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Course Criteria
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3.00 Credits
Norman. The first half of the course treats Behavioral Genetics (e.g., genetic and envionmental components of IQ, personality, and psychopathology, gene-envioroment interaction), and the second half deals with Evolutionary Psychology (e.g., evolution of altruistic, cooperative, and competitive behavior). There are no prerequisites, but previous courses in Psychology, Biological Basis of Behavior, Anthropology, Biology, or Statistics would be helpful preparation. For additonal information see http://www.psych.upenn.edu/~normal/441Overview.htm
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3.00 Credits
Price. Prerequisite(s): Basic statistics or permission of instructor. This course covers basic principles of human and animal behavioral genetics, including normal variation and extreme phenotypes represented by behavioral, psychiatric and neurologic disorders. The course will focus on methods necessary to critically evaluate research findings on normal and abnormal human behavior. Animal models will also be reviewed. The first third of the class is in lecture format and reviews basic genetic methodologies as they apply to behavior. The remainder of the class is in seminar format and covers recently published work related to behavioral genetics.
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3.00 Credits
Lexow. This course will familiarize students with advances in our understanding of the clinical features and pathogenesis of a wide range of neurodegenerative diseases, including Alzheimer's disease and other dementias, prion diseases, Parkins's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron andcopper disorders, and mitochondrial diseases. Students will analyze original research reports on a range of proposed pathological cellular processes that may represent steps in cell death pathways leading to neuron loss seen in these diseases. Significant emphasis will be placed on the fast-expanding field exploring genetic contributions to neurodegenerative disease, as indentification of genetic mutations pathogenic for familial neurodegenerative diseases has been a major driving force in eurodegenerative research and pointed researchers towards essential molecular process that may underlie these disorders. Strategies for therapeutic intervention in the management, prevention, and cure of neurodegenerative disease will be addressed.
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3.00 Credits
Heerding. Prerequisite(s): BIBB 109 or Permission of Instructor. This seminar course reviews the behavioral effects of drugs in animals, the general biological and psychological principles of drug action, and the relationship between drugs that affect brain monoamine and opiate systems and their behavioral effects. Introductory lectures on general topics will be followed by advanced discussion of specific topics in a journal club format through student presentations.
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3.00 Credits
Prerequisite(s): BIBB 109 or 269 or 380, or permission of instructor. This course examines the history, rationale and putative mechanism of action of drugs used in the treatment of psychiatric disorders. Emphasis is placed on neurobiological processes underlying psychopathology and pharmacological intervention. Drugs currently in use as well as new drugs in development will be covered. Strategies, techniques, issues and challenges of clinical psychopharmacological research will be addressed and new approaches to drug discovery, including the use of pharmacogenomics and proteomics to understand variability in drug response and identify new molecular drug targets, will be covered in depth. Specific drug classes to be considered include antidepressants, anxiolytics, typical and atypical antipsychotics, narcotic analgesics, sedative hypnotics, and antiepileptic medications. A contrasting theme throughout the course will be the use of drugs as probes to identify neural substrates of behavior.
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3.00 Credits
Kaplan. Prerequisite(s): BIBB 109 and BIBB 251. Lab fee $100. In this lab course, a small number of students (12-20) meet once per week to discuss topics in synaptic physiology and to become proficient at sharp electrode techniques for intracellular recording, using isolated ganglia from the snail Heliosoma. The first part of each class will consist of discussion of weekly reading from the primary literature, with the remainder of the class devoted to hands-on experiments. After learning to record from and characterize single neurons, students will study synaptic transmission by stimulating incoming nerve trunks or by recording from pairs of interconnected neurons. As a midterm assignment, students will prepare and present a short research proposal using this model system, to be evaluated by the class. For the last half of the course, the class will work together on one or two of these proposals, meeting at the end of each class to pool our data, analyze the results and discuss their significance.
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3.00 Credits
Standing Faculty. Prerequisite(s): BIBB 399, permission of BIBB Director and a GPA of 3.3 or better. Corequisite(s): BIBB 400. Continuation of BIBB 399 research. Students will be required to present their oral defense and a poster at the annual BBB Symposium.
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3.00 Credits
Living World Sector. All classes. Staff. Prerequisite(s): High school biology required. May not be counted toward the Biology Major. Only offered through the College of Liberal and Professional Studies. This seminar is intended for students who do not plan to take any additional biology courses, but would like to know what "all the excitement" of modern biology is about. We will cover both the basics of molecular biology and how biotechnology effects our lives. Specific topics will include: DNA fingerprinting, environmental and health applications of genetic engineering and the human genome project.
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3.00 Credits
Living World Sector. All classes. Brisson. Microbes are a fundamental part of life on this planet. This course will explore the causes and consequences of the distribution and abundance of microbes (micrbial ecology) as well as microbial evolution on human health and disease risk. We will address the interplay between human society and microbial ecology and evolution in shaping disease risk and directing scientific study. This course will apply concepts from basic biology, ecology, and evolution to study infectious microbes as living creatures.
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3.00 Credits
May be counted as a General Requirement Course in Living World. Class of 2009 & prior only. Pohlschroder/Lafferty-DellaValle. Prerequisite(s): N-40 (Principles of General and Organic Chemistry) or CHEM 101 and 102 or the equivalent courses from an accredited college or university. Lab fee $150. (1.5 c.u.; 7 hours). This lecture and laboratory course introduces students to cellular biochemistry, molecular genetics, and microbiology to provide an understanding of the fundamental processes of living organisms, particularly as observed in bacteria and humans. Topics will include the organization and characteristics of prokaryotic and eukaryotic cells, the structural and functional relationships of the major biomolecules, interrelationships of the various metabolic pathways, and the basics of molecular biology and immunology.
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