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Course Criteria
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3.00 Credits
10S: 10 Many genomes, including the human genome, have been sequenced. Now, increasing attention has turned to a cryptic, yet fundamental component of these genomes: gene circuitry, i.e. the "wiring" that links together activated genes in a genomic program. Specialized DNA sequences determine where and when a given gene is expressed during an organism's life cycle. These genomic "regulatory" sequences play a major role in basic evolutionary processes. How do regulatory sequences encode differential gene expression How do they evolve How do we identify and decode them This course will investigate these questions as well as landmark papers necessary to understand present and future work in this field. Offered in alternate yeaPrerequisites: One of the following: Biology 39, 43, 45 or 47. Dist: SCI. Erives.
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3.00 Credits
09S: 3A Methods and strategies for the analysis of gene structure, function and genetic interactions. The course will examine how the genetic manipulation of model organisms, including yeast, Drosophila, C. elegans, and mouse, is used to explore the mechanisms of fundamental biological processes such as cell division, development, and intercellular communication. Emphasis will be placed on the application of classical genetic methods, including mutant screens, recombination and complementation analysis, genetic mosaics, and the use of conditional mutations. Modern molecular-based approaches, including gene knockout, gene dosage and misexpression studies will also be included. Three hours of lecture and one hour of discussion per week. Prerequisites: Biology 12 and 13 and one from among Biology 38, 45, 47 or permission of instructor. Dist: SCI. Berger.
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3.00 Credits
09W, 10W: 9L Knowledge of molecular mechanisms allows new approaches to understanding human biology and disease. This course will explore the normal and abnormal biology of several human conditions relying on biochemistry, molecular genetics, and physiology as tools of inquiry. Examples will be drawn from the histories of John Hunter, Mona Lisa, Michel-Eugène Chevruel, Hendrickje St ffels. Bobby Sands, Paul Cézanne, Lance Armstrong, Pearl Buck and Auguste D. among others.Prerequisites: Biology 13 and 40 (or Chemistry 41) or permission of instructor. A prior course on some aspect of mammalian physiology is recommended (e.g. Biology 2, 14, 35 or 37). Dist: SCI. Witters.
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3.00 Credits
Not offered in the period from 08F through 10S Examination of the genetic, physiological, cellular, and molecular basis of behavior and responses to environmental factors in eukaryotic organisms. Topics to be covered from the current and classic literature will include circadian rhythmicity, learning and memory, and other areas of current research, and will vary somewhat from year to year. Prerequisites: Biology 45 and permission of the instructor Dist: SCI.
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3.00 Credits
09S, 10S: 2A This course teaches the fundamentals of clinical biomedical research (CBR). The CBR curriculum offers a unique combination of direct involvement in ongoing clinical research studies with a comprehensive didactic program and experience conducting and designing clinical studies. Designated as Academic Associates, the students will spend time in the DHMC Emergency Department (E.D.) playing an integral role in patient identification, enrollment, and data collection for the ongoing clinical research studies. Coupled with this "hands-on" data collection in the E.D., the didactic program consists of weekly classes focusing on research design, data collection techniques, statistical analysis, and scientific poster preparation. At the completion of the course, each student will develop a "mock clinical research study?rerequisites: Biology 12 and 13 and permission of the instructor. Biology 2 and either 29 or Mathematics 10 are also recommended. Dist: SCI. Curtis.
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3.00 Credits
All terms: Arrange Original and independent investigation of a problem in the history and/or philosophy of biology with associated study of primary literature sources under supervision for one academic term. Biology 9 does not count for biology major or minor credit. Prerequisites: At least one Biology course and permission of the chair of the Undergraduate Committee and the supervising instructor. The application and research proposal must be submitted at least one month prior to the beginning of the term in which the course is to be elected. Dietrich.
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1.00 Credits
All terms: Arrange Original and independent investigation of a biological problem with associated study of primary literature sources under the supervision of a member of the staff for one academic term. Open only to Dartmouth Biology majors and minors. Projects may include laboratory or field research or modeling that will further understanding of a relevant basic or applied research problem. May be taken as one course in the major by students not enrolled in the honors program. Students electing both Biology 95 and Biology 97 may count only one among the six courses in the area of concentration. In no case may a student elect more than two courses among Biology 95, 96, and 97. Prerequisites: at least two Biology courses above the foundation level, a 2.67 average in previous biology courses, and permission of the chair of the Undergraduate Committee and the supervising instructor. The application and research proposal must be submitted at least one month prior to the beginning of the term in which the course is to be elected. The staff.
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3.00 Credits
All terms: Arrange A second term of original and independent investigation of a biological problem under the supervision of a member of the staff. Open only to Dartmouth Biology majors who have satisfied the requirements for Biology 95 and who wish to continue their independent research for a second term. Does not count for credit in the major. Prerequisites: Satisfactory completion of Biology 95 (including research paper) and permission of both the chair of the Undergraduate Committee and the supervising instructor(s). The application and research proposal must be submitted at least one month prior to the beginning of the term in which the course is to be elected. The staff.
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3.00 Credits
All terms: Arrange Original and independent investigation of a biological problem with associated study of primary literature sources under the supervision of a member of the staff. Open only to Dartmouth Biology majors. Projects may include laboratory or field research or modeling that will further understanding of a relevant basic or applied research problem. Required of honors students as part of the major. Students taking both Biology 95 and Biology 97 may count only one term toward the elective courses for their major. In no case may a student elect more than two courses among Biology 95 and 97. Students who have completed or are taking Biology 97 may enroll and receive college credit for Biology 99 during spring term of their senior year. Prerequisites: at least two Biology courses above the foundation level, a 3.0 average in previous Biology courses, and permission of the chair of the Undergraduate Committee and the supervising instructor, obtained at least one month prior to the beginning of the term in which the course is to be elected. The staff.
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3.00 Credits
09S, 10S: 2 This course will focus on presentation techniques and critical evaluation of other students' research and presentations. Students who have conducted Independent Research will present background information related to their research projects, develop seminars based on their own findings, and receive feedback. All students taking Biology 97 are encouraged to enroll in this course. Prerequisites: Senior standing and previous or current enrollment in Biology 97. Grotz.
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