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Course Criteria
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3.00 Credits
A. Gitler, T. Lamitina. Prerequisite(s): CAMB 605 or CAMB 542 or permission of the instructor. Class is not open to undergraduates and will give priority to CAMB graduate students. An advanced seminar course emphasizing genetic research in model organisms and how it informs modern medicine. Each week a student will present background on a specific human disease. This is followed by an intense discussion by the entire class of ~2 recent papers in which model organisms have been used to address the disease mechanism and/or treatment. As a final assignment, students will have the opportunity to write, edit, and publish a "News & Views" style article in the journal "Disease Models and Mechanisms". Offered spring semester.
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3.00 Credits
Poethig. Prerequisite(s): A college-level introductory course in genetics / molecular biology. The genetics of different organisms (mouse, Drosophila, C.elegans, Arabidopsis, etc.) will be considered with the various techniques employed to study the action of genes in these organisms.
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3.00 Credits
Section 401: Wells, Kahn. Section 402: Atchison. TiMM is planned as a once-weekly seminar course whose goal is to introduce students to the ways in which biomedical research can provide new insights into clinical medicine and, conversely, how knowledge of clinical disease impacts scientific discovery. There are two sections for the course -- 401 and 402. Section 401 is for first year MD/PhD students only and section 402 is for VMD/PhD and PhD students.
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3.00 Credits
D. Weissman, R. Collman, L. Montaner. Prerequisite(s): Strong background in cell biology, immunology or virology fulfilled by: 1st yr CAMB (previous BGS courses); CD -Module 1 of med school curriculum; very strong UG background. Instructor permission required for non-CAMB graduate students. This course will introduce students to diverse basic principles that contribute to viral pathogenesis. We will use HIV as a model to illustrate specific elements that relate to disease development, emphasizing a) pathogenesis, b) immunology, c) retroviral replication cycle, and d) vaccine develpment. Offered spring semester. One two-hour class weekly for the course of the semester. The first class will include two 45-minute introductory lectures given by the course instructors. Each week, a student will lead the class in the dissection and d iscussion of published papers on a specific topic. The format that we will follow will be a 20-minute introduction presented by the student followed by the analysis of one to two articles, which will be presented by the student and discussed by the class.
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3.00 Credits
F. Bushman. Prerequisite(s): Prior coursework in genetics and biochemistry. First priority to MVP students, then CAMB students, then GCB students. The course provides a detailed introduction to animal virology aimed at graduate students in the biomedical sciences.
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3.00 Credits
Zhu, J;. Prerequisite(s): Intro to Microbiology/Bacteriology. Priority given to graduate students. The format of this course will be two lectures and one student presentation/paper discussion per section. The course will begin by introducing approaches to the analysis of host-pathogen interaction. It will cover the general concepts and recent advance of how bacterial pathogens prepare to infect the host, the successful strategies bacteria used to infect the host, and how they survive after the infection.
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3.00 Credits
Farrell, J;. Permission needed from course director for non-CAMB students. Parasites infect over one quarter of the world's population and parasitic diseases are a leading cause of death globally. "Parasites and Parasitism" is to be offered to first and second year MVP students over a seven-week block in the spring semester. The course will begin with an introduction to the major protozoan and helminth pathogens of humans, their geographic distribution and the diseases they cause. Subsequent lectures will emphasize a variety of topics from the current research literature using specific parasitic pathogens as examples. These will include how various protozoans enter cells and adapt to different intracellular habitats or how helminths utilize different strategies to survive within the GI tract. Malaria and schistosomiasis will serve as examples for how parasites cause disease while trypanosomes and leishmaniasis will be discussed as models for how parasites survive or evade immune elimination. Finally, several helminth and protozoan systems will be used to demonstrate the intimate association between parasite and vector that leads to efficient transmission. In addition to lectures, weekly discussion sessions will provide an opportunity for students to review papers or research specific topics and present their findings to their colleagues.
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3.00 Credits
Sundaram, M. Course open to BGS students only, priority given to CAMB and GCB students. Students outside of CAMB or GCB require permission from course director to register. This is a required course of the Genetics and Gene Regulation Program and is designed to provide students with a comprehensive overview of genetic concepts and methodology. The course is organized into three parts: I Fundamental genetic concepts; II Genetics of model organisms (with a focus on yeast, worms flies and mice); III Human genetics and disease. Each week there will be two lectures and one associated discussion/problem-solving session. Discussions emphasize practical aspects of generating and interpreting genetic data. Offered spring semester.
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3.00 Credits
Abel/Bucan. Prerequisite(s): Permission of Instructor. This course focuses on the use of genetic techniques to study the molecular and cellular bases of behavior. Particular emphasis will be given to the role of genetic approaches in understanding the biological processes underlying memory storage, circadian rhythms, and neurological and psychiatric disorders. Reverse genetic approaches utilizing gene knockout and transgenic technologies, as well as forward genetic approaches using mutagenesis and quantitative genetic techniques will be discussed.
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3.00 Credits
Michael Granato, Jon Raper. Prerequisite(s): Background in introductory biology (molecular and cellular biology recommended.). The developmental neuroscience course opens with a brief summary of classical experimental embryology and key developmental concepts. Topics covered in the course include: vertebrate and invertebrate pattern formation; neural cell determination; growth cone guidance; synapse formation and plasticity; programmed cell death; neural growth factors; special sense organ development. Each week includes two lectures and a small group discussion in which one or two important papers are analyzed in detail. Each student must write three short grant-style reports (approximately 2 pages each). No exams are given.
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