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Course Criteria
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3.00 Credits
Advanced study of re DNA techniques; bioreactor design for bacteria, mammalian and insect culture; separation methods; chromatography; drug and cell delivery systems; gene therapy; and diagnostics.
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3.00 Credits
Discher. Prerequisite(s): Background in Biology, Chemistry or Engineering with coursework in thermodynamics or permission of the instructor. From single molecule studies to single cell manipulations, the broad field of cell and molecular biology is becoming increasingly quantitative and increasingly a matter of systems simplification and analysis. The elaboration of various stresses on cellular structures, influences of interaction pathways and convolutions of incessant thermal motions will be discussed via lectures and laboratory demonstration. Topics will range from, but are not limited to, protein folding/forced unfolding to biomolecule associations, cell and membrane mechanics, and cell motility, drawing from very recent examples in the literature. Frequent hands-on exposure to modern methods in the field will be a significant element of the course in the laboratory. Skills in analytical and professional presentations, papers and laboratory work will be developed.
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3.00 Credits
This course will cover current state of the art in engineering approaches to design, optimization, and characterization of biomolecules. Particular emphasis will be placed on proteins. Fundamental physical biochemistry of biological macromolecules will be reviewed to provide a basis for understanding approaches to de novo protein design, combinatorial directed evolution, methods for analysis of structure and function, and practical applications for this class of molecules. Much of the course material will be drawn from the current literature.
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3.00 Credits
Drug Discovery and Development
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3.00 Credits
New drug development and regulatory compliance related to small molecules and biologics, overview of biopharma industry, regulation and development process for new chemical entities and biolgies, formulation of pharmaceutical dosage forms, current Good Manufacturing Practices, chemistry manufacture and controls, overview of Common Technical Document (CTD), managing post-approval changes - formulatin, process, packaging, and analytical.
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3.00 Credits
PID control of nonlinear systems; steady-state, periodic and chaotic attractors. Multiple-input, multiple-output systems; decoupling methods and decentralized control structures. Digital control; z-transforms, implicit model control, impact of uncertainties. Constrained optimization; quadratic dynamic matrix control. Nonlinear predictive control. Transformations for input/output linearized controllers.
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3.00 Credits
Review of classical thermodynamics. Phase and chemical equilibrium for multicomponent systems. Prediction of thermodynamic functions from molecular properties. Concepts in applied statistical mechanics. Modern theories of liquid mixtures.
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3.00 Credits
An introduction to statistical mechanics and its applications in chemical engineering. Ensembles. Monatomic and polatomic ideal gases. Ideal lattices; adsorption and polymer elasticity. Imperfect gases. Dense liquids. Computer simulation techniques. Interacting lattices.
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3.00 Credits
Mechanisms of chemical reactions. Transition state theory. Langmuir-Hinshelwood Kenetics. Absorption and cataysis. Simple and complex reaction schemes. Design of idealized reactors. Fluidized reactors. Solid-gas reactions. Residence time distributions. Reaction and diffusion in solid catalysts. Reactor stability and control.
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3.00 Credits
The course provides an unified introduction to momentum, energy (heat), and mass transport processes. The basic mechanisms and the constitutive laws for the various transport processes will be delineated, and the conservation equations will be derived and applied to internal and external flows featuring a few examples from mechanical, chemical, and biological systems. Reactive flows will also be considered.
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