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Course Criteria
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3.00 Credits
Wagner. Prerequisite(s): BIOL 221. This course will investigate epigenetic phenomena: heritable alternative states of gene activity that do not result from altered nucleotide sequence. Recent findings suggest an important role of these phenomena in normal development, as well as in oncogenesis. Many, but not all, epigenetic phenomena are based on the fact that in the organism DNA is organized into a higher order structure, the chromatin. We will therefore first discuss the implications of chromatin for gene activity. We will then investigate epigenetic phenomena such as DNA methylation, genomic imprinting, RNA interference, silencing, and co-suppression. This course is a combination of lecture and discussion using current scientific literature.
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3.00 Credits
Lampson, M. Prerequisite(s): The course is designed for advanced biology students who have taken BIOL 202 or equivalent. It is also open to graduate students. Life depends on the propagation of genetic material from one generation to next through cycles of genome replication and cell division. The genome is copied by the parent, and one exact copy is inherited by each daughter cell. We will treat chromosomes as discrete entities, rather than collections of genes, that are replicated and divided with high fidelity to ensure that the genome remains stable over many generations. By reading selected primary literature covering several decades, we will build an understanding of the cell cycle by focusing on chromosomes and the associated molecular machinery. We will explore mechanisms that underlie replication and division, particularly control mechanism that maintain genome integrity and are critical to prevent disease. The goal of the course is to develop a picture of the cell cycle by examining some of the key experiments and insights that have led to our current understanding. There is no textbook for the course. Readings from the primary literature will be assigned for each meeting and provided as pdf files. Presentations of these papers and class participation, including questions and critical evaluation, are an essential part of the course. Grading will be based on one in-class exam during the semester (30%), a final paper (30%), and class participation (40%, including paper presentations).
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3.00 Credits
Y. Chen, G. Silvestri, J. Wherry. Prerequisite(s): BIOM 600 or instructor permit. Priority given to students in the MVP & GTV programs of CAMB. CAMB students only. The purpose of this course is to give a thorough grounding in Immunology to Cell and Molecular Biology graduate students with an emphasis on the role of the immune system in combating infectious and neoplastic disease and its role in immunopathological states such as transplantation rejection, autoimmunity and allergy. This will be a required course for CAMB students in the Microbiology, Virology and Parasitology program and the Vaccine and Gene Therapy program, replacing Immune Mechanisms 506. It may also be used as an elective by other CAMB students such as Cancer Biology and Cell Biology and Physiology. The course is divided, by topic, into three parts. The first deals with innate and adaptive immune mechanisms, the structure, function, and molecular biology of antigen receptors and major histocompatibility complex molecules; the development and differentiation of lymphocytes and other hematopoietic cells involved in immunity and mechanisms of lymphocyte circulation and memory. The second part will cover the immune response in infection by bacteria, viruses and parasites and how this impacts on vaccine design and active immunization strategies. The course concludes by focusing on the immune system's role in pathological states such as cancer, allergy, graft rejection and autoimmunity. The formal part of the course is comprised of two 1.5 hour lectures per week. In addition each week there will be an informal 1.5-hour meeting, on Fridays, which will be used to introduce the students to specialized techniques used to measure immune responses or to discuss topical issues relating to the application of immunological knowledge in fighting disease with emphasis on the primary literature in the field. There will be two exams. The first will be taken after part I and the second after part II and III of the course.
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3.00 Credits
M. Mullins D. Kessler. Prerequisite(s): Previous courses in molecular and cellular biology are recommended. Undergrad background in cell biology and molecular biology required. NON-BGS students require permission from course directors to register. This graduate course, which will include lectures and readings from the literature, is designed to provide a foundation in the principles of developmental biology. Topics covered will include: fertilization and cleavage, pattern formation, gastrulation, germ layer formation, tissue specification, morphogenesis, tissue differentiation, organogenesis, stem cell biology, and developmental evolution. The use of modern molecular biology, genetics, and embryological manipulations will be discussed in the context of the analysis of developmental mechanisms.
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3.00 Credits
John Lynch, Kate Nathanson. Prerequisite(s): BIOM600 or course director permission. Non-CAMB students must contact the course director prior to registration. Students are permitted to audit this class for non-credit with the permission of the course director. The course objective is to introduce the students to important and current concepts in Cancer Biology and Cancer Genetics. The lectures are organized into 4 broad thematic groups: A) Cell-Autonomous Mechanisms (e.g., tumor suppressor and oncogene function, DNA repair pathways, senescence, apoptosis); B) Non Cell-Autonomous Mechanisms (e.g., tumor microenvironment, hypoxia, angiogenesis); C) Organ Systems (e.g., pancreatic cancer, hematopoetic malignancies); and D) Therapeutic Approaches (e.g. protein kinase inhibitors, immunotherapy, radiation therapy). The organizers, along with faculty from the School of Medicine, the Wistar Institute and CHOP, with expertise in the corresponding areas provide lectures for the course. The students are expected to present, and participate in discussions of one or more key recent papers at Journal Clubs that are held at the end of each thematic group. There will be mid-term and final exams of short essays relevant to the lectures.
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3.00 Credits
Dr. Carlo Maley and Dr. Lauren Merlo. Prerequisite(s): Permission of the instructor.Preference is given to students who have completed CAMB 512 and medical students. Cancers evolve by mutation and natural selection. This is the basis for both why we get cancer and why it so hard to cure. We will survey the cancer literature through the lens of evolutionary and ecological theory and review how that theory does and does not apply to cancer biology. This seminar is restricted to graduate students. This course is a graduate seminar course with both student and faculty presentations and discussions.
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3.00 Credits
Deutsch, C. Prerequisite(s): Basic knowledge of ion channels,Cell 600 or equivalent. The course is a seminar format, specifically a journal club format, targeted to graduate students and MD/PhD students interested in ion channels. It meets for one hour, once a week for graduate students and once every other week for the entire group with formal presentation. On alternate weeks a faculty member meets with students to discuss and review the contents of each selected article for the subsequent week's presentation. This is an elective course meant to excite and intellectually enlighten students regarding the latest advances in ion channel research. It includes a wide range of ion channel topics from basic biophysics, structure, and physiology to cell biology and clinical applications. It is attended by faculty, students, and postdocs from the departments of Physiology, Pathology, Neuroscience, Pharmacology, Biochemistry & Biophysics, Psychiatry. We require a written critique of each paper presented by other participants during the semester, submitted prior to the formal presentation of the paper. This critique will be graded by a faculty member, as will the student's participation in both the preparatory sessions and formal presentation sessions. In addition, the student will make one formal presentation, also graded by a faculty member. A final grade would be based on all three of these components.
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3.00 Credits
Cashmore. Prerequisite(s): Permission of instructor. The course aims to introduce principles of current experimental techniques used in modern biology.
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3.00 Credits
Diehl, Alan; McMahon, S; Assoian, R. Prerequisite(s): Prerequisite of CAMB 512 and/or BIOM 600 or equivalent graduate level advanced cell biology course. Anyone without BIOM600 or equivalent must obtain instructor permission. This seminar course will focus on molecular and biochemical events that regulate cell cycle transitions and their relevance to human cancer. Topics will include control of the G1/S, G2/M transitions and S-phase initiation/progression. Participants will gain an understanding of the specific roles played by cyclins, cdks, and their inhibitors. The regulation of the cell cycle by tumor suppressor genes such as p16, Rb and p53, and by oncogenes such as cyclin D, cdc25A, MDM2, and c-myc, will also be explored. Where appropriate, the focus will be on understanding regulation of cell cycle control through transcriptional control of gene expression, protein-protein interactions, posttranslational modifications, (eg. phosphorylation), or regulation of protein stability, (eg. via ubiquitin-targeted degradation). Although achieving an improved understanding of mammalian cancer is a goal of the course, much of our knowledge of the cell cycle derives from work done in more genetically tractable organisms such as yeast, drosophila, and xenopus. Therefore a great deal of emphasis will be placed on studies performed in these model systems.
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3.00 Credits
Kevin Foskett. Prerequisite(s): Although not a formal prerequisite, a good foundation in cell biology at the level of BIOM/CAMB 600 (or an equivalent upper level undergraduate course) is strongly recommended. A general understanding of the chemistry and biochemistry of macromolecules, and of basic molecular biology will also be assumed. This course is not open to undergraduate students. This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue, organ, and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal and gastrointestinal systems, and selected topics from the endocrine system. As well as providing a basis of integrative physiology for students in fields such as bioengineering and pharmacology,it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization.
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