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INSC 581: Auditory Neurobiology
3.00 Credits
University of Pennsylvania
James Saunders. The purpose of this course is to convey to upper level undergraduates and graduate students the fundamental processes and mechanisms of the auditory system. The course will develop ideas describing the structure and function of the peripheral and central auditory pathway. The flow of acoustic energy will be analytically and quantitatively traced through the peripheral ear. The details of auditory transduction will be explored as a mechanical and electrochemical system. Information transfer to simple and complex acoutic signals in the central auditory pathway will be explored from the auditory nerve to the cortex. In addition, the pathophysiology or hearing due to excessive sound exposure or ototoxic drug treatment will be considered. The database used in the course will come from primary literature describing the the physiological mechanisms of heaing in animal preparations. However, where appropriate, the processes of human hearing will be introduced.
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INSC 582: Behavioral Neuropharmacology. 583. SEMINAR FMRI DATA ANALYS
3.00 Credits
University of Pennsylvania
Seminar FMRI Data Analysis.
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INSC 582 - Behavioral Neuropharmacology. 583. SEMINAR FMRI DATA ANALYS
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INSC 584: Neurobiology of Sleep and Circadian Rhythms
3.00 Credits
University of Pennsylvania
Allan Pack. The objectives of this course are: to discuss and evaluate mechanisms controlling sleep and circadian rhythms; to survey novel approaches to investigations in these areas; indicate the clinical relevance of these ideas were possible. About half the course consists of core lectures on basic rhythms, sleep, and their neural substrates. The rest of the lectures are devoted to special topics which change from year to year.
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INSC 584 - Neurobiology of Sleep and Circadian Rhythms
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INSC 587: Neurobiology of Disease
3.00 Credits
University of Pennsylvania
Marc Dichter. Prerequisite(s): Working knowledge of biology and chemistry. Corequisite(s): Permission of course director. This course is designed to familiarize neuroscientists with basic information about a number of important neurological and psychiatric disease, focusing on a relatively brief clinical description of the condition and a more in depth discussion of what is currently understood about the basic pathobiology of the disorder. The course is divided into two parts: on Tuesday afternoons there will be a formal didactic teaching session. The first part of each lecture (1/2 hour to 1 hour) will be devoted to a discussion of the disease in question and the second part will consist of one or two student presentations (in lieu of a paper or exam) reviewing in depth one critical neuroscience component of the disease. Each student will work with the course director or an assigned faculty member to develop her/his lecture. On Thursday afternoons, a faculty member will present a research seminar or chalk talk describing the research she or he is conducting in that particular disease. Papers will be provided before the seminar so the students will be familiar with the research. It is expected that having a research seminar given after the introductory lecture will allow the students to become familiar in depth with at least one approach to each disease.
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INSC 587 - Neurobiology of Disease
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INSC 592: Cognitive Neuroscience of Memory
3.00 Credits
University of Pennsylvania
Sharon Thompson-Schill. Prerequisite(s): none. Corequisite(s): none. This course will review the neural mechanisms of learning and memory. Readingswill include both seminar and cutting-edge papers on topics ranging from perceptual memory to higher order functions, including working memory, declarative memory, skill learning, and semantic memory. Within each topic we will attempt to integrate the results of different neuroscience approaches, including the study of human neurological patients, lesion studies and single unit recordings in animals, neural network modeling, event-related potentials, and functional imaging techniques.
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INSC 593: Structural Neurobiology
3.00 Credits
University of Pennsylvania
Peter Sterling. This course presents brain structure on all levels from gross morphology to microcircuity to synaptic architecture. It is a lab course which emphasizes learning to find your way around the brain using maps at various levels of resolution. We emphasize learning to "read" the structures and learning the modern methods of studying functional neural architecture. This includes, methods for tracing pathways and identifying chemical architecture. Also, advanced methods of light microscopy will be covered including flourescence, video-DIC, confocal.
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INSC 593 - Structural Neurobiology
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INSC 594: Computational Neuroscience
3.00 Credits
University of Pennsylvania
Finkel. Prerequisite(s): Previous coursework in physiology and in differential equations and some familiarity with computers, or instructor's permission. Theoretical studies of neural function from the molecular to the cognitive level. Emphasis on organization and function of neural maps, synaptic plasticity, vision, and recent neural network models of higher brain functions and on neurobiological problems that are well suited to computational study.
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INSC 594 - Computational Neuroscience
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INSC 596: Neurochem-Neuropharm
3.00 Credits
University of Pennsylvania
Steve Thomas. Prerequisite(s): Permission of course director. The goals of this course are: a) to provide students with a general overview of the biochemical properties of the nervous system; b) to provide students with in-depth information on particular neurotransmitter and effector systems. Emphasis will be placed on the wealth of new molecular information that is being gathered to examine how cells of the nervous system function and communicate. To achieve these goals, the course is divided into 4 sections: 1) overview of neuroanatomy and general neurochemistry; 2) specific neurotransmitters and neuromodulators; 3) molecular approaches to the study of signalling in CNS; 4) current topics in neuropharmacology. There will be 3 exams that roughly correlate with the first 3 sections. The fourth section will entail student presentations toward the end of the semester.
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INSC 596 - Neurochem-Neuropharm
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INSC 597: Developmental Neurobiology
3.00 Credits
University of Pennsylvania
Jeff Golden. The developmental neuroscience course opens with a brief summary of classical experimental embryology and key developmental concepts. Topics covered in the course include: invertebrate and vertebrate pattern formation; neural cell determination; growth cone guidance; synapse formation and plasticity; programmed cell death; neural growth factors; special sense organ development. Each week includes two lectures and a small group discussion in which one or two important papers are analyzed in detail. Each student must write three short grant-style reports (approximately 2 pages each). No exams are given.
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INSC 598: Advanced Systems Neuroscience
3.00 Credits
University of Pennsylvania
Gary Aston-Jones. Prerequisite(s): Core III or Permission of course director. This course will evaluate neural function from a systems perspective, using 4 different brain systems as examples: noradrenergic, olfactory, sleep and vestibular. (i) G. Aston-Jones will describe the neuroanatomy, neurophysiology, neuropharmacology and behavioral properties of the locus coeruleus and A1/A2 noradrenergic brain systems. He will use these basic circuit properties to examine hypothesis for roles of these systems in addiction and cognitive function. (ii) M. Ma will focus on the cellular and molecular mechanisms underlying olfactory information coding and processing. This section will deal with one basic question, i.e., what enables us to detect and discriminate thousands of odors. (iii) M. Frank will review the behavioral and electrophysiological features of REM and nonREM sleep, as well as the underlying anatomical structures and neurotransmitter/neurohumeral systems that generate and modulate each state. Several theories of sleep function, including the possible role of sleep in neuronal metabolism, brain development and learning and memory will be reviewed. (iv)D. Solomon will detail the neural circuitry and physiological mechanisms involved in balance and other vestibular functions.
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INSC 598 - Advanced Systems Neuroscience
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