (Heller, R)
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3.00 Credits
(Same as BIO 112, HUMBIO 133.) The functioning of organ systems emphasizing mechanisms of control and regulation. Topics: structure and function of endocrine and central nervous systems, cardiovascular physiology, respiration, salt and water balance, exercise, and gastrointestinal physiology. Prerequisite: Biology or Human Biology core. 4 units, Win (Garza, D)
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3.00 Credits
Principles of virus growth, genetics, architecture, and assembly. The relation of temperate viruses and other episomes to the host cell. Prerequisite: Biology core. Recommended: 118. 3 units, Win (Campbell, A)
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3.00 Credits
(Same as BIOC 224.) For Ph.D. students. Current research on cell structure, function, and dynamics. Topics include complex cell phenomena such as cell division, apoptosis, compartmentalization, transport and trafficking, motility and adhesion, differentiation, and multicellularity. Current papers from the primary literature. Prerequisite for advanced undergraduates: BIO 129A,B, and consent of instructor. 2-5 units, Win (Kopito, R; Pfeffer, S; Nelson, W; Theriot, J; Straight, A)
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3.00 Credits
Biochemical viewpoints on the evolutionary process. Topics: prebiotic biochemistry and the origins of life; adaptive organization of metabolism; enzyme polymorphisms and other biochemical aspects of population genetics; macromolecular phylogeny and protein clocks. Prerequisites: Biology core or substantial equivalent. 3 units, Win (Watt, W)
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3.00 Credits
Nutrient cycling and the regulation of primary and secondary production in terrestrial, freshwater, and marine ecosystems; landwater and biosphere-atmosphere interactions; global element cycles and their regulation; human effects on biogeochemical cycles. Prerequisite: graduate standing in science or engineering; consent of instructor for undergraduates or coterminal students. 3 units, Spr (Vitousek, P), alternate years, not given next year
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