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  • BIOL 475: Advanced Microbiology

    3.00 Credits
    University of Pennsylvania

    Pohlschroder/Daldal. Prerequisite(s): BIOL 221, BIOL 275, or permission of instructor. Microbiology plays a central role in diverse areas of human life such as infectious disease, ecology, and biotechnology. Following an overview of basic microbiological principles, the course will focus on in-depth discussions of selective cutting edge topics, including emerging technologies in microbiology. In addition to lectures given by experts in the field, students will present scientific papers on selected topics.
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  • BIOL 476: Microbiology Lab

    3.00 Credits
    University of Pennsylvania

    Pohlschroder/Daldal/Bassiri. Prerequisite(s): BIOL 275 or 475 recommended previously or concurrently. Lab fee $150. (3 hours lab, 0.5 cu). This course will provide practical, indepth laboratory experience with isolation, characterization, genetic and molecular biology of microorganisms.
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  • BIOL 480: Advanced Cell Biology

    3.00 Credits
    University of Pennsylvania

    Guo. Prerequisite(s): BIOL 202. This course is designed for beginning graduate students and advanced undergraduates with a particular enthusiasm for Cell Biology. Biology 480 does not attempt to cover all aspects of cell biology, and is therefore not appropriate for students seeking a lecture course which provides a comprehensive survey of the field. Rather, the primary objective of this course is to teach those students considering a career in the biomedical sciences how to read, discuss, and question original research papers effectively. Intensive classroom discussions focus on the experimental methods used, results obtained, interpretation of these results in the context of cell structure and function, and implications for further studies.
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  • BIOL 482: Communication at the Cellular Level

    3.00 Credits
    University of Pennsylvania

    Gallagher. Prerequisite(s): BIOL 202 or permission of instructor. The evolution of multicellularity required that cells be able to both send and receive signals from their neighbors. The development of organs and differentiation of cells and tissues requires reliable and continuous communication between cells. Consequences of inappropriate or anomalous signaling include development abnormalities and cancer. This class will examine mechanisms of cell-to-cell signaling between bacterial, plant, and animal cells with an emphasis on the cell biology of development. Particular attention will be given to the mechanims by which biomolecules are able to traffic from cell to cell and cross membranes and the role of the cytoskeleton in signaling.
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  • BIOL 483: Epigenetics

    3.00 Credits
    University of Pennsylvania

    Wagner D. Prerequisite(s): BIOL 221. This course investigates epigenetic phenomena: heritable alternate states of gene activity that do not result from an alteration in nucleotide composition (mutations). Epigenetic mechanisms regulate genome accessibility and cell differentiation. They play a key role in normal development and in oncogenesis. For example both mammalian X-chromosome inactivation and nuclear transfer (cloning) are subject to epigenetic regulation. Amongst the epigenetic mechanisms we will discuss in this course are chromatin organization, histone modification, DNA methylation and non-coding RNAs. The course is geared toward advanced undergraduate and beginning graduate students and is a combination of lectures, student presentations and research presentations by guest speakers. Students will work with the current scientific literature.
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  • BIOL 484: Cell Motility and the Cytoskeleton

    3.00 Credits
    University of Pennsylvania

    Svitkina. Prerequisite(s): BIOL 202. Cytoskeleton and cell motility plays a crucial role in many aspects of normal and pathological physiology of individual cells, tissues, and whole organisms, including morphogenesis, immune response, wound healing, oncogenesis, and infection. This course will cover current topics in cell biology with emphasis on cytoskeleton and cell motility and their roles in these processes. Lectures, student presentations, and discussions in the class will be based on primary scientific literature.
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  • BIOL 486: Chromosomes and the Cell Cycle

    3.00 Credits
    University of Pennsylvania

    Lampson. Prerequisite(s): BIOL 202 or permission of instructor. Life depends on the propagation of genetic material from one generation to the next through cycles of genome replication and cell division. The genome is copied by the parent, and one exact copy is inherited by each daughter cell. We will treat chromosomes as discrete entities, rather than collections of genes, that are replicated and divided with high fidelity to ensure that the genome remains stable over many generations. By reading selected primary literature covering several decades, we will build an understanding of the cell cycle by focusing on chromosomes and the associated molecular machinery. We will explore mechanisms that underlie replication and division, particularly control mechanisms that maintain genome integrity and are critical to prevent disease. The goal of the course is to develop a picture of the cell cycle by examining some of the key experiments and insights that have led to our current understanding.
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  • BIOL 488: Advanced Topics in Behavioral Genetics

    3.00 Credits
    University of Pennsylvania

    Abel/Bucan. Prerequisite(s): Permission of Instructor. This course focuses on the use of genetic techniques to study the molecular and cellular bases of behavior. Particular emphasis will be given to the role of genetic approaches in understanding the biological processes underlying memory storage, circadian rhythms, and neurological and psychiatric disorders. Reverse genetic approaches utilizing gene knockout and transgenic technologies, as well as forward genetic approaches using mutagenesis and quantitative genetic techniques will be discussed.
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  • BIOL 499: Advanced Independent Study

    3.00 Credits
    University of Pennsylvania

    Staff. Prerequisite(s): BIOL 399 in the same laboratory as the proposed BIOL 499. A second semester of independent study, in most cases extending the research undertaken for the Biol 399. Apply at the Biology Academic Office, 102 Leidy Labs.
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  • BIOL 501: Principles of Biological Science

    3.00 Credits
    University of Pennsylvania

    Waldron/Bergey. This course will provide a strong background in biology for middle school teachers in the MISEP program. The major topics will be animal and plant biology, cell biology and genetics, and evolution and diversity.
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