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Course Criteria
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2.00 Credits
This course is a continuation of the course Fundamental Techniques of Imaging 1 (BE546). It builds upon the fall course instruction and continues to expose students to the fundamentals of modern techniques in biological and in vivo biomedical imaging. This course consists of a series of hands-on lab exercises, covering major imaging modalities, but also extends to non-radiology modalities of interest in biological, pathological or animal imaging (e.g., optical imaging). Topics include SPECT, Micro-CT, diffuse optical spectroscopy, in vivo fluorescence imaging, and computed tomography. The course will continue to emphasize the hands-on aspects of all areas of imaging and imaging analysis. Small groups of students will be led by a faculty member with technical assistance as appropriate.
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3.00 Credits
Prerequisite(s): BE 350 or equivalent, or permission of the instructor. Development of concepts about the operation of themammalian cardiovascular system as conceived in the years 198 (by Galenus), 1628 (by Harvey), and 1998 (at Penn by A. Noordergraaf).
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3.00 Credits
Prerequisite(s): Math through 241; BE 350, BE 324 as pre- or corequisites. Molecular & cellular biology. The goal of this course is to introduce students quantitative concepts in understanding and manipulating the behavior of biological cells. We will try to understand the interplay between molecules in cells and cell function. A particular focus is on receptors - cell surface molecules that mediate cell responses. We will also try to understand processes such as adhesion, motility, cytoskeleton, signal transduction, differentiation, and gene regulation.
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3.00 Credits
Prerequisite(s): Graduate Standing or instructor's permission. Tissue engineering demonstrates enormous potential for improving human health. While there is an extensive body of literature discussing the state of the art of tissue engineering, the majority of this literature is descriptive and does little to address the principles that govern the success or failure of an engineering tissue. This course explores principles of tissue engineering, drawing upon diverse fields such as developmental biology, immunology, cell biology, physiology, transport phenomena, material science, and polymer chemistry. Current and developing methods of tissue engineering as well as specific applications will be discussed in the context of these principles.
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3.00 Credits
Advanced study of re DNA techniques; bioreactor design for bacteria, mammalian and insect culture; separation methods; chromatography; drug and cell delivery systems; gene therapy; and diagnostics.
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3.00 Credits
Prerequisite(s): Background in Biology, Chemistry or Engineering with coursework in thermodynamics or permission of the instructor. From single molecule studies to single cell manipulations, the broad field of cell and molecular biology is becoming increasingly quantitative and increasingly a matter of systems simplification and analysis. The elaboration of various stresses on cellular structures, influences of interaction pathways and convolutions of incessant thermal motions will be discussed via lectures and laboratory demonstration. Topics will range from, but are not limited to, protein folding/forced unfolding to biomolecule associations, cell and membrane mechanics, and cell motility, drawing from very recent examples in the literature. Frequent hands-on exposure to modern methods in the field will be a significant element of the course in the laboratory. Skills in analytical and professional presentations, papers and laboratory work will be developed.
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3.00 Credits
This course will explore the biological effects of mechanical forces at the molecular, cellular and tissue level in specific tissues (blood vessels, cartilage, bone, brain, lung, and skeletal and cardiac muscle). The importance of physical forces in the health, disease, development, remodeling and injury of these tissues will be highlighted. An understanding of these specific systems will provide a foundation for discussions of the molecular basis of mechanotransduction, mechanically induced trauma, as well as the manipulation of the mechanical environment in biotechnology and tissue engineering applications. Throughout the course, the use of engineering principles and methods to understand and model mechanically induced biological phenomena will be stressed.
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3.00 Credits
Faculty. Prerequisite(s): Math through 241; BE350, BE324 as pre- or corequisites; Molecular & cellular biology. The goal of this course is to introduce students to quantitative concepts in understanding and manipulating the behavior of biological cells. We will try to understand the interplay between molecules in cells and cell function. A particular focus is on receptors - cell surface molecules that mediate cell responses. We will also try to understand processes such as adhesion, motility, cytoskeleton, signal transduction, differentiation, and gene regulation.
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3.00 Credits
Prerequisite(s): Undergraduates who have taken BE 324 or equivalent courses in Quantum Mechanics and/or Statistical Physics need no permission. Others, email instructor for permission. This course aims to provide theoretical, conceptual, and hands-on modeling experience on three different length and time scales that are crucial to biochemical phenomena in cells and to nanotechnology applications. Special Emphasis will be on cellular signal transduction. 60% lectures, 40% computational laboratory. No programming skills required.
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3.00 Credits
Drug Discovery & Development
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