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Course Criteria
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3.00 Credits
Krummenacher, C. Lieberman, P. Weiss, S. Bergelson, J. Non- CAMB students must obtain instructor approval. This seminar course covers current topics and important concepts in virology. Students will read papers from the literature on specific topics in virology, and then present a seminar with the guidance of a faculty member. Grades will be based on the quality of the seminar(s) and participation in class discussions.
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3.00 Credits
Doug Epstein. Topics and course instructors vary yearly. The seminar focuses on classic papers and the intellectual development of thought in cell and molecular biology. Multiple sections are taught by faculty from the different programs within the Graduate Group. Required course for CAMB PhD Students. Other BGS students eligible space-permitting.
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3.00 Credits
T. Kadesch. Prerequisite(s): BIOM 555 (or equivalent) and permission of instructor. Exceptions for MD/PhD students. CAMB students will receive priority. An advanced seminar course emphasizing the molecular biology and molecular genetics of transcription in eukaryotes. Based on the current literature, the presentations and discussions will familiarize the student with present day technology and developing principles.
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3.00 Credits
David Weiner, Ph.D., Paul Offit, M.D., Dr. Jean Boyer. Vaccination is perhaps the most successful medical intervention. The goal of this course is to expand on students' general understanding of the immune system and to focus this understanding towards the application of vaccination. Furthermore, the course will give the student a sense of how these principles are applied to vaccine and immune therapeutic development. The course covers basic science as well as the clinical, ethical, and political implications of modern vaccines. Initial lectures review immune mechanisms believed to be responsible for vaccine induced protection from disease. Subsequent lectures build on this background to explore the science of vaccines for diverse pathogens, including agents of bioterrorism as well as vaccines for cancer. An appreciation for the application of laboratory science to the clinical development of vaccines is provided in the next section of the course along with lectures, which focus on the ethical implications of vaccines in different situations. The financial implications of specific vaccines on the global community is one specific focus of the course. The course is lecture style and has a required reading to provide the student background for the specific topic. Students are graded on course participation, a project and a final written exam. The project is to propose in a written report a vaccine strategy for a current pathogen of importance that does not as yet have an effective vaccine. Strategies used should build on the material presented in the class lectures. The course is intended for graduate students or medical students in various MS, Ph.D., or MD/Ph.D. programs on the campus as well as local scientists and professionals in the community. As a prerequisite students should have taken biology, biochemistry, or immunology courses at the advanced college level.
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3.00 Credits
Wilson. Prerequisite(s): Background in biochemistry, cell biology, and molecular biology. Any student not enrolled in a BGS graduate course who wishes to take this course must receive permission from Dr. Wilson (wilsonjm@mail.med.upenn.edu). This is a team-taught, survey course that focuses on the basic science relevant to achieving efficient and effective gene transfer in animal models and humans for the treatment of disease. The course includes a unit devoted to a variety of vectors useful for gene transfer, with the remainder of the course devoted to the study of current gene therapy approaches using specific diseases as models. Prior background in biochemistry, cell biology, and molecular biology is essential. Aspects of organ system anatomy and physiology, virology, and immunology that are relevant to the course material are included in the course. Because of rapid movement in this field, specific topics vary somewhat from year to year. Offered every fall.
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3.00 Credits
Yair Argon;Harry Ischiropoulos. Prerequisite(s): BIOM 600 or equivalent. Protein misfolding and aggregation have been associated with a number of human diseases, ranging from Alzhemier's and Parkinson's Disease to Respiratory Distress Syndrome, alpha(1)-antitrypsin deficiency and Mad Cow Disease. This course will cover the common principles underlying such diverse diseases. The course will consist of lectures, directed readings, and student presentations and will cover seminal and current papers on the cell biology of conformational diseases. Examples of topics are cellular inclusion bodies, protein degradation pathways (proteosome vs. ER-associated degradation), effects of protein aggregation on cell function and mutations which lead to autosomal dominant diseases. Target audience is primarily 1st year CAMB students or other students interested in acquiring a cell biological perspective on the topic. MD/PhDs and Postdods are welcome.
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3.00 Credits
Neal Nathanson. Prerequisite(s): Introductory courses in virology (or microbiology) and in immunology are recommended. First priority to virology students - 2nd priority to CAMB students. This course reviews the fundamentals of viral pathogenesis, and covers the following general areas: virus cell interactions, viral tropism and cellular receptors, sequential steps in viral infection; immune responses to viral infections, virus-induced immunopathology, virus-induced immunosuppression; viral virulence; iral persistence, oncogenic viruses, host susceptibility to viral diseases, HIV and AIDS; viral vaccines.
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3.00 Credits
DiNardo, S. Prerequisite(s): BIOM 600 (CELL 600); Gene Regulation. The goal of this seminar course is to foster discussion about general strategies used by cells and organisms to solve fundamental problems during development. This is not a survey course in Developmental Biology. Rather, we focus on an overarching theme for the semester (see below), enabling us to define the issues central to that theme, and explore attempts to uncover solutions using different model systems. Primary research papers are assigned for discussion, and all students are expected to contribute thoughtfully and energetically to the discussion each week. Prior years' topics have been: "Cell migration in Development", "Evolutionary Development", "Developmental links to Disease", "Cell Biology in Development", "Stem Cells", "Rulers, Clocks & Oscillators in Development". Offered fall semester.
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3.00 Credits
N. Spinner, T. Shaikh, , E. Shore, M. Devoto, S. Grant. Prerequisite(s): CAMB 550 or discuss with faculty. Building on the foundations of the Human Genome and HapMap projects, as well as parallel efforts in model organisms, research in human genetics and genomics is progressing rapidly. Our understanding of basic concepts in genetics, and Mendelian and non-Mendelian human genetic disease is proceeding at an unprecedented pace. This course will provide students with an overview approaches to understanding current problems and techniques in human genetics. The format will be an advanced seminar course, with directed reading and students presentations. Every week, students are expected to participate in a 2-hour class session, and two students will present recent publications in human genetics and disease. After each session, instructors will meet with presenting students for 30 min. to provide individual feedback. Course directors will attend each class, and guest preceptor with relevant scientific expertise may also participate. Students will be assigned readings for the first half of the course, and then select their own papers for the second half of the course. Presentations will be prepared in consultation with course directors. Students must meet with instructors at least one to two weeks prior to the presentation date. In class, the student discussion leaders will i) present background information necessary to understand the assigned paper (10-15 min.), ii) lead discussion of the paper, focusing on critical evaluation of the methods and results, and iii) talk about the future directions for this research. A short written assignment will be due by the end of the course. This written work will be in the form of a review piece or "news and views" format commonly seen in scientific journals. The topic of this review can be based on one of the two topics the student presents in class, or on a separate topic approved by the instructors. The review should be approximately 1,000 words or less (no more than 4 double-spaced pages). Grading: Students will be evaluated based on class participation (25%), their first presentation (25%) and their second presentation (25%), and the written assignment (25%).
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3.00 Credits
Dave Boettiger, Jeff Field. Prerequisite(s): BIOM600 or similar course in molecular cell biology. Limited to BGS, SAS, and Engineering graduate group students. Others by permit only. This is a seminar course in the molecular mechanisms underlying the organization, dynamics and signaling through cell adhesion and the cytoskeleton. The course will cover the basic principles and biology of the molecules involved in cell-cell and cell-matrix adhesion and their interface with the cytoskeleton. This is an advanced seminar course. Students will present papers that will be selected to highlight classical and emerging methods including genetic screens, pharmacological studies, physical approaches, and genomic approaches. The issues addressed include regulation of cell adhesion, control of cell motility, and roles of adhesion and adhesion signaling in cancer and cardiovascular disease. Students will also present one paper of their own choosing. All presentations will be prepared in consultation with a faculty member with expertise in the specific area. The course requires a minimum of seven registered students to be offered.
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