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Course Criteria
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4.00 Credits
(Same as BIO 232, BIOPHYS 232, MCP 232.) Laboratory and lectures. Advanced microscopy and imaging, emphasizing hands-on experience with state-of-the-art techniques. Students construct and operate working apparatus. Topics include microscope optics, Koehler illumination, contrast-generating mechanisms (bright/dark field, fluorescence, phase contrast, differential interference contrast), and resolution limits. Laboratory topics vary by year, but include single-molecule fluorescence, fluorescence resonance energy transfer, confocal microscopy, two-photon microscopy, and optical trapping. Limited enrollment. Recommended: basic physics, Biology core or equivalent, and consent of instructor. GER:DB-NatSci 4 units, Spr (Block, S; Schnitzer, M; Smith, S; Stearns, T)
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3.00 Credits
Genetic approaches for understanding cellular processes in bacteria, including metabolism, adaptive and stress responses, signal transduction, gene expression, genetic exchange and recombination, chromosome dynamics and evolution, cell division, motility, surface attachment, and developmental responses. Emphasis is on the power of effectively combining genetics with biochemistry, microscopy, and genomics. Prerequisite: Biology core. GER:DB-NatSci 4 units, Aut (Burkholder, W; Campbell, A), alternate years, not given next year
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3.00 Credits
Seminar. Modes of DNA replication and their control in prokaryotes and eukaryotes. Structures, properties, and functions of DNA polymerases and associated factors. Emphasis is on experimental approaches and their limitations. Current research literature. Students prepare journal club style report and lead class discussions. Enrollment limited to 20 advanced undergraduates. Prerequisite: Biology core. Recommended: 118. GER:DB-NatSci 3 units, Win (Burkholder, W)
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3.00 Credits
(Same as HUMBIO 186.) The biological basis for endogenous timekeeping in organisms from flies to human beings. How biological clocks are constructed at the molecular, tissue, and behavioral levels; how these clocks interact with other physiological systems and allow animals to anticipate changes in their environment. Applications of circadian rhythm principles to treating human disorders and diseases such as cancer. Prerequisite: Biology or Human Biology core, or consent of instructor. GER:DB-NatSci 3 units, not given this year
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4.00 Credits
A paleontological approach to evolutionary theory. History of life, speciation, heterochrony, evolutionary constraint, coevolution, macroevolution, Cambrian Explosion, mass extinctions, taphonomy, life on land, life in the sea, life in the air. GER:DB-NatSci 4 units, not given this year
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3.00 Credits
(Same as BIO 237.) Gene analysis, mutagenesis, transposable elements; developmental genetics of flowering and embryo development; biochemical genetics of plant metabolism; scientific and societal lessons from transgenic plants. Prerequisite: Biology core or consent of instructor. GER:DB-NatSci 3-4 units, Spr (Walbot, V)
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3.00 Credits
How birds interact with their environments and each other, emphasizing studies that had impact in the fields of population biology, community ecology, and evolution. Local bird communities. Emphasis is on field research. Enrollment limited to 20. Prerequisites: 43 or equivalent, and consent of instructor. Recommended: birding experience. GER:DB-NatSci 3 units, Spr (Root, T), alternate years, not given next year
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3.00 Credits
(F,Sem) Stanford Introductory Seminar. Preference to freshmen. Students do independent investigations of current environmental problems, analyzing differing views of them and discussing possible solutions. Each student gives two seminar presentations and leads two seminar discussions. Short, documented position papers are written for policy makers. GER:DB-NatSci 3 units, Spr (Ehrlich, P)
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3.00 Credits
Field work on Euphydryas populations under study on campus and elsewhere in California. Course offered as participation in research when conditions permit; decisions not made until Winter Quarter. Prerequisites: 43 and consent of instructor. 2-5 units, not given this year
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4.00 - 5.00 Credits
(Same as STATS 141.) Introductory statistical methods for biological data: describing data (numerical and graphical summaries); introduction to probability; and statistical inference (hypothesis tests and confidence intervals). Intermediate statistical methods: comparing groups (analysis of variance); analyzing associations (linear and logistic regression); and methods for categorical data (contingency tables and odds ratio). Course content integrated with statistical computing in R. See http://wwwstat. stanford.edu/~rag/stat141/. GER:DB-Math 4-5 units, Aut (Boik, J; Rogosa, D)
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