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Course Criteria
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3.00 Credits
08F, 09F: 9; Laboratory A graduate section of Engineering Sciences 35 involving a project and extra class meetings. Not open to students who have taken Engineering Sciences 35. Prerequisite: Mathematics 3, Chemistry 3 or 5, Biology 12 or 13 and permission of the instructor. Gerngross.
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3.00 Credits
10S: 11 Offered in alternate years A consideration of practical and theoretical aspects of modifying metabolic pathways to produce products of interest. After reviewing basic principles of metabolism and the scope of the metabolic engineering field, case studies of metabolic engineering will be examined including detailed consideration at a genetic level. Thereafter, techniques and applications of metabolic modeling will be considered, including structured modeling and metabolic control theory. Prerequisite: Engineering Sciences 160, a non-introductory course in biochemistry or molecular biology, or permission. Gerngross, Lynd.
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3.00 Credits
09S: Arrange Offered in alternate years This is a laboratory based course designed to provide hands on experience with modern biotechnological research, high throughput screening and production tools. The course provides familiarity with processes commonly used in the biotechnology industry. Examples include fermentation systems controlled by programmable logic controllers, down stream processing equipment such as continuous centrifugation, cross flow ultra-filtration and fluidized bed chromatography. The laboratory also demonstrates the substitution of routine molecular biological and biochemical operations by automated liquid handlers and laboratory robots. Students design and develop a bioassay, which is then implemented by laboratory robots for which they have to write their own implementation program. The course has a significant laboratory component. Enrollment is limited to 12 students. Prerequisites: one from Engineering Sciences 35, 160, and 161, or one from Biology 61, 64, and 65. Griswold.
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3.00 Credits
09S: Arrange Consideration of material problems is perhaps one of the most important aspects of prosthetic implant design. The effects of the implant material on the biological system as well as the effect of the biological environment on the implant must be considered. In this regard, biomaterial problems and the bioelectrical control systems regulating tissue responses to cardiovascular and orthopedic implants will be discussed. Examples of prosthetic devices currently being used and new developments of materials appropriate for future use in implantation will be taken from the literature. Prerequisite: Engineering Sciences 24, or equivalent. Van Citters.
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3.00 Credits
08F: 10 Offered in alternate years A comprehensive introduction to all major aspects of standard medical imaging systems used today. Topics include radiation, dosimetry, x-ray imaging, computed tomography, nuclear medicine, MRI, ultrasound, and imaging applications in therapy. The fundamental mathematics underlying each imaging modality is reviewed and an engineering picture of the hardware needed to implement each system is examined. The course will incorporate a journal club review of research papers, term tests, and a term project to be completed on an imaging system. Prerequisites: Engineering Sciences 23 or equivalent. Pogue.
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3.00 Credits
Not offered in the period from 08F through 10S An interdisciplinary scientific investigation of contemporary global environmental issues. Weekly seminars by distinguished environmental scientists form the basis of each week's activity. A structured critical review of the literature will be prepared by each student for each week's discussion. Additionally, each student will be responsible for compiling a term paper that goes beyond the class coverage of one of the weekly topics.This course is open to graduate students in the sciences, and to advanced undergraduates by permission. Enrollment will normally be limited to 20, with emphasis on interdisciplinary participation within the Science Division. Prerequisite: Graduate standing, or permission.
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3.00 Credits
09S, 10S: 2 By studying the flow of materials and energy through industrial systems, industrial ecology identifies economic ways to lessen negative environmental impacts, chiefly by reducing pollution at the source, minimizing energy consumption, designing for the environment, and promoting sustainability. The objective of this course is to examine to what extent environmental concerns have already affected specific industries, and where additional progress can be made. With the emphasis on technology as a source of both problems and solutions, a broad spectrum of industrial activities is reviewed ranging from low-design high-volume to high-design low-volume products. Students activities include a critical review of current literature, participation in class discussion, and a term project in design for the environment. Prerequisite: Engineering Sciences 21 and 37. Cushman-Roisin.
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3.00 Credits
09S, 10S: 2A The current assessment by the Intergovernmental Panel on Climate Change (IPCC) of the World Meteorological Organization (WMO) and the United Nations Environment Programme (UNEP) will be examined. The course will begin by scrutinizing the scientific basis of the assessment. Subsequently, regional and global impact projections will be examined. The technological options will be examined with respect to research and capitalization priorities, both corporate and governmental. Finally, the possibilities for novel governance structures based on a scientific understanding will be examined. Weekly critical presentations of the source material will be required. The course will culminate in the preparation, presentation, and refinement of a term paper of the student's choosing. Prerequisite: Junior or senior standing in the Science Division; graduate standing in engineering or science; or permission. Lynch.
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3.00 Credits
09S, 10S: 10A; Laboratory A seminar on human-centered design for advanced students offered as an introduction to professional practice in product design. Includes a major emphasis on human factors in product development. Individual or group design projects carried to high level of development will form the vehicle for exploring creative strategies for optimizing product design for human use. Course includes frequent (5-8) discussions and project critiques with visiting professional designers. Enrollment limited to 16. Prerequisite: Engineering Sciences 21 or 190, 75, 76 or 146. Robbie, Collier.
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3.00 Credits
08F, 09F: 2A This course explores elements of the engineering design process as a means of enhancing student ability in problem definition; development and evaluation of creative alternatives,application and methods of technical and economic analysis, identification and application of ethical and legal constraints, and effective presentation of technical information. Design projects are developed from specifications submitted by industry and other organizations and are pursued over the course of two quarters as a team project (190/290). Written and oral proposal and progress report are required for the design project during the term. A project advisor is required for each design team to serve as consultant to the team's efforts. Engineering Sciences 190 is the first unit of a two-term course sequence (190/290) that must be taken consecutively. Prerequisites: Prior to enrollment in 190, at least six engineering courses must be completed. These include Engineering Sciences 21 plus five additional courses numbered 22 to 76. Van Citters.
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