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Course Criteria
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3.00 Credits
Skip Brass, MD, PhD; Gary Koretzky, MD, PhD; Mark Kahn, MD. Prerequisite(s): Permission of the course directors. The course is designed primarily for combined degree (MD/PhD) students, but will be available to all medical and graduate students as space permits. Prioritywill be given to 2st and 2nd year combined degree students. The optimal class size will be 14. Tentatively, the course will meet for one hour from 4 - 5 pm on Wednesday afternoons with occasional double sessions that will be two hours long. TiMM is planned as a once-weekly seminar course whose goal is to introduct students to the ways in which biomedical research can provide new insights into clinical medicine and, conversely, how knowledge of clinical disease impacts scientific discovery.
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3.00 Credits
Lucki and staff. Prerequisite(s): Permission of instructor. Meets two times per week. Biological issues relevant to neuropsychiatric illnesses are covered in detail in four sections. The first section covers clinical aspects of major psychiatric disorders and includes some contact with patients. The second section presents the neuroanatomy of the limbic system. In the third section, emphasis is on the mechanisms of action of psychotropic drugs, including antidepressants, antipsychotics, anxiolytics, and stimulants. The final section covers information relevant to understanding biological processes that may be abnormal in neuropsychiatric illnesses, such as stress, sleep, and circadian rhythms, as well as quantitative genetics.
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3.00 Credits
Drs. Vladimir Muzykantov and Emer Smyth. Prerequisite(s): Permission of course director. Lectures to be presented by various Medical School faculty members. Topics covered include: general principles of vascular biology and hemodynamics, endothelial cells and integral vascular functions, signaling in the cardiovascular system, angiogenesis, hemostasis and thrombosis, platelets, platelet/vascular interactions, vascular integrins and adhesion molecules, vascular inflammation and oxidative stress, white blood cells, vasoactive compounds and drugs, mechanisms of atherosclerosis, cholesterol and lipid metabolism, hypertension, novel vascular directed gene and enzyme therapies.
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3.00 Credits
DR. A. STEVEN WHITEHEAD. Prerequisite(s): Permission of course director. This is a "literature-based" course (i.e. a seminar course/literature survey). It will survey the emerging technologies and computational advances that have permitted the field of pharmacogenetics to mature into a major biomedical discipline over the past few years. It will consider the likely impact on disease target identification,the development of new drugs for established and "niche" markets, the advent of "personalized medicine", including the selection of therapies that have maximum efficacy and minimum side-effect profiles. This course will also touch on some of the ethic issues associated with the routine genetic testing of patients to facilitate treatment choices and clinical monitoring.
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3.00 Credits
Dr. Trevor M. Penning. Prerequisite(s): Pre-requisites: Must have taken or will take Fundamentals of Pharmacology concurrently. Undergraduate course work in biochemistry and chemistry essential. Exceptions allowed based on past course work. Please consult with Course Director. Students: All 1st and 2nd year GGPS, CAMB, Neuro and BSTA students with required prerequisites; residents in Environmental and Occupational Health, and professional masters students (MPH and MTR). Course Goals: Exposures to foreign compounds (drugs, carcinogens, and pollutants) can disrupt normal cellular processes leading to toxicity. This course will focus on the molecular mechanisms by which environmental exposures lead to end-organ injury and to diseases of environmental etiology (neurodegenerative and lung diseases, reproduction disruption and cardiovascular injury). Students will learn the difficulties in modeling response to low-dose chronic exposures, how these exposures are influenced by metabolism and disposition, and how reactive intermediates alter the function of biomolecules. Mechanisms responsible for cellular damage, aberrant repair, and end-organ injury will be discussed. Students will learn about modern predictive molecular toxicology to classify toxicants, predict individual susceptibility and response to environmental triggers, and how to develop and validate biomarkers for diseases of environmental etiology. Students are expected to write a term paper on risk assessment on an environmental exposure using available TOXNET information.
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3.00 Credits
Axelsen and staff. Prerequisite(s): Permission of the instructor. Class meets four days a week. This course will review basic human physiology pertinent to drug action, and then focus on the mechanisms of action of the various classes of agents used in the therapy of human disease. It consists of lectures by an array of faculty with special interests and expertise in the topic being presented. Drug classes covered include: Neuropsychiatric drugs, cardiovascular and hematological drugs, anticancer drugs, antimicrobial drugs, endocrine and metabolic drugs.
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3.00 Credits
Dr. David Manning and staff. Prerequisite(s): Permission of course director. Meets three times per week. This course is designed to introduce students to basic pharmacological concepts with special emphasis on the molecular actions of drugs. Subject matter includes use of microcomputers to analyze pharmacological data.
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3.00 Credits
Dr. Ian Blair, Dr. Barry Cooperman, Dr. Dewey McCafferty. Prerequisite(s): Permission of the courses directors. This advanced course for graduate students will be based primarily on didactic lectures from three Penn faculty. Permission for a student to participate should first be obtained from one of the participating faculty. A solid background in chemistry and biochemistry will be required. Overviews of current and emerging topics in bioorganic and medicinal chemistry will be presented. Students will be given short "take home" problem sets, two formal interim examinations, and a formal final examination during the semester. Topics that will be covered over the semester include: Mass spectrometry of DNA and DNA-adducts, Synthetic peptides/peptide mimics/proteins, including the expansion of the genetic code; methods of synthesis and applications, Synthetic RNAs, DNAs and nucleic acid mimics: methods of synthesis and applications, Synthetic oligosaccharides: methods of sythesis and applications, Combinatorial chemistry, Enzymology of translation, Antibiotic biosynthesis, Introduction to drug metabolism, Characterization of drug metabolites, Characterization of reactive metabolites from drugs and endogenous molecules, DNA-adducts from drugs and endogenous molecules, Lipidomics in drug development.
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3.00 Credits
Boettiger. Prerequisite(s): BIOM600 or similar course in molecular cell biology. Limited to BGS, SAS, and Engineering graduate group students. Others by permit only. This is a seminar course in the molecular mechanisms underlying the organization, dynamics and signaling through cell adhesion and the cytoskeleton. The course will cover the basic principles and biology of the molecules involved in cell-cell and cell-matrix adhesion and their interface with the cytoskeleton. This is an advanced seminar course. Students will present papers that will be selected to highlight classical and emerging methods including genetic screens, pharmacological studies, physical approaches, and genomic approaches. The issues addressed include regulation of cell adhesion, control of cell motility, and roles of adhesion and adhesion signaling in cancer and cardiovascular disease. Students will also present one paper of their own choosing. All presentations will be prepared in consultation with a faculty member with expertise in the specific area. The course requires a minimum of seven registered students to be offered.
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3.00 Credits
Dr. Judy Meinkoth and Dr. Wenchao Song. Prerequisite(s): permission of course directors. Class meets Wednesdays, 1:00 - 3:00; Fall semester. Reviews of current literature on topics such as cancer cell signaling, cancer genetics, hormonal carcinogens, environmental carcinogens, chemo- and gene therapy of cancer, cancer epidemiology and prevention. New hypotheses in cancer etiology, prevention and treatment will be discussed as they appear in the literature. The aim of the course is to introduce the students to the latest development in the above areas related to cancer pharmacology.
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