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  • 3.00 Credits

    All terms: Arrange An original individual experimental or theoretical investigation beyond the undergraduate level in biochemistry. This course is open only to graduate students subsequent to passing their qualifying exam; it may be elected for credit more than once. This course carries two course credits and should be elected by students electing only departmental colloquia in addition to research. Barlowe and the staff of the Program.
  • 3.00 Credits

    All terms: Arrange An original individual experimental or theoretical investigation beyond the undergraduate level in biochemistry. This course is open only to graduate students subsequent to passing their qualifying exam; it may be elected for credit more than once. This course carries three course credits and should be elected by students conducting research exclusively in any one term. Barlowe and the staff of the Program.
  • 3.00 Credits

    09X: 10A An introductory survey of the history of modern biology from Charles Darwin to the present. This course will consider major developments in biology such as Darwin's theory of evolution, experimental embryology and the revolt against morphology, Mendelian genetics and the eugenics movement, the rise of ecology and Neo-Darwinism, and the impact of molecular biology. We will emphasize the development of biology as an experimental science and the social context for biological thought and practice. Open to all students without prerequisite. Dist: SCI. Dietrich.
  • 3.00 Credits

    08F: 9L, 10A 09W: 10A 09S: 9L 09F: 9L, 10A 10W: 10A10S: 9L Biology, like all of science, is a problem-solving endeavor. This course introduces students to a major problem in biology and considers it from many different perspectives, viewpoints and biological levels of organization. Along the way, students are exposed to many of the major concepts in biology, from molecules to ecosystems. Each offering will address a different major problem. Open to all students without prerequisite. Dist: SCI. In 08F at 9L, DNA to Diversity. We have chosen "DNA to Diversity" as a theme because we want to highlight how modern biology integrates all levels from the molecule to the diversity of life. As an organizing principle, we focus on the development of complex multicellular organisms. We will explore how cellular processes are driven by key developmental control genes, how cells communicate, and how these molecular and cellular mechanisms shape diverse forms of life. We will investigate how ecological forces drive natural selection, and how this and other evolutionary processes have sorted and sifted DNA mutations, producing DNA blueprints that direct development. Over the course of the term, students should gain a perspective on how genetic and environmental changes have produced the astonishing variety of species and life forms that now exist on earth, and how biologists are piecing that puzzle together. Jack, Peart.In 08F at 10A, Cooperation and Conflict in Biological Systems. Cooperation and conflict arise at all levels of biology-with molecules, cells, organisms and communities. Throughout the term, we will explore several examples of cooperation and conflict in biological systems and examine the cost and benefits of these two opposing forces. We will investigate theories about how cooperation and/or conflict have shaped how life began, the concept of "selfish" DNA, why cells have the structures they have as well as multi-protein complexes driving essential cellular processes. In addition, we will discuss the generation of multicellular organisms, cooperation of different cell types within the organism and examples of cellular competition that arise in specific diseased states such as cancer. We also will consider behavioral interactions among different types of organisms, and the organization of human societies. Ultimately, our goal is to guide students to critically evaluate the different ways that cooperation and conflict shape biological systems and to begin to understand the mechanisms underlying these two forces. Bickel, CalsbeekIn 09W at 10A, LUCA: the Last Universal Common Ancestor. Over the course of the last 4.5 billion years, life has faced a number of challenges, and in response has evolved a number of remarkable innovations to meet those challenges. Incorporating data and perspectives from molecular and cellular biology, macroevolutionary theory, and paleobiology, we will reconstruct the biology of the Last Universal Common Ancestor of all living organisms. Her name is LUCA and unraveling her biology will require us to work within the framework of what it means to be a living cell. We will move forward in time from the origin of life, and backward in time from the remarkable diversity of life present today. We will see that much of LUCA's biology has left "molecular fossils" in our very own DNA, and we will learn how to read this remarkable fossil record. Peterson, SlobodaIn 09S at 9L, Emerging infectious diseases: how microbes rule the world. Emerging infectious diseases, which have shaped the course of humanity and caused untold suffering and death, will continue to challenge society as long as humans and microbes co-exist. This course will explore why infectious diseases emerge and re-emerge. The viruses, bacteria and eukaryotes that cause these diseases continually evolve in response to their hosts. Dynamic interactions between rapidly evolving infectious agents and changes in the environment and in h
  • 3.00 Credits

    08F, 09S, 09F, 10S: 9L; Laboratory: Arrange Biology 12 will provide a foundation in the fundamental mechanisms that govern the structure and function of eukaryotic cells. Topics include membrane transport, energy conversion, signal transduction, protein targeting, cell motility and the cytoskeleton, and the cell cycle. Emphasis will be placed on discussion of the experimental basis for understanding cell function. The laboratory section will provide students with hands-on experience in modern laboratory techniques including microscopy, cell fractionation, and protein purification. Prerequisite: Biology 11. Biology 12-16 may be taken in any order. Dist: SLA. Gladfelter, Schaller.
  • 3.00 Credits

    09W: 9L 09X: 10 10W: 9L; Laboratory: Arrange This course provides a foundation in genetics and molecular biology. Topics covered include the flow of genetic information from DNA to RNA to protein, transmission of genetic information from one generation to the next and the molecular mechanisms that control gene expression in bacteria and eukaryotes. These concepts will be integrated into a discussion of contemporary problems and approaches in molecular genetics. Laboratories utilize basic molecular biology techniques to further investigate topics discussed in lecture. Prerequisite: Biology 11. Biology 12-16 may be taken in any order. Dist: SLA. Lambie, Grotz.
  • 3.00 Credits

    09W: 1009X: 10A10W: 10; Laboratory: Arrange This course introduces students to the complexity of organisms by studying how their different organ systems strive to maintain internal homeostasis in the face of different environmental demands. The adaptive responses of selected organisms (humans, different animals and plants) to a variety of environmental factors will be studied from the molecular, cell, tissue, organ, and systems level of organization. Some of the topics to be covered include biological control systems (hormones, neurons) and coordinated body functions (circulation, respiration, osmoregulation, digestion). All systems studied will be integrated by analyzing how different organisms adapt to living in extreme environments (deserts, high altitude) or facing environmental demands (navigation, exercise). Prerequisite: Biology 11. Biology 12-16 may be taken in any order. Dist: SLA. Vélez, Rendi.
  • 3.00 Credits

    09S, 10S: 11; Laboratory: Arrange A consideration of the genetics of natural populations and the process of organic evolution. Topics include the source and distribution of phenotypic and genotypic variation in nature; the forces which act on genetic variation (mutation, migration, selection, drift); the genetic basis of adaptation, speciation, and phyletic evolution. Prerequisites: Biology 11. Biology 12-16 may be taken in any order. Dist: SLA. Kern.
  • 3.00 Credits

    08F, 09S, 09F, 10S: 10; Laboratory: Arrange This course examines fundamental concepts in the rapidly developing areas of ecology. These topics include the factors that limit the distributions and abundances of organisms, the effects that organisms have on ecosystems, the integration of ecosystems around the globe, and the conservation of species diversity. The class will also explore how the behavior and physiology of individual organisms shape both local and global patterns of distribution and abundance. Laboratories focus on experimental and quantitative analyses of local ecosystems, with an emphasis on field studies. Prerequisite: Biology 11 or permission of the instructor. Biology 12-16 may be taken in any order. Dist: SLA. Irwin, Mbora.
  • 3.00 Credits

    08F, 09F: 11 A course designed to help students (biologists and non-biologists) understand the biological basis of human health and disease. The course will emphasize the fundamental aspects of biochemistry, genetics, cell and molecular biology, physiology, anatomy, reproductive biology, and function of various organs as they relate to humans. Particular emphasis will be placed on specific topics in human health and disease and how these issues affect us all individually in our own health and collectively in our international society. Open to all students without prerequisite. Dist: SCI. Witters.
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