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Course Criteria
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3.00 Credits
(291) Either semester. Credits and hours by arrangement. Open with consent of instructor. May be repeated for credit with change in topic. Laboratory research project carried on by the student under the guidance of a faculty member. The student is required to submit a brief report on the research findings at the end of the semester.
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3.00 Credits
Either semester. Three credits. Hours by arrangement. Prerequisite: At least three credits of MCB 3989 or 4989, which may be taken concurrently. Prerequisite: ENGL 1010 or 1011 or 3800; open with consent of instructor. Writing of a thesis based upon the student's independent laboratory research project.
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3.00 Credits
(208) Second semester. Three credits. Prerequisite: MCB 3007, or CHEM 3563 or instructor consent. The characterization of biological macromolecules (i.e. proteins and nucleic acids) in solution is important to the biotechnology and pharmaceutical industries. This course deals with hydrodynamic techniques (i.e. diffusion, electrophoresis, sedimentation, light scattering, and viscosity) for molecular size and shape, and spectroscopic methods (such as circular dichroism) for more detailed structure.
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3.00 Credits
(209) Second semester. Three credits. Prerequisite or corequisite: MCB 2000 or 3010 or instructor consent. Fundamentals of protein structure and the forces that stabilize structure. Topics include recurrent structural motifs, molecular ancestry/homology, evolution of protein structure, structure-function correlations, and the structural basis of regulation. Discussion of the techniques used to investigate structure, including X-ray diffraction, NMR, TEM, AFM, structure prediction, and computational simulations. Advanced topics may include chaperones, structural genomics and the roles of misfolded proteins in disease.
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4.00 Credits
(226W) Second semester. Four credits. One 1-hour lecture and two 4-hour laboratories. Prerequisite: Either MCB 3010 or 2000 with instructor consent; ENGL 1010 or 1011 or 3800. Theory and application of modern techniques for separation and characterization of biological macromolecules, including several types of liquid chromatography, liquid scintillation spectrophotometry, and SDS polyacrylamide gel electrophoresis. Instruction in writing a scientific paper. A fee of $20 is charged for this course.
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3.00 Credits
(219) Second semester. Three credits. Prerequisite: BIOL 1107. Recommended preparation: MCB 2210 and 2410 or 2413, which may be taken concurrently. Principles of embryogenesis, pattern formation, and cell differentiation. The focus will be on molecular and cellular aspects of development in several experimental systems, including the mouse, fruit fly, amphibians, and marine invertebrates. Regeneration and stem cell biology will be discussed. Relevance to human development and disease will be emphasized.
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3.00 Credits
(215) First semester. Three credits. One 1-hour lecture and two 3-hour laboratory periods. Open only with consent of instructor. Recommended preparation: MCB 3010; 3412 or 3617. Not open for credit to students who have passed MCB 230. Modern methods in molecular genetics arranged to meet a research goal. Use of polymerase chain reaction, bacteriophage library screening, molecular cloning, nucleic acid hybridizations, and DNA sequence determinations to isolate and characterize a eukaryotic gene. A fee of $20 is charged for this course.
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3.00 Credits
(224) Second semester. Three credits. Two 3 1/2 hour laboratory/lecture periods. Prerequisite: MCB 2610. Recommended preparation: MCB 3617. Open only with instructor consent. Experiments in bacterial genetics, emphasizing genetic manipulations and analyses using modern biological techniques including transposon mutagenesis, DNA isolation, PCR, DNA sequencing and phenotypic analysis.
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3.00 Credits
(297) Either or both semesters. Credits and hours by arrangement. Open only with consent of instructor. May be repeated for credit with a change of topic.
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3.00 Credits
(293) Either semester. Credits and hours by arrangement. Open only to honors students with consent of instructor. May be repeated for credit with change in topic. Laboratory research project carried on by the student under the guidance of a faculty member. The student is required to submit a brief report on the research findings at the end of the semester.
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